Differential expression and subcellular localization of murine BRCA1 and BRCA1-Δ11 isoforms in murine and human cell lines

International Journal of Cancer

Volumn 88, Issue 4, 2000, Pages 519-524

  Bachelier, Richard ^a,b   Venezia, Nicole Dalla ^a   Mazoyer, Sylvie ^a   Frappart, Lucien ^a   Lenoir, Gilbert M ^a   Vincent, Anne ^a  

^a CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER SUSCEPTIBILITY; CELL FRACTIONATION; CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOLECULAR CLONING; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING;

EID: 0033756048     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20001115)88:4<519::AID-IJC2>3.0.CO;2-R     Document Type: Article

References (35)

1. Mouse BRCA1: Localization, sequence analysis and identification of evolutionarily conserved domains
2. Isolation of the mouse homologue of brca1 and genetic mapping to mouse chromosome 11
3. Functions of the BRCA1 and BRCA2 genes
4. Transcriptional activation by BRCA1
5. Aberrant subcellular localization of BRCA1 in breast cancer
6. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
7. BRCA1 is localized in cytoplasmic tube-like invaginations in the nucleus
8. High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCA1-linked families
9. BRCA1 mutations in primary breast and ovarian carcinomas
10. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
11. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
12. Growth-retardation and tumor-inhibition by BRCA1
13. Brca1 is secreted and exhibits properties of a granin
14. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice
15. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
16. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53 and BRCA2/ p53 nullizygous embryos
17. Germline BRCA1 mutations and loss of the wild type allele in tumors from families with early-onset breast and ovarian-cancer
18. A strong candidate for the breast and ovarian-cancer susceptibility gene
19. A nuclear function for the tumor suppressor BRCA1
20. Isolation of EpH4 mammary epithelial cell subpopulations which differ in their morphogenetic properties
21. Advanced mammalian gene transfer: High titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
22. Production of high-titer helper-free retroviruses by transient transfection
23. BRCA1 is a cell cycle-regulated nuclear phosphoprotein
24. Location of BRCA1 in human breast and ovarian cancer cells
25. BRCA1 is a component of the RNA pol II holoenzyme
26. Dynamic changes of BRCA1 subnuclear localization and phosphorylation state are initiated by DNA damage
27. Association of BRCA1 with Rad51 in mitotic and meiotic cells
28. Murine Brca1: Sequence and significance for human missense mutations
29. Localization of BRCA1 and a splice variant identifies the nuclear localization signal
30. Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1
31. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
32. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b
33. Localization of human brca1 and its loss in high-grade non-inherited breast carcinomas
34. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
35. Conditional mutation of brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumor formation