Role of caveolae in cholesterol transport in arterial smooth muscle cells exposed to lipoproteins in vitro and in vivo

Laboratory Investigation

Volumn 78, Issue 7, 1998, Pages 825-837

  Thyberg, Johan ^a,c   Calara, Federico ^a   Dimayuga, Paul ^b   Nilsson, Jan ^a   Regnström, Jan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; MYELIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; ARTERY INJURY; ARTERY MUSCLE; ARTICLE; BALLOON CATHETER; CELL MEMBRANE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENDOSOME; FEMORAL ARTERY; LYSOSOME; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER;

EID: 0031818723     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Brown MS and Goldstein JL (1983). Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 52:223-261.
2. Brown MS and Goldstein JL (1986). A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47.
3. Brown MS and Goldstein JL (1997). The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331-340.
4. Calara F, Dimayuga P, Niemann A, Thyberg J, Diczfalusy U, Witztum JL, Palinski W, Shah PK, Cercek B, Nilsson J, and Regnström J (in press, 1998). An animal model to study the local oxidation of LDL and its biological effects in the arterial wall. Arterioscler Thromb Vasc Biol.
5. Campbell JH, Popadynec L, Nestel PJ, and Campbell GR (1983). Lipid accumulation in arterial smooth muscle cells. Influence of phenotype. Atherosclerosis 47:279-295.
6. Campbell JH, Reardon MF, Campbell GR, and Nestel PJ (1985). Metabolism of atherogenic lipoproteins by smooth muscle cells of different phenotype in culture. Arteriosclerosis 5:318-328.
7. Cercek B, Yamashita M, Dimayuga P, Zhu J, Fishbein MC, Kaul S, Shah PK, Nilsson J, and Regnström J (1997). Nuclear factor-κB activity and arterial response to balloon injury. Atherosclerosis 131:59-66.
8. Chait A, Ross R, Albers JJ, and Bierman EL (1980). Platelet-derived growth factor stimulates activity of low density lipoprotein receptors. Proc Natl Acad Sci USA 77:4084-4088.
9. Chao F-F, Blanchette-Mackie EJ, Dickins BF, Gamble W, and Kruth HS (1994). Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits. J Lipid Res 35:71-83.
10. Chao F-F, Blanchette-Mackie EJ, Tertov W, Skarlatos SI, Chen Y-J, and Kruth HS (1992). Hydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome. J Biol Chem 267:4992-4998.
11. Chung BH, Tallis G, Yalamoori V, Anantharamaiah GM, and Segrest JP (1994). Liposome-like particles isolated from human atherosclerotic plaques are structurally and compositionally similar to surface remnants of triglyceride-rich lipoproteins. Arterioscler Thromb 14:622-635.
12. Conrad PA, Smart EJ, Ying Y-S, Anderson RGW, and Bloom GS (1995). Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps. J Cell Biol 131:1421-1433.
13. Couet J, Li S, Okamoto T, Scherer PE, and Lisanti MP (1997). Molecular and cellular biology of caveolae. Paradoxes and plasticities. Trends Cardiovasc Med 7:103-110.
14. Fielding CJ, Bist A, and Fielding PE (1997). Caveolin mRNA levels are upregulated by free cholesterol. Proc Natl Acad Sci USA 94:3753-3758.
15. Fielding CJ and Fielding PE (1997). Intracellular cholesterol transport. J Lipid Res 38:1503-1521.
16. Fielding PE and Fielding CJ (1995). Plasma membrane caveolae mediate the efflux of cellular free cholesterol. Biochemistry 34:14288-14292.
17. Fielding PE and Fielding CJ (1996). Intracellular transport of low density lipoprotein derived free cholesterol begins at clathrin-coated pits and terminates at cell surface caveolae. Biochemistry 35:14932-14938.
18. Fowler S, Shio H, and Haley NJ (1979). Characterization of lipid-laden aortic cells from cholesterol-fed rabbits: IV Investigation of macrophage-like properties of aortic cell populations. Lab Invest 41:372-378.
19. Gong Q and Pitas RE (1995). Synergistic effects of growth factors on the regulation of smooth muscle cell scavenger receptor activity. J Biol Chem 270:21672-21678.
20. Hajjar DP and Haberland ME (1997). Lipoprotein trafficking in vascular cells. J Biol Chem 272:22975-22978.
21. Havel RJ, Eder HA, and Bragdon JH (1955). The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34:1345-1353.
22. Ikonen E (1997). Molecular mechanisms of intracellular cholesterol transport. Curr Opin Lipidol 8:60-64.
23. Inaba T, Gotoda T, Shimano H, Shimada M, Harada K, Kozaki K, Watanabe Y, Hoh E, Motoyoshi K, Yazaki Y, and Yamada N (1992). Platelet-derived growth factor induces c-fms and scavenger receptor genes in vascular smooth muscle cells. J Biol Chem 267:13107-13112.
24. Kruth HS (1997). The fate of lipoprotein cholesterol entering the arterial wall. Curr Opin Lipidol 8:246-252.
25. Kurzchalia TV, Dupree P, Parton RG, Kellner R, Virta H, Lehnert M, and Simons K (1992). VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J Cell Biol 118:1003-1014.
26. Lamaze C and Schmid SL (1995). The emergence of clathrin-independent pinocytic pathways. Curr Opin Cell Biol 7:573-580.
27. Li HM, Freeman MW, and Libby P (1995). Regulation of smooth muscle cell scavenger receptor expression by atherogenic diets and in vitro by cytokines. J Clin Invest 95:122-133.
28. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
29. Lupu F, Danaricu I, and Simionescu N (1987). Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions: A cytochemical and ultrastructural study. Atherosclerosis 67:127-142.
30. Mora R, Lupu F, and Simionescu N (1987). Prelesional events in atherogenesis. Colocalization of apolipoprotein B, unesterified cholesterol and extracellular phospholipid liposomes in the aorta of hyperlipidemic rabbit. Atherosclerosis 67:143-154.
31. Mora R, Simionescu M, and Simionescu N (1990). Purification and partial characterization of the extracellular liposomes isolated from the hyperlipidemic rabbit aorta. J Lipid Res 31:1793-1807.
32. Murata M, Peränen J, Schreiner R, Wieland F, Kurzchalia TV, and Simons K (1995). VIP21/caveolin is a cholesterol-binding protein. Proc Natl Acad Sci USA 92:10339-10343.
33. New RRC (1995). Influence of liposome characteristics on their properties and fate. In: Philippot JR and Schuber F, editors. Liposomes as tools in basic research and industry. Boca Raton: CRC Press, 3-20.
34. Nicholson AC and Hajjar DP (1992). Transforming growth factor-β up-regulates low density lipoprotein receptor-mediated cholesterol metabolism in vascular smooth muscle cells. J Biol Chem 267:25982-25987.
35. Oram JF and Yokoyama S (1996). Apolipoprotein-mediated removal of cellular cholesterol and phospholipids. J Lipid Res 37:2473-2491.
36. Owens GK (1996). Role of alterations in the differentiated state of vascular smooth muscle cells in atherogenesis. In: Fuster V, Ross R, and Topol EJ, editors. Atherosclerosis and coronary artery disease. Philadelphia: Lippincott-Raven Publishers, 401-420.
37. Penn MS, Rangaswamy S, Saidel GM, and Chisolm GM (1997). Macromolecular transport in the arterial intima: Comparison of chronic and acute injuries. Am J Physiol 272: H1560-H1570.
38. Penn MS, Saidel GM, and Chisolm GM (1994). Relative significance of endothelium and internal elastic lamina in regulating the entry of macromolecules into arteries in vivo. Circ Res 74:74-82.
39. Piha M, Lindstedt L, and Kovanen PT (1995). Fusion of proteolyzed low-density lipoprotein in the fluid phase: A novel mechanism generating atherogenic lipoprotein particles. Biochemistry 34:10120-10129.
40. Redgrave TG, Roberts DCK, and West CE (1975). Separation of plasma lipoproteins by density-gradient ultracentrifugation. Anal Biochem 65:42-49.
41. Regnström J, Nilsson J, Tornvall P, Landou C, and Hamsten A (1992). Susceptibility to low density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 339:1183-1186.
42. Ross R and Fuster V (1996). The pathogenesis of atherosclerosis. In: Fuster V, Ross R, and Topol EJ, editors. Atherosclerosis and coronary artery disease. Philadelphia: Lippincott-Raven Publishers, 441-460.
43. Roth M, Emmons LR, Perruchoud A, and Block LH (1991). Expressions of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes are stimulated by recombinant platelet-derived growth factor isomers. Proc Natl Acad Sci USA 88:1888-1892.
44. Schnitzer JE, Liu J, and Oh P (1995). Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J Biol Chem 270:14399-14404.
45. Schnitzer JE, Oh P, and McIntosh DP (1996). Role of GTP hydrolysis in fission of caveolae directly from plasma membranes. Science 274:239-242.
46. Shamir R, Johnson WJ, Morlock-Fitzpatrick K, Zolfaghari R, Li L, Mas E, Lombardo D, Morel DW, and Fisher EA (1996). Pancreatic carboxyl ester lipase: A circulating enzyme that modifies normal and oxidized lipoproteins in vitro. J Clin Invest 97:1696-1704.
47. Shio H, Haley NJ, and Fowler S (1979). Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester. Lab Invest 41:160-167.
48. Simionescu M and Simionescu N (1991). Endothelial transport of macromolecules: Transcytosis and endocytosis: A look from cell biology. Cell Biol Rev 25:5-78.
49. Smart EJ, Ying Y-S, Conrad PA, and Anderson RGW (1994). Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation. J Cell Biol 127:1185-1197.
50. Smart EJ, Ying Y-S, Donzell WC, and Anderson RGW (1996). A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane. J Biol Chem 271:29427-29435.
51. Sprinkle DJ and Subbiah MTR (1987). Studies on aorta during development. I. Fetal rabbit aorta under ex vivo and in vitro conditions: Rapid changes in smooth muscle cell phenotype, cell proliferation and cholesterol content with organ culture. Atherosclerosis 67:57-69.
52. Sprinkle DJ, Rymaszewski Z, Bydlowski S, Stevens C, Yunker R, and Subbiah MTR (1987). Studies on aorta during development. II. Differences in ontogeny of the key enzymes involved in cholesteryl synthesis and hydrolysis in rabbit aorta. Atherosclerosis 67:71-80.
53. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, and Wissler RW (1994). A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association. Circulation 89:2462-2478.
54. Steinberg D (1997). Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 272:20963-20966.
55. Thyberg J (1996). Differentiated properties and proliferation of arterial smooth muscle cells in culture. Int Rev Cytol 169:183-265.
56. Thyberg J (1998). Phenotypic modulation of smooth muscle cells during formation of neointimal thickenings following vascular injury. Histol Histopathol 13:871-891.
57. Thyberg J, Blomgren K, Hedin U, and Dryjski M (1995). Phenotype modulation of smooth muscle cells during the formation of neointimal thickenings in the rat carotid artery after balloon injury: An electron-microscopic and stereological study. Cell Tissue Res 281:421-433.
58. Thyberg J, Hedin U, and Bottger BA (1990). Attachment substrates for smooth muscle cells. In: Piper HM, editor. Cell culture techniques in heart and vessel research. Berlin: Springer-Verlag, 315-333.
59. Thyberg J, Palmberg L, Nilsson J, Ksiazek T, and Sjölund M (1983). Phenotype modulation in primary cultures of arterial smooth muscle cells: On the role of platelet-derived growth factor. Differentiation 25:156-167.
60. Thyberg J, Roy J, Tran PK, Blomgren K, Dumitrescu A, and Hedin U (1997). Expression of caveolae on the surface of rat arterial smooth muscle cells is dependent on the phenotypic state of the cells. Lab Invest 77:93-101.
61. Vasile E, Simionescu M, and Simionescu N (1983). Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ. J Cell Biol 96:1677-1689.
62. Wight TN (1996). The vascular extracellular matrix. In: Fuster V, Ross R, and Topol EJ, editors: Atherosclerosis and coronary artery disease. Philadelphia: Lippincott-Raven Publishers, 421-440.