The role of bone turnover markers and risk factors in the assessment of osteoporosis and fracture risk

Bailliere's Best Practice and Research in Clinical Endocrinology and Metabolism

Volumn 14, Issue 2, 2000, Pages 213-232

  Clowes, Jackie A ^a   Eastell, Richard ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Bone turnover markers; Osteoporosis; Osteoporotic fractures; Risk factors

Indexed keywords

ACID PHOSPHATASE; ALENDRONIC ACID; ALKALINE PHOSPHATASE BONE ISOENZYME; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CAFFEINE; COLLAGEN TYPE 1; CORTICOSTEROID; ESTROGEN; GLUCOCORTICOID; HORMONE; HYDROXYLYSINE; HYDROXYPROLINE; ISOENZYME; OSTEOCALCIN; PROTEIN; PSYCHOTROPIC AGENT; THIAZIDE DIURETIC AGENT; VITAMIN K GROUP; WARFARIN;

BONE DENSITY; BONE REMODELING; BONE TURNOVER; CLINICAL TRIAL; DISEASE ASSOCIATION; FALLING; FAMILY HISTORY; FRACTURE; HIGH RISK PATIENT; HUMAN; LIFESTYLE; META ANALYSIS; METABOLIC BONE DISEASE; MORPHOMETRICS; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; POPULATION RESEARCH; REVIEW; RISK ASSESSMENT; RISK FACTOR;

EID: 0033757627     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1053/beem.2000.0070     Document Type: Article

References (100)

