Adenovirus-mediated over-expression of interleukin-1 receptor antagonist reduces susceptibility to excitotoxic brain injury in perinatal rats

Neuroscience

Volumn 75, Issue 4, 1996, Pages 1033-1045

  Hagan, P ^a   Barks, J D E ^a   Yabut, M ^a   Davidson, B L ^d   Roessler, B ^b   Silverstein, F S ^a,c  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b Department of Internal Medicine ^*  (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

adenovirus; cytokine; excitotoxicity; interleukin 1; neuroprotection; NMDA

Indexed keywords

CYTOKINE; EXCITOTOXIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

ADENOVIRUS; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTOCHEMISTRY; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030298412     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(96)00225-4     Document Type: Article

References (46)

1. 1. Akli S., Caillaud C., Vigne E., Stratford-Perricaudet L. D. and Poenaru L. (1993) Transfer of a foreign gene into the brain using adenovirus vectors. Nat. Genet. 3, 224-228.
2. 2. Arend W. P. (1993) Interleukin-1 receptor antagonist. Adv. Immun. 54, 167-227.
3. 3. Bajocchi G., Feldman S. H., Crystal R. G. and Mastrangeli A. (1993) Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nat. Genet. 2, 229-234.
4. 4. Benveniste E. N. (1992) Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am. J. Physiol. 263, C1-C16.
5. 5. Betz A. L., Yang G. Y. and Davidson B. L. (1995) Attenuation of stroke size in rats using adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. J. cerebr. Blood Flow Metab. 15, 547-551.
6. 6. Bluthe R. M., Benadu C., Kelley K. W. and Dantzer R. (1995) Differential effects of Interleukin-1ra in sickness behavior and weight loss induced by interleukin-1 in rats. Brain Res. 677, 171-176.
7. 7. Brenneman D. E., Schultzberg M., Bartfai T. and Gozes I. (1992) Cytokine regulation of neuronal survival. J. Neurochem. 58, 454-460.
8. 8. Buttini M., Sauter A. and Boddeke H. W. (1994) Induction of interleukin-1 beta mRNA after focal cerebral ischemia in the rat. Brain Res. molec. Brain Res. 23, 126-134.
9. 9. Byrnes A. P., Rusby J. E., Wood M. J. A. and Charlton H. M. (1995) Adenovirus gene transfer causes inflammation in the brain. Neuroscience 66, 1015-1024.
10. 10. Davidson B. L., Allen E. D., Kozarsky K. F., Wilson J. M. and Roessler B. J. (1993) A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat. Genet. 3, 219-223.
11. 11. DeSimoni M. G., DelBo R., DeLuigi A., Simard S. and Forloni G. (1995) Central endotoxin induces different patterns of Interleukin-1 beta and Interleukin-6 messenger ribonucleic acid expression and Interleukin-6 secretion in the brain and periphery. Endocrinology 136, 897-902.
12. 12. Dinarello C. A. (1992) Interleukin-1 and Interleukin-1 antagonists. Blood 77, 1627-1652.
13. 13. Dripps D. J., Brandhuber B. C., Thompson R. C. and Eisenberg S. P. (1991) Interleukin-1 receptor antagonist binds to the 80k̃Da Interleukin-1 receptor, but does not initiate Interleukin-1 signal transduction. J. biol. Chem. 266, 10331-10336.
14. 14. Fan F. L., Young P. R., Barone F. C., Feuertein G. Z., Smith D. H. and McIntosh T. K. (1995) Experimental brain injury induces expression of interleukin-1beta mRNA in the rat brain. Molec. Brain Res. 30, 125-130.
15. 15. Feng L., Xia Y., Garcia G. E., Huang D. and Wilson C. B. (1995) Involvement of reactive oxygen intermediates in cyclooxygenase 2 expression induced by interleukin-1, tumor necrosis factor-α and lipopolysaccharide. J. clin. Invest. 95, 1669-1675.
16. 16. Giulian D. and Lachman L. B. (1985) Interleukin-1 stimulation of astroglial proliferation after brain injury. Science 228, 497-498.
17. 17. Giulian D., Baker T. J., Shin L. N. and Lachman L. B. (1986) Interleukin of the central nervous system is produced by ameboid microglia. J. exp. Med. 164, 594-604.
18. 18. Giulian D., Woodward J., Young P. G., Krebs J. F. and Lachman L. B. (1988) Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J. Neurosci. 8, 2485-2490.
19. 19. Graham F. L. and Prevec L. (1991) Manipulation of adenoviral vectors. In Methods in Molecular Biology (ed. Murray E. J.), pp. 109-128. Humana Press, Clifton, NJ.
20. 20. Hagan P., Poole S. and Bristow A. F. (1993) Endotoxin-stimulated production of rat hypothalamic interleukin-1 beta in vivo and in vitro, measured by specific immunoradiometric assay. J. molec. Endocr. 11, 31-36.
21. 21. Hagan P., Poole S. and Mistry Y. and Bristow A. F. (1994) Effect of Interleukin-10 and Interleukin-4 on CRF inhibition of endotoxin-stimulated Interleukin-1β and Interleukin-1 receptor antagonist. Proceedings of the European Endocrine Society, S34, Amsterdam.
22. 22. Kent S., Bluthe R. M., Dantzer R., Hardwick A. J., Kelley K. W., Rothwell N. J. and Vannice J. L. (1992) Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1. Proc. natn. Acad. Sci. U. S. A. 89, 9117-9120.
23. 23. Krueger J. M., Walter J., Dinarello C. A., Wolf S. M. and Chedul L. (1984) Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am. J. Physiol. 246, R994-999.
24. 24. Lee S. C., Dickson D. W., Liu W. and Brosnan C. F. (1993) Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-gamma. J. Neuroimmun. 46, 19-24.
25. 25. Libby P., Ordovas J. M., Auger K. R., Robbins A. H., Birinyi L. K. and Dinarello C. A. (1986) Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells. Am. J. Physiol. 124, 179-185.
26. 26. Lindholm D., Heumann R., Metyer M. and Thoenen H. (1987) Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330, 658-659.
27. 27. Liu T., McDonnell P. C., Young P. R., White R. F., Siren A. L., Hallenbeck J. M., Barone F. C. and Feuer-stein G. Z. (1993) Interleukin-1β mRNA expression in ischemic rat cortex. Stroke 24, 1746-1751.
28. 28. Martin D., Chinookoswong F. N. and Miller G. (1994) The interleukin-1 receptor antagonist (rhInterleukin-1ra) protects against cerebral infarction in a rat model of hypoxia-ischemia. Expl Neurol. 130, 362-367.
29. 29. McDonald J. W., Silverstein F. S. and Johnston M. V. (1988) Neurotoxicity of NMDA is markedly enhanced in developing rat central nervous system. Brain Res. 459, 200-203.
30. 30. McDonald J. W., Roeser N. F., Silverstein F. S. and Johnston M. V. (1989) Quantitative assessment of neuroprotection against NMDA-induced brain injury. Expl Neurol. 106, 289-296.
31. 31. McDonald J. W., Chen C. K., Trescher W. H. and Johnston M. V. (1991) The severity of excitotoxic brain injury is dependent on brain temperature in immature rat. Neurosci. Lett. 126, 83-86.
32. 32. Minami M., Kuraishi Y., Yamaguch T., Nakani S., Hirai Y. and Satoh M. (1990) Convulsants induce interleukin-1beta mRNA in rat brain. Biochem. biophys. Res. Commun. 171, 832-837.
33. 33. Minami M., Kuraishi Y., Yabuuchi K. and Yamazaki A. (1992) Induction of interleukin-1beta mRNA in rat brain after transient forebrain ischemia. J. Neurochem. 58, 390-392.
34. 34. Neve R. (1993) Adenovirus vectors enter the brain. Trends Neurosci. 16, 251-253.
35. 35. Ozaki M., Morii H., Qvist R. and Watanabe Y. (1994) Interleukin-1 beta induces phospholipase A2 in rat C6 glioma cell line. Biochem. biophys. Res. Commun. 205, 12-17.
36. 36. Relton J. K. and Rothwell N. J. (1992) Interleukin-1 receptor antagonist inhibits ischemic and excitotoxic neuronal damage in the rat. Brain Res. Bull. 29, 243-246.
37. 37. Roessler B. J., Hartman J. W., Latta J. M., Janich S. and Davison B. L. (1995) Inhibition of Interleukin-1 induced effects in synoviocytes transduced with the human Interleukin-1 receptor antagonist cDNA using an adenoviral vector. Human Gene Ther. 6, 307-316.
38. 38. Rothwell N. M. and Hopkins S. T. (1995) Cytokines and the nervous system. II. Actions and mechanisms of death. Trends Neurosci. 18, 130-136.
39. 39. Silverstein F. S., McDonald J. W., Bommarito M. and Johnston M. V. (1990) Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing brain. Stroke 21, 310-315.
40. 40. Strijbos P. J. and Rothwell N. J. (1995) Interleukin-1 beta attenuates excitatory amino acid induced neurodegeneration in vitro: involvement of nerve growth factor. J. Neurosci. 15, 3468-3474.
41. 41. Swanson R. A., Morton M. T., Tsao-Wu G., Savalos R. A., Davidson C. and Sharp F. R. (1990) A semiautomated method for measuring brain infarct volume. J. cerebr. Blood Flow Metab. 10, 290-294.
42. 42. Szaflarski J., Burtrum D. and Silverstein F. S. (1995) Cerebral hypoxia-ischemia stimulates cytokine gene expression in perinatal rats. Stroke 26, 1093-1100.
43. 43. Warren J. S. (1990) Interleukins and tumor necrosis factor in inflammation. Crit. Rev. clin. Lab. Sci. 28, 37-59.
44. 44. Wong D. and Dorovini-Zis K. (1992) Upregulation of intercellular adhesion molecule-1 (ICAM) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharides. J. Neuroimmun. 39, 11-22.
45. 45. Yamasaki Y., Shoozuhara H., Onodera H. and Kogure K. (1994) Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation. Acta neurochir. 60, Supp., 300-302.
46. 46. Yang Y., Ertl H. C. J. and Wilson J. M. (1994) MHC class I restricted cytotoxic lymphocytes to viral antigens destroy hepatocytes in mice infected with E1 deleted recombinant adenovirus. Immunity 1, 433-442.