Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors

Journal of Molecular Medicine

Volumn 74, Issue 5, 1996, Pages 253-268

  Streit, M ^a   Schmidt, R ^a   Hilgenfeld, R U ^b   Thiel, E ^a   Kreuser, E D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b St Joseph Hospital Berlin   (Germany)

Author keywords

adhesion receptors; cadherins; CD44; gastrointestinal tumors; integrins

Indexed keywords

ADHESION MOLECULE RECEPTOR; CADHERIN; CELL ADHESION MOLECULE; HERMES ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LAMININ; MONOCLONAL ANTIBODY; TUMOR MARKER; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL TRANSFORMATION; DISSEMINATED CANCER; GASTROINTESTINAL TUMOR; GENE EXPRESSION; HUMAN; PROGNOSIS; REVIEW;

EID: 0029997916     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00196578     Document Type: Review

References (140)

1. Abbasi AM, Chester KA, Talbot IC, Macpherson AS, Boxer G, Forbes A, Malcom ADB, Begent RHJ (1993) CD44 is associated with proliferation in normal and neoplastic human colorectal epithelial cells. Eur J Cancer 29:1995-2002
2. Agrez MV, Bates RC (1994) Colorectal cancer and the integrin family of cell adhesion receptors: current status and future directions. Eur J Cancer 30:2166-2170
3. Albelda SM, Buck C (1990) Integrins and other cell adhesion molecules. FASEB 4:2868-2880
4. Aznavoorian S, Marphy AN, Stetler-Stevenson WG, Liotta LA (1993) Molecular aspects of tumor cell invasion and metastasis. Cancer 15:1368-1383
5. Aznavoorian S, Liotta LA, Kupchik HZ (1990) Characteristics of invasive and noninvasive human colorectal adenocarcinoma cells. J Natl Cancer Inst 82:1485-1492
6. Bates RC, Buret A, vanHelden D, Horton MA, Burns GF (1994) Apoptosis induced by inhibition of intercellular contact. J Cell Biol 125:403-415
7. Beck K, Hunter I, Engel J (1990) Structure and function of laminin: anatomy of a multidomain glycoprotein. FASEB 4:148-160
8. Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Höfler H (1994) E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 54:3845-3852
9. Becker KF, Atkinson MJ, Reich U, Huang HH, Nekarda H, Siewert JR, Höfler H (1993) Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Hum Mol Genet 2:803-804
10. Behrens J, Mareel MM, Van Roy FM, Birchmeier W (1989) Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin mediated cell-cell adhesion. J Cell Biol 108:7435-7447
11. Behrens J, Vakaet L, Winterhager E, Van Roy F, Mareel MM, Birchmeier W (1993) Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol 120:757-766
12. 1 chain Ile-Lys-Val-Ala-Val (IKVAV)-containing peptide promotes liver colonization of human colon cancer cells. Cancer Res 55:2476-2480
13. Birchmeier W, Weidner KM, Hülsken J, Behrens J (1993) Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas. Semin Cancer Biol 4:231-239
14. 3 for angiogenesis. Science 264:569-571
15. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79:1157-1164
16. Buxton RS, Cowin P, Franke WW, Garod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, Steinberg MS (1993) Nomenclature of the desmosomal and other cadherins. J Cell Biol 121:481-483
17. Carter WG, Wagner EA (1988) Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells. J Biol Chem 263:4193-4201
18. Castronovo V (1993) Laminin receptors and laminin-binding proteins during tumor invasion and metastasis. Invasion Metastasis 13:1-30
19. Castronovo V, Colin C, Claysmith AP, Chen PH, Lifrange E, Lambotte R, Kratzsch H, Liotta LA, Sobel ME (1990) Immunodetection of the metastasis associated laminin-recptor in human breast cancer cells obtained by fine-needle aspiration biopsy. Am J Pathol 137:1373-1381
20. Castronovo V, Tarboletti G, Sobel ME (1991) Functional domains of the 67 kD laminin receptor precursor. J Biol Chem 226:20440-20446
21. Castronovo V, Campo E, van den Brule FA, Claysmith AP, Cioce V, Liu FT, Fernandez PL, Sobel ME (1992) Inverse modulation of steady-state messenger RNA levels of two nonintegrin laminin-binding proteins in human colon carcinoma. J Natl Cancer Inst 84:1161-1169
22. Choy MY, Richman PI, Horton MA, MacDonald TT (1990) Expression of the VLA family of integrins in human intestine. Am J Pathol 160:35-40
23. Cioce V, Castronovo V, Shmookler BM, Garbisa S, Grigioni WF, Liotta LA, Sobel ME (1991) Increased expression of the laminin receptor in human colon cancer. J Natl Cancer Inst 83:29-36
24. Correa P, Shiao Y (1994) Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res 54:1941-1943
25. Daidone MG, Silvestrini R, D'Errico A, Di FG, Benini E, Mancini AM, Garbisa S, Liotta LA, Grigioni WF (1991) Laminin receptors, collagenase IC and prognosis in node negative breast cancers. Int J Cancer 48:529-532
26. Dämmrich J, Vollmers HP, Heider KH, Müller-Hemelink HK (1995) Importance of different CD44 v6 expression in human gastric intestinal and diffuse type cancers for metastatic lymphogenic spreading. J Mol Med 73:395-401
27. Daneker GW, Piazza AJ, Steele GD, Mercurio AM (1989) Relationship between extracellular matrix interactions and degree of differentiation in human colon carcinoma cell lines. Cancer Res 49:681-686
28. Demeter LM, Stoler MH, Sobel ME, Broker ME, Chow LT (1992) Expression of high affinity laminin receptor mRNA correlates with cell proliferation rather than invasion in human papilloma virus associated neoplasms. Cancer Res 52:1561-1567
29. D'Errico A, Garbisa S, Liotta LA, Castronovo V, Stetler-Stevenson SW (1991) Augmentation of type IV collagenase, laminin receptor, and Ki67 proliferation antigen associated with human colon, gastric, and breast carcinoma progression. Mod Pathol 4:239-246
30. Diamond MS, Springer TA (1994) The dynamic regulation of integrin adhesiveness. Curr Biol 4:506-517
31. Doki Y, Shiozaki H, Tahara H, Inoue M, Oka H, Iihara K, Kadowski T, Takeichi M, Mori T (1993) Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res 53:3421-3426
32. Dorudi S, Sheffield JP, Poulson R, Northover JMA, Hart IR (1993) E-cadherin expression on colorectal cancer: an immunocytochemical and in situ hybridization study. Am J Pathol 142:981-986
33. Dorudi S, Hanby AM, Poulson R, Northover J, Hart IR (1995) Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 71:614-615
34. East JA, Hart IR (1993) CD44 and its role in tumour progression and metastasis. Eur J Cancer 29:1921-1922
35. Edelman S, Damsky CH, Wheelock MJ, Damjanov I (1989) Expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in normal human tissues and tumors. Am J Pathol 135:101-110
36. Edward M (1995) Integrins and other adhesion molecules involved in melanocytic tumor progression. Curr Oncol 7:185-191
37. Fearon ER, Jones PA (1992) Progression toward a molecular description of colorectal cancer development. FASEB 6:2783-2790
38. Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79:185-188
39. Finn L, Dougherty G, Finley G, Meisler A, Becich M, Cooper DL (1994) Alternative splicing of CD44 pre-mRNA in human colorectal tumors. Biochem Biophys Res Comm 200:1015-1022
40. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Löchner D, Birchmeier W (1991) E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113:173-185
41. Gehlsen KR, Argraves WS, Pierschbacher MD, Ruoslahti (1988) Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides. J Cell Biol 106:925-930
42. Geiger B, Agalon O (1992) Cadherins. Ann Rev Cell Biol 8:307-332
43. Ginsberg MH, Xiaoping DU, Flow E (1992) Inside-out integrin signaling. Curr Opin Cell Biol 4:766-771
44. 1 chain mediates cell adhesion and binds the 671000 laminin receptor. Biochem 26:6896-6900
45. Günthert U, Hofmann M, Rudy W, Reber S, Zöller M, Haußmann I, Matzku S, Wenzel A, Ponta H, Herrlich P (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65:13-24
46. Günthert U, Stauder R, Maxer B, Terpe HJ, Fincke L, Friedrichs K (1996) Are CD44 variant isoforms involved in human tumour progression. (in preparation)
47. Guo YJ, Liu G, Wang X, Jin D, Wu M, Ma J, Sy MS (1994) Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer. Cancer Res 54:422-426
48. Hall PA, Coates PJ, Lemoine NR, Horton MA (1991) Characterisation of integrin chains in normal and neoplastic human pancreas. J Pathol 165:33-41
49. Harn HJ, Ho LI, Chang JY, Wu CW, Jiang SY, Lee HS, Lee WH (1995) Differential expression of the human metastasis adhesion molecule CD44v in normal and carcinomatous stomach mucosa of chinese subjects. Cancer 75:1065-1071
50. Heider KH, Dämmrich J, Skroch-Angel P, Müller-Hermelink HK, Vollmers HP, Herrlich P, Ponta H (1993) Differential expression of CD44 splice variants in intestinal- and diffuse-type human gastric carcinomas and normal gastric mucosa. Cancer Res 53:4197-4203
51. Heider KH, Hofmann M, Hors E, van den Berg F, Ponta H, Herrlich P, Pals ST (1993) A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J Cell Biol 120:227-233
52. Heino J (1993) Integrin-type extracellular matrix receptors in cancer and inflammation. Ann Med 25:335-342
53. Herrlich P, Zöller M, Pals ST, Ponta H (1993) CD44 splice variants: metastases meet lymphocytes. Immunol Today 14:395-399
54. Herzberg F, Schöning M, Schmidt R, Schirner M, Kaufmann C, Schön M, Thiel E, Kreuser E-D (1996) De novo expression of the fibronectin receptor α5β1 in HT29 carcinoma cells reduces cell growth and induces differentiation-related effects. Exp Cell Res (in press)
55. Horan-Hand P, Thor A, Schlom J, Rao CN, Liotta L (1985) Expression of laminin receptor in normal and carcinomatous tissues as defined by monoclonal antibody. Cancer Res 45:2713-2719
56. Humphries M, Yamada KM, Olden K (1988) Investigations of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells. J Clin Invest 81:782-790
57. Hunt G (1989) The role of laminin in cancer invasion and metastasis. Exp Cell Biol 57:165-176
58. Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11-25
59. Hynes RO, Lander AD (1992) Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68:303-322
60. Iwamoto Y, Robey FA, Graf J, Sasaki M, Kleinman HK, Yamada Y, Martin GR (1987) YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. Science 238:1132-1134
61. Jalkanen S, Jalkanen M (1992) Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. J Cell Biol 116:817-825
62. Juliano R (1994) Signal transduction by integrins and its role in the regulation of tumor growth. Cancer Metastasis Rev 13:25-30
63. Juliano RL, Haskill S (1993) Signal transduction from the extracellular matrix. J Cell Biol 120:577-585
64. Juliano RL, Varner JA (1993) Adhesion molecules in cancer: the role of integrins. Curr Biol 5:812-818
65. Juna EJ, Hitt AL (1992) Cytoskeleton-plasma membrane interactions. Science 258:955-963
66. Kadowaki T, Shiozaki H, Inoue M, Tamura S, Oka H, Doki Y, Iihara K, Matsui S, Iwazawa T, Nagafuchi A, Tsukita S, Mori T (1994) E-cadherin and α-catenin expression in human esophageal cancer. Cancer Res 54:291-296
67. Kelly CP, O'Keane JC, Orellana J, Schroy PC, Yang S, Lamont JT, Brady HR (1992) Human colon cancer cells express ICAM-1 in vivo and support LFA-1 dependent lymphocyte adhesion in vitro. Am J Physiol 263:864-870
68. Kim H, Yang XL, Rosada C, Hamilton SR, August JT (1994) CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation. Ach Biochem and Biophys 310:504-507
69. Kim WH, Schnaper W, Nomizu M, Yamada Y, Kleinman HK (1994) Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin. Cancer Res 54:5005-5010
70. Kinsella AR, Green B, Lepts GC, Hill CL, Bowie G, Taylor BA (1993) The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis. Br J Cancer 67:904-909
71. 1 chains in normal mucosa and adenomas of the colon and in colon carcinomas and their liver metastases. Am J Pathol 138:741-750
72. Koretz K, Schlag P, Quentmeier A, Möller P (1994) Evaluation of the secretory components as a prognostic variable in colorectal cancer. Int J Cancer 57:365-370
73. Koretz K, Möller P, Lehnert T, Hinz U, Otto HF, Herrfarth C (1995) Effect of CD44 on survival in colorectal carcinoma. Lancet 345:327-328
74. Lauri D, Needham L, Martin-Padura I, Dejana E (1991) Tumor cell adhesion to endothelial cells: endothelial leukocyte adhesion molecule-1 as an inducible adhesive receptor specific for colon carcinoma cells. J Natl Cancer Inst 83:1321-1324
75. Lauri D, Bertomeu MC, Orr FW (1990) Interleukin 1 increases tumor cell adhesion to endothelial cells through an RGD dependent mechanism: in vitro and in vivo studies. Clin Exp Metastasis 8:27-32
76. Lesley J, Hyman R, Kincade PW (1993) CD44 and its interaction with extracellular matrix. Adv Immunol 54:271-335
77. Liotta LA, Steeg PS, Stetler-Stevenson WG (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327-336
78. Löhr M, Trautmann B, Göttler M, Peters S, Zauner I, Maier A, Klöppel G, Liebe S, Kreuser ED (1996) Expression and function of receptors for extracellular matrix proteins in human ductal adenocarcinomas of the pancreas. Pancreas (in press)
79. Long MW (1992) Blood cell cytoadhesion molecules. Exp Hematol 20:288-301
80. Mackay CR, Terpe HJ, Stauder R, Marston WL, Stark H, Günthert U (1994) Expression and Modulation of CD44 variant isoforms in humans. J Cell Biol 124:71-82
81. r 32,000 laminin-binding protein messenger RNA in human colon carcinoma correlates with diseases progression. Cancer Res 50:3888-3891
82. Mai M, Brune K, Jacoby B, Kern HF, Mollenhauer J (1990) Laminin interactions with ductal pancreatic adenocarcinoma cells: identification of laminin- and collagen-binding proteins. J Cell Sci 95:65-74
83. Makgoba MW, Sanders ME, Shaw S (1989) The CD2-LFA3 and LFA-1-ICAM pathways: relevance to T-cell recognition. Immunol today 10:417-422
84. Makgoba MW, Bernard A, Sanders MEI (1992) Cell adhesion/signalling: biology and clinical applications. Eur J Clin Invest 22:443-453
85. Matsamura Y, Tarin D (1992) Significance of CD44 gene products for cancer diagnosis and disease evaluation. Lancet 340:1053-1058
86. Matsui S, Shiozaki H, Inoue M, Tamura S, Doki Y, Kadowaki T, Iwazawa T, Shimaya K, Nagafuchi A, Tsukita S (1994) Immunohistochemical evaluation of alpha-catenin in human gastric cancer. Virchows Arch 424:375-381
87. Mayer B, Johnson JP, Leitl F, Jauch KW, Heiss MM, Schildberg FW, Birchmeier W, Funke I (1993) E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 53:1690-1695
88. Mayer B, Jauch KW, Günthert U, Figdor CG, Schildberg FW, Funke I, Johnson JP (1993) De novo expression of CD44 and survival in gastric cancer. Lancet 342:1019-1022
89. Mecham RP (1991) Receptors for laminin mammalian cells. FASEB 5:2538-2546
90. Mollenhauer J, Röther J Kern HF (1987) Distribution of extracellular matrix proteins in pancreatic ductal adenocarcinoma and its influence on tumor cell proliferation in vitro. Pancreas 2:14-24
91. 6-containing CD44 proteins. Lancet 344:1470-1472
92. Nassal GJV (1994) Minimal residual disease as the target for immunotherapy of cancer. Lancet 343:1172-1173
93. Nigam AK, Savage FJ, Boulos PB, Stamp GWH, Liu D, Pignatelli M (1993) Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. Br J Cancer 68:507-514
94. Nomizu M, Yamamura K, Kleinman HK, Yamada Y (1993) Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance inhibition of tumor growth and metastasis. Cancer Res 53:3459-3461
95. Oda T, Kanai Y, Oyama T, Yoshiura K, Shimoyama Y, Birchmeier W, Sugimura T, Hirohashi S (1994) E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci 91:1858-1862
96. 2+ binding site of uvomorulin abolish the adhesive function. Cell 63:1033-1038
97. Packard BZ, Parry G (1994) Bone marrow activation by immobilized antibodies against tumor cells and immunocytes as a potential cancer immunotherapy. Biochem Biophys Acta 1224:395-400
98. Pauli BU, Lee CL (1988) Organ preference of metastasis: the role of organ-specifically modulated endothelial cells. Lab Invest 58:379-387
99. Pignatelli M, Smith MEF, Bodmer WF (1990) Low expression of collagen receptors in moderate and poorly differentiated colorectal adenocarcinomas. Br J Cancer 61:636-638
100. Pignatelli M, Liu D, Nasim NN, Stamp GWH, Hirano S, Takeichi M (1992) Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells. Br J Cancer 66:629-634
101. Pullman WE, Bodmer WF (1992) Cloning and characterization of a gene that regulates cell adhesion. Nature 356:529-532
102. Rivoltini L, Cattoretti G, Arienti F, Mastroianni A, Melani C, Colombo MP, Parmiani G (1991) The high lysability by LAK cells of colon-carcinoma cells resistant to doxorubicin is associated with a high expression of ICAM-1, LFA-3, NCA and a less differentiated phenotype. Int J Cancer 47:746-754
103. Rosendahl A, Neumann K, Chaloupka B, Rothmund M, Weinel RJ (1993) Expression and distribution of VLA receptors in the pancreas: an immunohistochemical study. Pancreas 8:711-718
104. Ruoslahti E (1992) Control of cell motility and tumor invasion by extracellular matrix interactions. Br J Cancer 66:239-242
105. Saiki I, Murata J, Iida J, Nishi N, Sugimura K, Azuma I (1989) The inhibition of murine lung metastasis by synthetic polypeptides [poly (Arg-Gly-Asp) and poly (Tyr-Ile-Gly-Ser-Arg)] with a core of cell adhesion molecules. Br J Cancer 59:194-197
106. 2. Cancer Res 51:903-906
107. Salmi M, Grön-Virta K, Sointu P, Grenman R, Kalimo H, Jalkanen S (1993) Regulated expression of exon v6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin. J Cell Biol 122:431-442
108. Schaller MD, Parsons JT (1994) Focal adhesion kinase and associated proteins. Curr Biol 6:705-710
109. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W (1991) E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51:6328-6337
110. Schlaepfer DD, Hanks SK, Hunter T, van der Geer P (1994) Integrin-mediated signal transduction linked to RAS pathway by GRB2 binding to focal adhesion kinase. Nature 372:786-791
111. Schwaebele W, Kerlin M, Meyer zum Büschemfelde KH, Dippold W (1993) De novo expression of intercellular adhesion molecule 1 (ICAM-1, CD54) in pancreas cancer. Int J Cancer 53:328-333
112. Seiter S, Arch R, Reber S, Komitowski, Hofmann M, Ponta H, Herrlich P, Matzku S, Zöller M (1993) Prevention of tumor metastasis formation by anti-variant CD44. J Exp Med 177:443-455
113. Sheperd NA, Saraga EP, Love SB, Jass JR (1989) Prognostic factors in colonic cancer. Histopathology 14:129-164