1. Ju HS, Leung S, Brown B et al. Comparison of analytical performance and biological variability of three bone resorption assays. Clinical Chemistry 1997; 43(9): 1570-1576.
2. Blumsohn A & Eastell R. The performance and utility of biochemical markers of bone turnover: do we know enough to use them in clinical practice? Annals of Clinical Biochemistry 1997; 34: 449-459 (part 5).
3. Blumsohn A, Hannon RA & Eastell R. Biochemical assessment of skeletal activity. Physical Medicine and Rehabilitation Clinics of North America 1995; 6: 483-505.
4. Seibel MJ, Baylink DJ, Farley JR et al. Basic science and clinical utility of biochemical markers of bone turnover - a Congress report. Experimental and Clinical Endocrinology and Diabetes 1997; 105(3): 125-133.
5. Eastell R. Assessment of bone density and bone loss. Osteoporosis International 1996; 6 (supplement 2): 3-5.
6. Ravn P, Hosking D, Thompson D et al. Monitoring of alendronate treatment and prediction of effect on bone mass by biochemical markers in the early postmenopausal intervention cohort study. Journal of Clinical Endocrinology and Metabolism 1999; 84(7): 2363-2368.
7. Garnero P, Darte C & Delmas PD. A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover. Bone 1999; 24(6): 603-609.
8. Hannon R, Blumsohn A, Naylor K & Eastell R. Response of biochemical markers of bone turnover to hormone replacement therapy: impact of biological variability. Journal of Bone and Mineral Research 1998; 13(7): 1124-1133.
9. Braga de castro machado A, Hannon R & Eastell R. Monitoring alendronate therapy for osteoporosis. Journal of Bone and Mineral Research 1999; 14(4): 602-608.
10. Rosen HN, Moses AC, Garber J et al. Utility of biochemical markers of bone turnover in the follow-up of patients treated with bisphosphonates. Calcified Tissue International 1998; 63(5): 363-368.
11. Garnero P, Shih WJ, Gineyts E et al. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment, Journal of Clinical Endocrinology and Metabolism 1994; 79(6): 1693-1700.
12. Rosen CJ, Chesnut CH III & Mallinak NJ. The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation, Journal of Clinical Endocrinology and Metabolism 1997; 82(6): 1904-1910.
13. Riis BJ, Overgaard K & Christiansen C. Biochemical markers of bone turnover to monitor the bone response to postmenopausal hormone replacement therapy. Osteoporosis International 1995; 5(4): 276-280.
14. Riis BJ, Hansen MA, Jensen AM et al. Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone 1996; 19(1): 9-12.
15. Eastell R, Robins SP, Colwell T et al. Evaluation of bone turnover in type I osteoporosis using biochemical markers specific for both bone formation and bone resorption. Osteoporosis International 1993; 3(5): 255-260.
16. Garnero P, Sornay-Rendu E, Chapuy MC & Delmas PD. Increased bone turnover in late post-menopausal women is a major determinant of osteoporosis. Journal of Bone and Mineral Research 1996; 11(3): 337-349.
17. Parfitt AM, Mathews CH, Villnaueva AR et al. Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss, Journal of Clinical Investigation 1983; 72(4): 1396-1409.
18. Akesson K, Vergnaud P, Delmas PD & Obrant KJ. Serum osteocalcin increases during fracture healing in elderly women with hip fracture. Bone 1995; 16(4): 427-430.
19. Melton LJ, Khosla S, Atkinson EJ et al. Relationship of bone turnover to bone density and fractures. Journal of Bone and Mineral Research 1997; 12(7): 1083-1091.
20. Ravn P, Rix M, Andreassen H et al. High bone turnover is associated with low bone mass and spinal fracture in postmenopausal women. Calcified Tissue International 1997; 60(3): 255-260.
21. Garnero P, Hausherr E, Chapuy MC et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. Journal of Bone and Mineral Research 1996; 11(10): 1531-1538.
22. Vergnaud P, Garnero P, Meunier PJ et al. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study, Journal of Clinical Endocrinology and Metabolism 1997; 82(3): 719-724.
23. Szulc P, Chapuy MC, Meunier PJ & Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 1996; 18(5): 487-488.
24. Akesson K, Ljunghall S, Jonsson B et al. Assessment of biochemical markers of bone metabolism in relation to the occurrence of fracture: a retrospective and prospective population-based study of women. Journal of Bone and Mineral Research 1995; 10(11): 1823-1829.
25. van Daele PL, Seibel MJ, Burger H et al. Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study. British Medical Journal 1996; 312(7029): 482-483.
26. Garnero P, Dargent-Molina P, Hans D et al. Do markers of bone resorption add to bone mineral density and ultrasonographic heel measurement for the prediction of hip fracture in elderly women? The EPIDOS prospective study. Osteoporosis International 1998; 8(6): 563-569.
27. Marshall D, Johnell O & Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporosis fractures. British Medical Journal 1996; 312(7041): 1254-1259.
28. Cumming RG, Nevitt MC & Cummings SR. Epidemiology of hip fractures. Epidemiologic Reviews 1997; 19(2): 244-257.
29. Ross PD. Risk factors for osteoporotic fracture. Endocrinology and Metabolism Clinics of North America 1998; 27(2): 289-301.
30. Melton LJ. Epidemiology of spinal osteoporosis. Spine 1997; 22(supplement 24): 2S-11S.
31. Honkanen R, Tuppurainen M, Kroger H et al. Relationships between risk factors and fractures differ by type of fracture: a population-based study of 12,192 perimenopausal women. Osteoporosis International 1998; 8(1): 25-31.
32. Kelsey JL, Browner WS, Seeley DG et al. Risk factors for fractures of the distal forearm and proximal humerus. American Journal of Epidemiology 1992; 135: 477-489.
33. Mallmin H, Ljunghall S, Persson I & Bergstrom R. Risk factors for fractures of the distal forearm: a population-based case-control study. Osteoporosis International 1994; 4(6): 298-304.
34. Eddy DM, Johnston CC, Cummings SR et al. Osteoporosis: review of the evidence for prevention, diagnosis and treatment and cost effectiveness analysis. Osteoporosis International 1998; Supplement 4: S1-S88.
35. Nevitt MC, Rosen CJ, Glowacki J & Bilezikian JP (eds). The Aging Skeleton. San Diego: Academic Press, 1999.
36. Graafmans WC, Ooms ME, Hofstee HM et al. Falls in the elderly: a prospective study of risk factors and risk profiles. American Journal of Epidemiology 1996; 143(11): 1129-1136.
37. Parkkari J, Kannus P, Palvanen M et al. Majority of hip fractures occur as a result of a fall and impact on the greater trochanter of the femur: a prospective controlled hip fracture study with 206 consecutive patients. Calcified Tissue International 1999; 65(3): 183-187.
38. Norton R, Campbell AJ, Lee-Joe T et al. Circumstances of falls resulting in hip fractures among older people. Journol of the American Geriatrics Society 1997; 45(9): 1108-1112.
39. Durward G, Non PC, Ogunremi L et al. Detection of risk of falling and hip fracture in women referred for bone densitometry. Lancet 1999; 354(9174): 220-221.
40. Arden NK, Nevitt MC, Lane NE et al. Osteoarthritis and risk of falls, rates of bone loss, and osteoporotic fractures. Study of Osteoporotic Fractures Research Group. Arthritis and Rheumatism 1999; 42(7): 1378-1385.
41. Keen RW, Hart DJ, Arden NK et al. Family history of appendicular fracture and risk of osteoporosis: a population-based study. Osteoporosis International 1999; 10(2): 161-166.
42. Cummings SR, Nevitt MC, Browner WS et al. Risk factors for hip fracture in white women. Study of osteoporotic fractures research group. New England Journal of Medicine 1995; 332(12): 767-773.
43. Fox KM, Cummings SR, Powell-Threets K & Stone K. Family history and risk of osteoporotic fracture. Study of Osteoporotic Fractures Research Group. Osteoporosis International 1998; 8(6): 557-562.
44. Diaz MN, O'Neill TW & Silman AJ. The influence of family history of hip fracture on the risk of vertebral deformity in men and women: the European Vertebral Osteoporosis Study. Bone 1997; 20(2): 145-149.
45. Honkanen R, Tuppurainen M, Kroger H & Alhara E. Associations of early premenopausal fractures with subsequent fractures vary by sites and mechanisms of fractures. Calcified Tissue International 1997; 60: 327-331.
46. Torgerson DJ, Campbell MK, Thomas RE & Reid DM. Prediction of perimenopausal fractures by bone mineral density and other risk factors, Journal of Bone and Mineral Research 1996; 11(2): 293-297.
47. National Osteoporosis Foundation Working Group on Vertebral Fractures. Assessing vertebral fractures. Journal of Bone and Mineral Research 1995; 10(4): 518-523.
48. Black DM, Palermo L, Nevitt MC et al. Defining incident vertebral deformity: a prospective comparison of several approaches. The Study of Osteoporotic Fractures Research Group, Journal of Bone and Mineral Research 1999; 14(1): 90-101.
49. Ferrar L, Jiang G, Barrington NA & Eastell R. Identification of vertebral deformities in women: comparison of radiological assessment and quantitative morphometry using morphometric radiography and morphometric X-ray absorptiometry. Journal of Bone and Mineral Research 2000; 15(3): 575-585.
50. Black DM, Arden NK, Palermo L et al. Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research Group, Journal of Bone and Mineral Research 1999; 14(5): 821-828.
51. Melton LJ, Atkinson EJ, Cooper C et al. Vertebral fractures predict subsequent fractures. Osteoporosis International 1999; 10(3): 214-221.
52. Fujiwara S, Kasagi F, Yamada M & Kodama K. Risk factors for hip fracture in a Japanese cohort. Journal of Bone and Mineral Research 1997; 12(7): 998-1004.
53. Ismail AA, O'Neill TW, Cooper C & Silman AJ. Risk factors for vertebral deformities in men: relationship to number of vertebral deformities. European Vertebral Osteoporosis Study Group. Journal of Bone and Mineral Research 2000; 15(2): 278-283.
54. George GH & Patel S. Secondary prevention of hip fracture. Rheumatology (Oxford) 2000; 39(4): 346-349.
55. Dretakis KE, Dretakis EK, Papakitsou EF et al. Possible predisposing factors for the second hip fracture. Calcified Tissue International 1998; 62(4): 366-369.
56. Stewart A, Walker LG, Porter RW et al. Predicting a second hip fracture. Journal of Clinical Densitometry 1999; 2(4): 363-370.
57. Cuddihy MT, Gabriel SE, Crowson CS et al. Forearm fractures as predictors of subsequent osteoporotic fractures. Osteoporosis International 1999; 9(6): 469-475.
58. Gunnes M, Mellstrom D & Johnell O. How well can a previous fracture indicate a new fracture? A questionnaire study of 29,802 postmenopausal women. Acta Orthopaedica Scandinavica 1998; 69(5): 508-512.
59. Poor G, Atkinson EJ, O'Fallon WM & Melton LJ III. Predictors of hip fractures in elderly men. Journal of Bone and Mineral Research 1995; 10(12): 1900-1907.
60. O'Neill TW, Silman AJ, Naves DM et al. Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women. European Vertebral Osteoporosis Study Group. Osteoporosis International 1997; 7(1): 72-78.
61. Cooper C, Shah S, Hand DJ et al. Screening for vertebral osteoporosis using individual risk factors. Osteoporosis International 1991; 2: 48-53.
62. Santavirta S, Konttinen YT, Heliovaara M et al. Determinants of osteoporotic thoracic vertebral fracture - screening of 57,000 Finnish women and men. Acta Orthopaedica Scandinavica 1992; 63: 198-202.
63. Melton LJ, Atkinson EJ, Khosla S et al. Secondary osteoporosis and the risk of vertebral deformities in women. Bone 1999; 24(1): 49-55.
64. Vasquez H, Mazure R, Gonzalez D et al. Risk of fractures in celiac disease patients: a cross-sectional, case-control study. American Journal of Gastroenterology 2000; 95(1): 183-189.
65. Vestergaard P, Krogh K, Rejnmark L et al. Fracture risk is increased in Crohn's disease, but not in ulcerative colitis. Gut 2000; 46(2): 176-181.
66. Khosla S, Melton ILJ, Wermers RA et al. Primary hyperparathyroidism and the risk of fracture: a population-based study. Journal of Bone and Mineral Research 1999; 14(10): 1700-1707.
67. Dauphine RT, Riggs BL & Scholz DA. Back pain and vertebral crush fractures: an unemphasised mode of presentation for primary hyperparathyroidism. Annals of Internal Medicine 1975; 83: 365-367.
68. Stall GM, Harris S, Sokoll LJ & Dawson-Hughes B. Accelerated bone loss in hypothyroid patients over treated with L-thyroxine. Annals of Internal Medicine 1990; 113(4): 265-269.
69. Whooley MA, Kip KE, Cauley JA et al. Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group. Archives of Internal Medicine 1999; 159(5): 484-490.
70. Dargent-Molina P, Favier F, Grandjean H et al. Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet 1996; 348(9021): 145-149 [published erratum appears in Lancet 1996 Aug 10; 348(9024): 416].
71. Ramsey-Goldman R, Dunn JE, Dunlop DD et al. Increased risk of fracture in patients receiving solid organ transplants, Journal of Bone and Mineral Research 1999; 14(3): 456-463.
72. Melton LJ, Crowson CS, Khosla S et al. Fracture risk among patients with urolithiasis: a population-based cohort study. Kidney International 1998; 53(2): 459-464.
73. Aris RM, Renner JB, Winders AD et al. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Annals of Internal Medical 1998; 128(3): 186-193.
74. Freehill AK & Lenke LG. Severe kyphosis secondary to glucocorticoid-induced osteoporosis in a young adult with Cushing's disease. A case report and literature review. Spine 1999; 24(2): 189-193.
