Combined screening for antoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM

Diabetologia

Volumn 39, Issue 11, 1996, Pages 1351-1356

  Seissler, J ^a   Morgenthaler, N G ^a   Achenbach, P ^a   Lampeter, E F ^b   Glawe, D ^a   Payton, M ^c   Christie, M ^c   Scherbaum, W A ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antibodies to tyrosine phosphatase IA 2; GAD antibodies; Insulin dependent diabetes mellitus; Islet cell antibodies; Prediction

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; BIOLOGICAL MARKER; PANCREAS ISLET CELL ANTIBODY; PROTEIN TYROSINE PHOSPHATASE; RECOMBINANT PROTEIN;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; AGE DISTRIBUTION; COMPARATIVE STUDY; FAMILY; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW UP; IMMUNOLOGY; MIDDLE AGED; PANCREAS ISLET; PRESCHOOL CHILD; PREVALENCE; RADIOASSAY; RISK FACTOR;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AUTOANTIBODIES; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FAMILY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FOLLOW-UP STUDIES; GLUTAMATE DECARBOXYLASE; HUMANS; INFANT; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; PREVALENCE; PROTEIN-TYROSINE-PHOSPHATASE; RADIOLIGAND ASSAY; RECOMBINANT PROTEINS; RISK FACTORS;

EID: 0030280835     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050582     Document Type: Article

References (27)

1. Tarn AC,Thomas JM, Dean BM et al. (1988) Predicting insulin-dependent diabetes. Lancet i: 845-850
2. Bonifacio E, Bingley PJ, Shattock M et al. (1990) Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335: 147-149
3. Riley WJ, MacLaren NK, Kirscher N et al. (1990) A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 323: 1167-1172
4. Bingley PJ, Christie MR, Bonifacio E et al. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43: 1304-1310
5. Bonifacio E, Boitard C, Gleichmann H, Shattock MA, Molenaar LJ, Bottazzo GF (1990) Assessment of precision, concordance, specificity and sensitivity of islet cell antibody measurement in 41 assays. Diabetologia 33: 731-736
6. Greenbaum CJ, Palmer JP, Nagataki S et al. (1992) Improved specificity of ICA assays in the Fourth International Immunology of Diabetes serum exchange Workshop. Diabetes 41: 1570-1574
7. Roll U, Christie MR, Standl E, Ziegler A (1994) Associations of anti-G AD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type 1 diabetic patients. Diabetes 43: 154-160
8. r 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired beta-cell function. Diabetologia 35: 550-554
9. r. 64,000 islet cell protein, and antibodies to glutamate decarboxylase in subjects at risk for IDDM. Diabetologia 37: 491-499
10. Christie MR, Tun RYM, Lo SSS et al. (1992) Antibodies to GAD and tryptic fragments of islet 64 K antigen as distinct markers for development of IDDM. Diabetes 41: 782-786
11. Christie M, Genovese S, Cassidy D et al. (1994) Antibodies to islet 37 K antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes 43: 1254-1259
12. Bonifacio E, Genovese S, Braghi S et al. (1995) Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 38: 816-822
13. 65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population. Diabetologia 37: 917-924
14. Yu L, Gianani R, Eisenbarth GS (1994) Quantitation of glutamic acid decarboxylase autoantibody levels in prospectively evaluated relatives of patients with type 1 diabetes. Diabetes 43: 1229-1233
15. Schott M, Schatz D, Atkinson M et al. (1994) GAD65 autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus. J Autoimmun 7: 865-872
16. Christie M, Hollands JA, Brown TJ, Michelsen BK, Delovitch TL (1993) Detection of pancreatic islet 64,000 Mr autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. J Clin Invest 92: 240-248
17. Payton MA, Hawkes CJ, Christie MR (1995) Relationship of the 37,000- and 40,000 Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 96: 1506-1511
18. Lan MS, Goto Y, Notkins AL (1994) Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 5: 505-514
19. Grubin CE, Daniels T, Toivola B et al. (1994) A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37: 344-350
20. Scherbaum WA, Mirakian R, Pujol-Borrell R, Dean BM, Bottazzo GF (1986) Immunochemistry in the study and diagnosis of organ-specific autoimmune disease. In: Polak JM, Van Noorden S (eds) Immunochemistry. Modern methods and applications. Wright, Bistrol; pp 456-476
21. Ongagna CJ, Marchal-Levy C (1995) Anti-37kDa antibodies are associated with the development of IDDM in individuals with islet cell antibodies. Diabetologia 38: 370-375
22. Seissler J, Amann J, Mauch L et al. (1993) Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 92: 1394-1399
23. Schmidli RS, Colman PG, Bonifacio E, and participating laboratories (1995) Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The second international GADAb workshop. Diabetes 44: 636-640
24. Gianini R, Rabin DU, Verge CF et al. (1995) ICA512 autoantibody radioassay. Diabetes 44: 1340-1344
25. Verge CF, Howard NJ, Rowley MJ et al. (1994) Anti-glutamate decarboxylase and other antibodies at the onset of childhood IDDM: a population-based study. Diabetologia 37: 1113-1120
26. Hagopian WA, Sanjeevi CB, Kockum I et al. (1995) Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95: 1505-1511
27. 65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43: 459-467