Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and β-chemokines

Journal of Infectious Diseases

Volumn 182, Issue 6, 2000, Pages 1625-1635

  Vila, Jordi ^a   Vargas, Martha ^a   Henderson, Ian R ^b   Gascon, Joaquim ^a   Nataro, James ^b  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; AMPRENAVIR; AZATHIOPRINE; BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; DIDANOSINE; FISH OIL; FOLIC ACID; HYDROXYUREA; LAMIVUDINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MERCAPTOPURINE; MESALAZINE; NELFINAVIR; PREDNISONE; RANTES; RITONAVIR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

ARTICLE; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; ENTERITIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; LAMINA PROPRIA; MUCOSA INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM MUCOSA; SIGMOID; T LYMPHOCYTE;

BIOPSY; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; LYMPHOCYTE COUNT; MACROPHAGE INFLAMMATORY PROTEIN-1; RANTES; RECEPTORS, CCR5; RECEPTORS, CXCR4; T-LYMPHOCYTES;

EID: 0033715824     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/317625     Document Type: Article

References (51)

1. Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes
2. Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T-cell activation
3. HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28
4. + memory T cells by human immunodeficiency virus type 1: Evidence for a role in the selective T-cell functional defects observed in infected individuals
5. Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro
6. + T cells
7. Lymphoid organs function as major reservoirs for human immunodeficiency virus
8. +) T cells are rapidly eliminated in early SIV infection in vivo
9. Immunopathology of human immunodeficiency virus infection in the gastrointestinal tract
10. Identification of HIV-1 viral RNA in intestinal tissue from patients with early and late HIV infection
11. Detection, localization, and quantitation of HIV-associated antigens in intestinal biopsies from patients with HIV
12. CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
13. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
14. Chemokines and HIV-1 second receptors. Confluence of two fields generates optimism in AIDS research
15. An inducible transcription factor activates expression of human immunodeficiency virus in T cells
16. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
17. Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue
18. Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection
19. Immunopathogenesis of HIV infection
20. + lymphocytes in vivo
21. Regulation of CCR5 and CXCR4 expression by type 1 and type 2 cytokines: CCR5 expression is downregulated by IL-10 in CD4-positive lymphocytes
22. Intestinal mucosal inflammation associated with human immunodeficiency virus infection
23. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCRS) for RANTES, MIP-β, and MIP-1α
24. The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4
25. Chemokines and tissue injury
26. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
27. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyper-responsiveness
28. Chemokines: Chemotactic cytokines that mediate inflammation
29. The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease
30. 1993 Evised classification system for HIV infection and expanded surveillance of definition for AIDS among adolescents and adults
31. + T lymphocytes as a biological calibrator
32. Early reduction of immune activation in lymphoid tissue following highly active HIV therapy
33. Targeted suppression of cytokine production in monocytes but not in T lymphocytes by a tetravalent guanylhydrazone (CNI-1493)
34. Cellular localization of the chemokine receptor CCR5: Correlation to cellular targets of HIV-1 infection
35. Repertoire of chemokine receptor expression in the female genital tract: Implications for human immunodeficiency virus transmission
36. + T cell surface CCR5 density as a determining factor of virus load in persons infected with human immunodeficiency virus type 1
37. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
38. + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen
39. Viral dynamics in human immunodeficiency virus type 1 infection
40. + T cell turnover
41. + T-cell turnover in HIV-1 infection: A paradigm revisited
42. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
43. TNF-α inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression
44. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
45. Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines
46. RANTES, macrophage-inhibitory protein 1α, and the eosinophil product major basic protein are released into upper respiratory secretions during virus-induced asthma exacerbations in children
47. Increase in IL-8, IL-10, IL-13, and RANTES mRNA levels (in situ hybridization) in the nasal mucosa after nasal allergen provocation
48. Up-regulation of β-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates
49. Alterations in RANTES gene expression and T-cell prevalence in intestinal mucosa during pathogenic or nonpathogenic simian immunodeficiency virus infection
50. The level of RANTES expression and HIV-1 replication in the lymphoid tissues of HIV-1-infected acute and chronic patients [poster 393]
51. Loss of mucosal CD4 lymphocytes is an early feature of HIV infection