Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome

Autoimmunity

Volumn 25, Issue 4, 1997, Pages 203-211

  Morgenthaler, Nils G ^a   Seissler, Jochen ^a   Achenbach, Peter ^a   Glawe, Daniela ^a   Payton, Mark ^b   Meinck, Hans Michael ^c   Christie, Michael R ^b   Scherbaum, Werner A ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Autoantibodies; Glutamic acid decarboxylase; IA 2; Insulin dependent diabetes mellitus; Stiff man syndrome

Indexed keywords

AUTOANTIBODY; ENZYME ANTIBODY; GLUTAMATE DECARBOXYLASE; PROTEIN TYROSINE PHOSPHATASE;

ADULT; AGED; ARTICLE; ENDOCRINE DISEASE; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MULTIPLE ENDOCRINE ADENOMATOSIS; STIFF MAN SYNDROME;

EID: 0030873872     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939708994729     Document Type: Article

References (36)

1. Bonifacio, E., Bingley, P. J., Shattock, M., et al. (1990). Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes, Lancet, 335, 147-149.
2. Riley, W. J., Maclaren, N. K., Krischer, J., et al. (1990). A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes, N. Engl. J. Med., 323, 1167-1172.
3. Bonifacio, E., Boitard, C., Gleichmann, H., Shattock, M. A., Molenaar, L. J. and Bottazzo, G. F. (1990). Assessment of precision, concordance, specificity and sensitivity of islet cell antibody measurement in 41 assays, Diabetologia, 33, 731-736.
4. Greenbaum, C. J., Palmer, J. P., Nagataki, S. et al. (1992). Improved specificity of ICA assays in the Fourth International Immunology of Diabetes serum exchange Workshop, Diabetes, 41, 1570-1574.
5. Roll, U., Christie, M. R., Standl, E. and Ziegler, A. G. (1994). Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of Type 1 diabetic patients, Diabetes, 43, 154-160.
6. Tuomilehto, J., Zimmet, P., Mackay, I. R., et al. (1994). Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease, Lancet, 343, 1383-1385.
7. Christie, M., Tun, R. Y. M., Lo, S. S. S., et al. (1992). Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies in identical twins, Diabetes, 41, 782-787.
8. Christie, M., Tun, R. Y. M., Lo, S. S. S., et al. (1993). Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase, J. Clin. Invest., 92, 240-248.
9. Bingley, P. J., Christie, M. R., Bonifacio, E., et al. (1994). Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives, Diabetes, 43, 1304-1310.
10. Christie, M., Genovese, S., Cassidy, D., et al. (1994). Antibodies to islet 37 K antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity, Diabetes, 43, 1254-1259.
11. Bonifacio, E., Genovese, S., Braghi, S., et al. (1995). Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity, Diabetologia, 38, 816-822.
12. Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995). Relationship of the 37,000- and 40,000Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512), J. Clin. Invest., 96, 1506-1511.
13. Lan, S. M., Lu, J., Goto, Y. and Notkins, A. L. (1994). Molecular Cloning and Identification of a Receptor-Type Protein Tyrosine Phosphatase, IA-2, from Human Insulinoma, DNA and Cell Biology, 13, 505-514.
14. Grubin, C. E., Daniels, T, Toivola, B., et al. (1994). A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM, Diabetologia, 37, 344-350.
15. Scherbaum, W. A., Mirakian, R., Pujol-Borrell, R., Dean, B. M. and Bottazzo, G. F. (1986). Immunochemistry in the study and diagnosis of organ-specific autoimmune disease. In: Polak JM, Van Noorden S, eds. Immuncytochemistry. Modern Methods and Applications. U.K.: Wright Bistrol; 456-476.
16. Petersen, J. S., Hejnaes, K. R., Moody, A., et al. (1994). Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay, Diabetes, 43, 459-467.
17. Bonifacio, E., Lampasona, V., Genovese, S. et al. (1995). Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40 k autoantigen and a target of islet-cell antibodies, J. Immunol., 155, 5419-5426.
18. Lu, J., Li, Q., Xie, H. et al. (1996). Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37-kDa tryptic fragment, Proc. Natl. Ac. Sci., 93, 2307-2311.
19. Hawkes, C. J., Wasmeier, C, Christie, M. R. and Hutton, J. C. (1996). Identification of the 37 k-antigen in insulin-dependent diabetes as a tyrosine phosphatase-like protein (phogrin) related to IA-2, Diabetes, 45, 1187-1192.
20. Lan, M. S., Wasserfall, C., Maclaren, N. K. and Notkins, A. L. (1996). IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus, Proc. Natl. Acad. Sci., 93, 6367-6370.
21. Gianani, R., Rabin, D. U., Verge, C. F., et al. (1995). ICA512 autoantibody radioassay, Diabetes, 44, 1340-1344.
22. Rabin, D. U., Pleasic, S. M., Shapiro, J. A., et al. (1994). Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases, J. Immunology., 152, 3183-3188.
23. Myers, M. A., Rabin, D. U. and Rowley, M. J. (1995). Pancreatic Islet cell antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase, Diabetes, 44, 1290-1295.
24. Lampasona, V., Bearzatto, M., Genovese, S., Bosi, E., Ferrari, M. and Bonifacio, E. (1996). Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the proein tyrosine phosphatase-like IA-2 autoantigen, J. Immunol., 157, 2707-2711.
25. Hagopian, W. A., Sanjeevi, C. B., Kockum, I., et al. (1995). Glutamate decarboxylase-, insulin-, and islet cell antibodies and HLA typing to detect diabetes in a general populationbased study of Swedish children, J. Clin. Invest., 95, 1505-1511.
26. Seissler, J., Amann, J., Mauch, L., et al. (1993). Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus, J. Clin. Invest., 92, 1394-1399.
27. Verge, C. F., Howard, N. J., Rowley, M. J., et al. (1994). Anti-glutamate decarboxylase and other antibodies at the onset of childhood IDDM: a population-based study, Diabetologia, 37, 1113-1120.
28. Verge, C. F., Gianani, R., Kawasaki, E., Liping, Y., Pietropaolo, M., Jackson, R. A., Chase, H. P. and Eisenbarth, G. S. (1996). Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512 bdc/IA-2 autoantiodies, Diabetes, 45, 926-933.
29. Seissler, J., Morgenthaler, N. G., Achenbach, P., et al. (1996). Combined screening for autoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM, Diabetologia, 39, 1351-1356.
30. Wagner, R., Genovese, S., Bosi, E., et al. (1994). Slow metabolic deterioration towards diabetes in islet cell antibody positive patients with autoimmune polyendocrine disease, Diabetologia, bf 37, 365-371.
31. Seissler, J., Bieg, S., Yassin, N., et al. (1994). Association between antibodies to the Mr 67,000 isoform of Glutamate Decarboxylase (GAD) and Type 1 (insulin-dependent) diabetes mellitus with coexisting Autoimmune Polyendocrine Syndrome Type II, Autoimmunity, 19, 231-238.
32. Solimena, M., Folli, F., Aparisi, R., Pozza, G. and De Camilli, P. (1990). Autoantibodies to GABAergic neurons and pancreatic beta cells in stiff-man syndrome, N. Engl. J. Med., 322, 1555-1560.
33. Meinck, H. M., Ricker, K., Hülser, P. J., Schmid, E., Peiffer, J. and Solimena, M. (1994). Stiff man syndrome: clinical and laboratory findings in eight patients, J. Neurol., 241, 157-166.
34. Kim, J., Namchuk, M., Bugawan, T., et al. (1994). Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus, J. Exp. Med., 180, 595-606.
35. Martino, G., Grimaldi, L. M. E., Bazzigaluppi, E., Passini, N., Sinigaglia, F. and Rogge, L. (1996). The insulindependent diabetes mellitus-associated ICA 105 autoantigen in stiff-man syndrome patients, J. Neuroimmunol., 69, 129-134.
36. Folli, F., Solimena, M., Cofiell, R. et al. (1993). Autoantibodies to a 128 kD synaptic protein in stiff-man syndrome with breast cancer, N. Engl. J. Med., 228, 564-551.