Overexpression of the glucose transporter gene with a herpes simplex viral vector protects striatal neurons against stroke

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 2, 1996, Pages 181-185

  Lawrence, Matthew S ^a   Sun, Guo Hua ^a   Kunis, David M ^a   Saydam, Tippi C ^a   Dash, Raj ^a   Ho, Dora Y ^a   Sapolsky, Robert M ^a   Steinberg, Gary K ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Gene transfer; Glucose transport; Herpes simplex; Hypoxia ischemia; Neuroprotection

Indexed keywords

VIRUS VECTOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE TRANSPORT; HERPES SIMPLEX VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRIATE CORTEX; STROKE;

EID: 9044254927     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199603000-00001     Document Type: Article

References (25)

1. Auer R, Siesjo B (1988) Biological differences between ischemia, hypoglycemia, and epilepsy. Ann Neurol 24:699-725
2. Beal M, Swartz K, Finn S, Mazurek M, Kowall N (1991) Neurochemical characterization of excitotoxic lesions in the cerebral cortex. J Neurosci 11:147-158
3. Betz AL, Gilboe DD, Drewes LR (1976) The characteristics of glucose transport across the blood brain barrier and its relation to glucose metabolism. In: Advances in Experimental Medicine and Biology (Levi G, Battistin L, Lajtha A, eds), New York, Plenum, pp 133-149
4. Betz AL, Iannoti F, Hoff JT (1983) Ischemia reduces blood-to-brain glucose transport in the gerbil. J Cereb Blood Flow Metab 3:200-206
5. Chen H, Chopp M, Schultz L, Bodzin G, Garcia J (1993) Sequential neuronal and astrocytic changes after transient middle cerebral artery occlusion in the rat. J Neurol Sci 118: 109-116
6. Dash R, Lawrence MS, Ho DY, Sapolsky RM (1995) A herpes simplex virus vector overexpressing the glucose transporter gene protects dentate gyrus neurons from an antimetabolite toxin. Exp Neurol (in press)
7. Farias L, Smith E, Markov A (1990) Prevention of ischemic-hypoxic brain injury and death in rabbits with fructose-1,6-diphosphate. Stroke 21:606-612
8. Ginsberg M, Welsh F, Budd M (1980) Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat. Stroke 11:347-355
9. Gjedde A (1980) Rapid steady-state analysis of blood-brain glucose transfer in rat. Acta Physiol Scand 108:331-339
10. Glorioso JC, Goins WF, Fink DJ (1992) Herpes simplex virus-based vectors. Semin Virol 3:265-276
11. Ho DY, Mocarski ES, Sapolsky RM (1993) Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene. Proc Natl Acad Sci USA 90:3,655-3,659
12. Ho DY, Fink SL, Lawrence MS, Meier TJ, Saydam TC, Dash R, Sapolsky RM (1994) Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects. J Neurosci Methods 57:205-215
13. Ho DY, Saydam TC, Fink SL, Lawrence MS, Sapolsky RM (1995) Defective herpes simplex virus vectors expressing the rat brain glucose transporter protect cultured neurons from necrotic insults. J Neurochem (in press)
14. Kraft SA, Larson CP, Shuer LM, Steinberg GK, Benson GV, Pearl RG (1990) Effect of hyperglycemia on neuronal changes in a rabbit model of focal cerebral ischemia. Stroke 21:447-450
15. Lawrence MS, Ho DY, Dash R, Sapolsky RM (1995) Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss. Proc Natl Acad Sci USA 92:7,247-7,251
16. Lee WH, Bondy CA (1993) Ischemic injury induces brain glucose transporter gene expression. Endocrinology 133: 2,540-2,560
17. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
18. Memezawa H, Minamisawa H, Smith ML, Siesjo BK (1992) Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res 89:67-78
19. Pulsinelli W, Waldman S, Rawlinson D, Plum F (1982) Moderate hyperglycemia augments ischemic brain damage: neuropathologic study in the rat. Neurology 32:1,239-1,245
20. Sapolsky RM (1992) Stress, the Aging Brain, and the Mechanisms of Neuron Death. Cambridge, MIT Press, pp 159-200
21. Schurr A, West C, Reid K, Tseng M, Reiss S, Rigor B (1987) Increased glucose improves recovery of neuronal function after cerebral hypoxia in vitro. Brain Res 421:135-140
22. Spaete RR, Frenkel N (1982) The herpes simplex virus amplicon: a new eukaryotic defective-virus cloning-amplifying vector. Cell 30:295-304
23. Tombaugh G, Sapolsky R (1990) Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia. J Cereb Blood Flow Metab 10:527-537
24. Yoon EJ, Steinberg GK (1994) Mild intraischemic hypothermia protects against focal cerebral ischemia. Soc Neurosci Abst 19:225
25. Zasslow MA, Pearl RG, Shuer LM, Steinberg GK, Lieberson RE, Larson CP (1989) Hyperglycemia decreases acute neuronal ischemic changes after middle cerebral artery occlusion in cats. Stroke 20:519-523