Defective function of the proteasome in autoimmunity: Involvement of impaired NF-κB activation

Diabetes Technology and Therapeutics

Volumn 2, Issue 3, 2000, Pages 415-428

  Hayashi, T ^a   Faustman, D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEASOME; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; AUTOIMMUNITY; DIABETES MELLITUS; DIABETOGENESIS; DNA BINDING; FEMALE; FETUS; LYMPHOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPLEEN CELL;

ANIMALS; AUTOIMMUNITY; CYSTEINE ENDOPEPTIDASES; DIABETES MELLITUS, TYPE 1; HUMANS; LYMPHOCYTES; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED NOD; MULTIENZYME COMPLEXES; NF-KAPPA B; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; SPLEEN; T-LYMPHOCYTES;

EID: 0033768698     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/15209150050194288     Document Type: Review

References (81)

1. Autoimmune diabetes mellitus in the BB rat
2. Prevention of type 1 diabetes
3. Breeding of a non-obese, diabetic strain of mice
4. Abnormal T lymphocyte subsets in type I diabetes mellitus: Analysis with anti-2H4 and anti-4B4 antibodies
5. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes
6. T-lymphocyte changes linked to autoantibodies: Association of insulin autoantibodies with CD4+CD45R+ lymphocyte subpopulation in prediabetic subjects
7. Defective maturation and function of antigen-presenting cells in Type I diabetes
8. Increase in simultaneous coexpression of naive and memory lymphocyte markers at diagnosis of IDDM
9. Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA linked genes
10. NOD mice are defective in proteasome production and activation of NF-κB
11. Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity
12. Reduced expression of peptide-loaded HLA class I molecules on multiple sclerosis lymphocytes
13. Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits
14. Immunoproteasome assembly: Cooperative incorporation of interferon γ (IFN-γ)-inducible subunits
15. Newly identified pair of proteasomal subunits regulated reciprocally by interferon-γ
16. Altered peptidase and viral-specific T cell response in LMP-2 mutant mice
17. + T cells in TAP-1 mutant mice
18. 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility complex class I
19. The B-cell specific transcription factor BSAP regulates B cell proliferation
20. Structure and function of the 20S and 26S proteasomes
21. Functions of the proteasome: The lysis at the end of the tunnel
22. Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins
23. Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7
24. Reduced expression of Tap1 and Lmp2 antigen processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter
25. The NF-κB and IκB proteins: New discoveries and insights
26. NF-kappa B: Ten years after
27. NF-kappa B: A lesson in family values
28. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
29. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
30. The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV
31. Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes
32. Kappa B site-dependent activation of the interleukin-2 alpha-chain gene promoter by human C-Rel
33. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
34. Expression of relB is required for the development of thymic medulla and dendritic cells
35. Inhibition of NF-κB activity results in disruption of the apical ectodermal ringe and aberrant limb morphogenesis
36. Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
37. Requirement for NF-κB in osteolast and B-cell development
38. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
39. Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb
40. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
41. IKK1-deficient mice exhibit abnormal development of skin and skeleton
42. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
43. Limb and skin abnormalities in mice lacking IKKalpha
44. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family
45. Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor κB1
46. Generation of p50 subunit of NF-κB processing of p105 through an ATP-dependent pathway
47. Co-translational biogenesis of NF-kappa B p50 by the 26S proteasome
48. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
49. Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65
50. NF-κB p105 processing via the ubiquitin-proteasome pathway
51. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB
52. Identification of a new serine kinase that activates NF-kappa B by direct phosphorylation
53. Oxireductive regulation of nuclear factor κB, involvement of a cellular reducing catalyst thioredoxin
54. TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105
55. Phosphorylation of p105 PEST sequences via a Redox-insensitive pathway up-regulates processing of p50 NF-κB
56. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50
57. Activation of NF-κB in vivo is regulated by multiple phosphorylations
58. Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation
59. Control of gene expression by proteolysis
60. Essential role of HLA-encoded proteasome subunits in NF-κB activation and prevention of TNF-α induced apoptosis
61. TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-kappaB
62. Embryonic lethality and liver degeneration in mice lacking the relA component of NF-kappa B
63. Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells
64. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice
65. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells
66. Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice
67. Use of donor β2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts
68. Tolerance to peripheral tissue is transient and maintained by tissue specific class I expression
69. CL. Oakley lecture. The pathogenesis of beta cell destruction in type I (insulin-dependent) diabetes mellitus
70. Examination of islets in the pancreas biposy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients
71. Overexpression of class I major histocompatibility complex accompanies insulitis in the nonobese diabetic mouse and is prevented by anti-interferon-γ antibody
72. IDDM in BB rats. Enhanced MHC class I heavy-chain gene expression in pancreatic islets
73. Protection of NIT-1 pancreatic beta-cells from immune attack by inhibition of NF-kappaB
74. Expression of transporter associated with antigen processing-1 in the endocrine cells of human pancreatic islets: Effect of cytokines and evidence of hyperexpression in IDDM
75. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats
76. The NOD mouse model of type 1 diabetes: As good as it gets?
77. A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways
78. cDNA cloning and interferon γ down-regulation of proteasomal subunits X and Y
79. Osteopetrosis in mice lacking NF-kappaB1 and NFkappaB2
80. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
81. B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching