Bulk cytokine production versus frequency of cytokine-producing cells in HIV1 infection before and during HAART

Clinical Immunology

Volumn 97, Issue 2, 2000, Pages 162-170

  Sousa, Ana E ^a   Chaves, Ana F ^a   Doroana, Manuela ^a   Antunes, Francisco ^a   Victorino, Rui M M ^a  

^a HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

Antiretroviral therapy; Cytokines; HIV; Immunological reconstitution; Intracellular cytokine detection

Indexed keywords

DIDANOSINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; LAMIVUDINE; NELFINAVIR; PHORBOL 13 ACETATE 12 MYRISTATE; STAVUDINE; ZIDOVUDINE;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOTHERAPY; MALE; PRIORITY JOURNAL;

EID: 0033778273     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2000.4930     Document Type: Article

References (32)

1. Host factors in the pathogenesis of HIV disease
2. Dual effect of interleukin 4 on HIV-1 expression: Implications for viral phenotypic switch and disease progression
3. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis
4. Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections
5. Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection
6. A TH1 → TH 2 switch is a critical step in the etiology of HIV infection
7. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals
8. Ability of HIV to promote a TH 1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells
9. The Th1-Th2 hypothesis of HIV infection: New insights
10. Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: Evidence for a major alteration within the CD8+ T cell subset
11. Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: Decreased IFN-gamma in the presence of preserved IL-4 production
12. Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry
13. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
14. Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level during highly active antiretroviral therapy for HIV-1 infection
15. Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: Possible implications for lymphocyte traffic and functional recovery
16. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
17. Cytokine flow cytometry: Understanding cytokine biology at the single-cell level
18. Measurement of intracellular cytokines
19. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging
20. Detection of intracellular cytokines by flow cytometry
21. Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation
22. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
23. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
24. Early reduction of immune activation in lymphoid tissue following highly active HIV therapy
25. IL-13 and IFN-gamma secretion by activated T cells in HIV-1 infection associated with viral suppression and a lack of disease progression
26. Effect of protease therapy on cytokine secretion by peripheral blood mononuclear cells (PBMC) from HIV-infected subjects
27. In vivo analysis of Fas/FasL interactions in HIV-infected patients
28. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
29. Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues
30. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28-T cells
31. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
32. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts