Mutant RBL mast cells defective in FcεRI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases

Molecular Biology of the Cell

Volumn 11, Issue 10, 2000, Pages 3661-3673

  Field, K A ^a   Apgar, J R ^a   Hong Geller, E ^a   Siraganian, R P ^a   Baird, B ^a   Holowka, D ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ARACHIDONIC ACID; CALCIUM ION; FC RECEPTOR; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN E RECEPTOR; PHOSPHOLIPASE A2; PHOSPHOLIPASE D; RHO FACTOR; T LYMPHOCYTE RECEPTOR; TRITIUM;

ARTICLE; BIOSYNTHESIS; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; MAST CELL DEGRANULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VACCINIA VIRUS;

EID: 0033782836     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.10.3661     Document Type: Article

References (58)

1. 2+ stores
2. 2+-ionophore-induced secretion in a rat mast cell line
3. The activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells: Evidence for a novel adenosine receptor
4. Polymerization of actin in RBL-2H3 cells can be triggered through either the IgE receptor or the adenosine receptor but different signaling pathways are used
5. Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Correlation with actin polymerization
6. 2, C, and D activity in RBL cells stimulated through FcεRI is due to spreading and not simply adhesion
7. Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by FcεRI cross-linking
8. Wortmannin-sensitive phosphorylation, translocation, and activation of PLCγ1, but not PLCγ2, in antigen-stimulated RBL-2H3 mast cells
9. IgE-induced histamine release from rat basophilic leukemia cell lines: Isolation of releasing and nonreleasing clones
10. Lithium amplifies agonist-dependent phosphatidyinolitol responses in brain and salivary glands
11. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase C activity
12. The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways
13. Phosphotyrosine-dependent activation of Rac-1 GDP/ GTP exchange by the Vav proto-oncogene product
14. Fc receptor biology
15. Ligand recognition by alpha-beta T cell receptors
16. Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi Apparatus
17. FcεRI-mediated recruitment of p53/56(lyn) to detergent-resistant membrane domains accompanies cellular signaling
18. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains
19. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
20. The role of actin microfilaments in the down-regulation of the degranulation response in RBL-2H3 mast cells
21. Phospholipase A2 stimulation during cell secretion in rat basophilic leukemia cells
22. An indirect pathway of receptor-mediated 1,2-diacylglycerol formation in mast cell. I. IgE receptor-mediated activation of phospholipase D
23. Monoclonal antibody AA4, which inhibits binding of IgE to high affinity receptors on rat basophilic leukemia cells, binds to novel α-galactosyl derivatives of ganglioside G(D1b)
24. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
25. Correctly sorted molecules of a GPI-anchored protein are clustered and immobile when they arrive at the apical surface of MDCK cells
26. Altered patterns of tyrosine phosphorylation and Syk activation for sterically restricted cyclic dimers of IgE-FcεRI
27. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets
28. 2 pathway by FcεRI is not shared by a G protein-coupled receptor
29. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
30. 3/calcium pathway in RBL-2H3 mast cells
31. 2 by the Rho GTPases Cdc42Hs and Rac1
32. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
33. The high affinity IgE receptor (FcεRI): From physiology to pathology
34. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells
35. Genetic analysis of B cell antigen receptor signaling
36. Activation of phospholipase D in a rat mast (RBL 2H3) cell line
37. Phosphatidylcholine-specific phospholipase D-derived 1,2-diacylglycerol does not initiate protein kinase C activation in the RBL-2H3 mast cell line
38. Small oligomers of immunoglobulin E (IgE) cause large-scale clustering of IgE receptors on the surface of rat basophilic leukemia cells
39. 2+ in individual stimulated tumor mast cells
40. T cell receptor-mediated signaling occurs in the absence of inositol phosphate production
41. CD19 as a membrane-anchored adaptor protein of B. lymphpocytes: Co-stimulation of lipid and protein kinases by recruitment of Vav
42. Binding of monoclonal antibody AA4 to gangliosides on rat basophilic leukemia cells produces changes similar to those seen with Fcε receptor activation
43. Membrane and cytoskeletal changes associated with IgE-mediated serotonin release from rat basophilic leukemia cells
44. Evidence supporting a role for microfilaments in regulating the coupling between poorly dissociable IgE-FcεRI aggregates and downstream signaling pathways
45. FcεRI-mediated association of 6-μm beads with RBL-2H3 mast cells results in exclusion of signaling proteins from the forming phagosome and abrogation of normal downstream signaling
46. Initiation and processing of signals from the B cell antigen receptor
47. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
48. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Igα/Igβ immunoreceptor tyrosine activation motif binding and autophsophorylation
49. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcεRI and their association with detergent-resistant membranes
50. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE
51. Functional rafts in cell membranes
52. Binding properties and histamine release in variants of rat basophilic leukemia cells with changes in the IgE receptor
53. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes
54. Evidence for a gelsolin-rich, labile F-actin pool in human polymorphonuclear leukocytes
55. Signal transduction by lymphocyte antigen receptors
56. Membrane compartmentation and the response to antigen
57. Kinetics of multivalent antigen DNP-BSA binding to IgE-Fcε?RI in relationship to the stimulated tyrosine phosphorylation of FcεRI
58. Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells