The colorectal tumour suppressor APC is present in the NMDA-receptor-PSD-95 complex in the brain

Genes to Cells

Volumn 5, Issue 10, 2000, Pages 815-822

  Yanai, Hiroyuki ^a,b   Satoh, Kiyotoshi ^a,b   Matsumine, Akihiko ^a,b   Akiyama, Tetsu ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; COLON POLYPOSIS; COLORECTAL TUMOR; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEARNING; NERVE CELL PLASTICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; AMINO ACID MOTIFS; ANIMALS; BINDING, COMPETITIVE; BRAIN; BRAIN CHEMISTRY; COS CELLS; CYTOSKELETAL PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, N-METHYL-D-ASPARTATE; SURFACE PLASMON RESONANCE;

EID: 0033766161     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2000.00368.x     Document Type: Article

References (39)

1. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein
2. Wnt signaling: A common theme in animal development
3. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II
4. PDZ proteins organize synaptic signaling pathways
5. Synaptic targeting of glutamate receptors
6. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
7. Building synapses: Agrin and dystroglycan stick together
8. Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95
9. Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4
10. PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses
11. Binding of neuroligins to PSD-95
12. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins
13. SynGAP: A synaptic RasGAP that associates with the PSD-95/SAP90 protein family
14. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
15. + channels by interaction with a family of membrane-associated guanylate kinases
16. Lessons from hereditary colorectal cancer
17. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A
18. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
19. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102
20. Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domainbinding proteins to ATP and the membrane cytoskeleton
21. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
22. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
23. Signal transduction through beta-catenin and specification of cell fate during embryogenesis
24. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo
25. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein
26. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases
27. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90
28. The adenomatous polyposis coli (APC) tumor suppressor
29. Association of the APC gene product with beta-catenin
30. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
31. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
32. Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system
33. PDZs and receptor/channel clustering: Rounding up the latest suspects
34. Human postsynaptic density-95 (PSD95): Location of the gene (DLG4) and possible function in nonneural as well as in neural tissues
35. Association of the APC tumor suppressor protein with catenins
36. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density
37. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A
38. + channel Kv1.4
39. Enlightening the postsynaptic density