75. Greendale GA, Unger JB, Rowe JW & Seeman TE. The relation between cortisol excretion and fractures in healthy older people: results from the MacArthur studies-Mac. Journal of the American Geriatrics Society 1999; 47(7): 799-803.
76. Jamal SA, Stone K, Browner WS et al. Serum fructosamine level and the risk of hip fracture in elderly women: a case-cohort study within the study of osteoporotic fractures. American Journal of Medicine 1998; 105(6): 488-493.
77. Cummings SR, Browner WS, Bauer D et al. Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. New England Journal of Medicine 1998; 339(11): 733-738.
78. Ensrud KE, Duong T, Cauley JA et al. Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Study of Osteoporotic Fractures Research Group. Annals of Internal Medicine 2000; 132(5): 345-353.
79. Hesdorffer DC, Melton LJ, Malkasian GD et al. Hip fractures among infertile women. American Journal of Epidemiology 1999; 149(9): 810-813.
80. Michaelsson K, Baron JA, Farahmand BY et al. Oral-contraceptive use and risk of hip fracture: a case-control study. Lancet 1999; 353(9163): 1481-1484.
81. Cooper GS & Sandier DP. Long-term effects of reproductive-age menstrual cycle patterns on peri- and postmenopausal fracture risk. American Journal of Epidemiology 1997; 145(9): 804-809.
82. Jackson JA, Riggs MW & Spiekerman AM. Testosterone deficiency as a risk factor for hip fractures in men -a case-control study. American Journal of Medical Science 1992; 304: 4-8.
83. Boonen S, Vanderschueren D, Cheng XG et al. Age-related (type ii) femoral neck osteoporosis in men: biochemical evidence for both hypovitaminosis d- and androgen deficiency-induced bone resorption. Journal of Bone and Mineral Research 1997; 12(12): 2119-2126.
84. Eastell R, Reid DM, Compston J et al. A UK Consensus Group on management of glucocorticoid-induced osteoporosis: an update. Journal of Internal Medicine 1998; 244(4): 271-292.
85. Baltzan MA, Suissa S, Bauer DC & Cummings SR. Hip fractures attributable to corticosteroid use. Study of Osteoporotic Fractures Group. Lancet 1999; 353(9161): 1327.
86. Liu B, Anderson G, Mittmann N et al. Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 1998; 351(9112): 1303-1307.
87. Jones G, Nguyen T, Sambrook PN & Eisman JA. Thiazide diuretics and fractures: can meta-analysis help? Journal of Bone and Mineral Research 1995; 10(1): 106-111.
88. Caraballo PJ, Heit JA, Atkinson EJ et al. Long-term use of oral anticoagulants and the risk of fracture. Archires of Internal Medicine 1999; 159(15): 1750-1756.
89. Jamal SA, Browner WS, Bauer DC & Cummings SR. Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group. Annals of Internal Medicine 1998; 128(10): 829-832.
90. Joakimsen RM, Fonnebo V, Magnus JH et al. The Tromso Study: body height, body mass index and fractures. Osteoporosis International 1998; 8(5): 436-442.
91. Johnell O, O'Neill T, Felsenberg D et al. Anthropometric measurements and vertebral deformities. European Vertebral Osteoporosis Study (EVOS) group. American Journal of Epidemiology 1997; 146(4): 287-293.
92. Ensrud KE, Cauley J, Lipschutz R & Cummings SR. Weight change and fractures in older women. Study of Osteoporotic Fractures Research Group. Archives of Internal Medicine 1997; 157(8): 857-863.
93. Law MR & Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. British Medical Journal 1997; 315(7112): 841-846.
94. Cornuz J, Feskanich D, Willett WC & Colditz GA. Smoking, smoking cessation, and risk of hip fracture in women. American Journal of Medicine 1999; 106(3): 311-314.
95. Gregg EW, Cauley JA, Seeley DG et al. Physical activity and osteoporotic fracture risk in older women. Study of Osteoporotic Fractures Research Group. Annals of Internal Medicine 1998; 129(2): 81-88.
96. Silman AJ, O'Neill TW, Cooper C et al. Influence of physical activity on vertebral deformity in men and women: results from the European Vertebral Osteoporosis Study, Journal of Bone and Mineral Research 1997; 12(5): 813-819.
97. Norton R, Campbell AJ, Reid IR et al. Residential status and risk of hip fracture. Age and Ageing 1999; 28(2): 135-139.
98. Tromp AM, Ooms ME, Popp-Snijders C et al. Predictors of fractures in elderly women. Osteoporosis International 2000; 11(2): 134-140.
99. Burger H, De Laet CE, Weel AE et al. Added value of bone mineral density in hip fracture risk scores. Bone 1999; 25(3): 369-374.
100. Kanis JA, Johnell O, Oden A et al. Risk of hip fracture derived from relative risks: an analysis applied to the population of Sweden. Osteoporosis International 2000; 11(2): 120-127.