Molecular analysis of the cyclin-dependent kinase inhibitor genes p15(INK4b/MTS2), p16(INK4/MTS1), p18 and p19 in human cancer cell lines

International Journal of Cancer

Volumn 68, Issue 5, 1996, Pages 605-611

  Gemma, Akihiko ^a   Takenoshita, Seiichi ^a   Hagiwara, Koichi ^a   Okamoto, Aikou ^a   Spillare, Elisa A ^a   Mcmemamin, Mary G ^a   Perwez Hussain, S ^a   Forrester, Kathleen ^a   Zariwala, Maimoona ^b   Xiong, Yue ^b   Harris, Curtis C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4 INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P16; PROTEIN P19; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HUMAN; IMMUNOBLOTTING; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P19; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; TUMOR CELLS, CULTURED;

EID: 8044223425     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19961127)68:5<605::AID-IJC9>3.0.CO;2-2     Document Type: Article

References (22)

1. BANKS-SCHLEGEL, S.P. and QUINTERO, J., Growth and differentiation of human esophageal carcinoma cell lines. Cancer Res., 46, 250-258 (1986).
2. 1 checkpoint control. Cell, 82, 675-684 (1995).
3. EL-DEIRY, W.S., TOKINO, T., VELCULESCU, V.E., LEVY, D.B., PARSONS, R., TRENT, J.M., LIN, D., MERCER, W.E., KINZLER, K.W. and VOGEL-STEIN, B., WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825 (1993).
4. INK4/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Develop., 8, 2939-2952 (1994).
5. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature (Lond.), 371, 257-261 (1994).
6. INK4B1 Cancer Res., 56, 722-727 (1996).
7. HIRAI, H., ROUSSEL, M.F., KATO, J.-Y., ASHMUN, R.A. and SHERR, C.J., Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. cell. Biol., 15, 2672-2681 (1995).
8. CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Develop. 9, 650-662 (1995).
9. MERLO, A., HERMAN, J.G., MAO, L., LEE, D.J., GABRIELSON, E., BURGER, P.C., BAYLIN, S.B. and SIDRANSKY, D., 5′CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature (Med.), 1, 686-692 (1995).
10. NOBORI, T., MIURA, K., WU, D.J., LOIS, A., TAKABAYASHI, K. and CARSON, D.A., Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368, 753-756 (1994).
11. OHTA, M., NAGAI, H., SHIMIZU, M., RASIO, D., BERD, D., MASTRAN-GELO, M., SINGH, A.D., SHILDS, J.A., SHILDS, C.L., CROCE, C.M. and HUEBNER, K., Rarity of somatic germline mutation of the cyclin-dependent kinase 4 inhibitor gene, CDK41, in melanoma. Cancer Res., 54, 5269-5272 (1994).
12. 1NK4 in human cancer. Proc. nat. Acad. Sci. (Wash.), 91, 11045-11049 (1994).
13. INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res., 55, 1448-1451 (1995).
14. KIP1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res., 55, 1211-1214 (1995).
15. SERRANO, M., HANNON, G.J. and BEACH, D., A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366, 704-707 (1993).
16. SERRANO, M., LEE, H.-W., CHIN, L., CORDON-CARDO, C., BEACH, D. and DEPINHO, R.A., Role of the INK4a locus in tumor suppression and cell mortality. Cell, 85, 27-37 (1996).
17. INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res., 55, 6200-6209 (1995).
18. SPILLARE, E.A., OKAMOTO, A., HAGIWARA, K., DEMETRICK, D.J., SERRANO, M., BEACH, D. and HARRIS, C.C., Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4. Mol. Carcinogenesis, 16, 53-60 (1996).
19. STONE, S., JIANG, P., DAYANANTH, P., TAVTIGIAN, S.V., KATCHER, D.P., PARRY, D., PETERS, G. and KAMB, A., Complex structure and regulation of p16(MTS1) locus. Cancer Res., 55, 2988-2994 (1995).
20. TAKEUCHI, S. and 12 OTHERS, Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. Blood, 86, 755-760 (1995).
21. 1 cyclin-cdk protein kinase activity, is related to p21. Cell, 78, 67-74 (1994).
22. XIONG, Y., ZHANG, H. and BEACH, D., D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell, 71, 505-514 (1992).