114. Shimoyama Y, Hirohashi S (1991) Expression of E- and P-cadherin in gastric carcinomas. Cancer Res 51:2185-2192
115. Sobel ME (1994) Differential expression of the 67 kDa laminin receptor in cancer. Semin Cancer Biol 4:311-317
116. Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425-433
117. Stallmach A, von Lampe B, Orzechowski HD, Matthes H, Riecken EO (1994) Increased fibronectin receptor expression in colon carcinoma-derived HT29 cells decreases tumorigenicity in nude mice. Gastroenterology 106:19-27
118. Stallmach A, v. Lampe B, Matthes H, Bornhöft G, Riecken EO (1992) Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation. Gut 33:342-346
119. Stallmach A, Riese HH, Schuppan D, Bornhöft G, Stein H, Riecken EO (1991) Identification of different laminin binding proteins in basolateral cell membranes of human colorectal carcinomas and normal colonic mucosa. Gut 32:282-286
120. Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TE (1988) Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52:925-933
121. Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenic regulator. Science 251:1451-169
122. Takeichi M (1993) Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 5:806-811
123. Tanabe KK, Ellis LM, Saya H (1993) Expression of CD44R1 adhesion molecule in colon carcinomas and metastases. Lancet 341:725-726
124. Tanaka Y, Adams DH, Hübscher S, Hirano H, Siebenlist S, Shaw S (1993) T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β. Nature 361:79-82
125. Terpe HJ, Starck H, Prehm P, Günthert U (1994) CD44 variant isoforms are preferentially expressed in basal epithelia of non-malignant human fetal and adult tissues. Histochem 101:79-89
126. Terranova V, Rao CN, Kalebic T, Margulies IM, Liotta LA (1983) Laminin receptors on human breast cancer cells. Proc Natl Acad Sci 80:444-448
127. Underhill C (1992) CD44: the hyaluron receptor. J Cell Sci 103:293-298
128. 3 as potential therapeutics for tumor angiogenesis. ASCO, Educational Book, pp 378-382
129. Van Roy F, Mareel M (1992) Tumor invasion: effects of cell adhesion and motility. Trends in Cell Biol 2:163-169
130. Vogelstein B, Kinzler KW (1993) The multistep nature of cancer. Trends in Genetics 9:138-141
131. 6-integrin receptors in pancreatic carcinoma. Int J Cancer 52:827-833
132. Whalen GF, Ingber DE (1989) Inhibition of tumor-cell attachment to extracellular matrix as amethod for preventing tumor recurrence in a surgical wound. Ann Surg 210:758-764
133. Wielenga VJM, Heider KH, Offerhaus GJA, Adolf GR, van den Berg FM, Ponta H, Herrlich P, Pals ST (1993) Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Res 53:4745-4765
134. Yamada KM, Kennedy DW, Yamada SS, Gralnick H, Chen WT, Akiyama SK (1990) Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration. Cancer Res 50:4485-4496
135. Yamumara K, Kibby MC, Jun SH, Kleinmann HK (1993) Effect of matrigel and laminin peptide YIGSR on tumor growth and matastasis. Semin Cancer Biol 4:259-265
136. Yow H, Wong JM, Chen HS, Lee C, Steele GD, Chen LB (1988) Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. Proc Natl Acad Sci 85:6394-6398
137. Zetter BR (1993) Adhesion molecules in tumor metastasis. Semin Cancer Biol 4:219-229
138. Zhu D, Cheng CF, Pauli BU (1991) Mediation of lung metastasis by a lung-specific endothelial cell adhesion molecule. Proc Natl Acad Sci 88:9568-9572
139. Zhu D, Cheng CF, Pauli BU (1992) Blocking of lung endothelial cell adhesion molecule-1 (Lu ECAM-1) inhibits murine melanoma lung metastasis. J Clin Invest 89:1718-1724
140. Zöller M (1995) CD44: physiological expression of distinct isoforms as evidence for organ specific metastasis formation. J Mol Med 73:425-438