Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats

Hypertension

Volumn 36, Issue 5, 2000, Pages 734-739

  Zagato, Laura ^a   Modica, Rossana ^b   Florio, Monica ^b   Torielli, Lucia ^b   Bihoreau, Marie Thérèse ^c   Bianchi, Giuseppe ^a   Tripodi, Grazia ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b Prassis Sigma Tau Research Institute   (Italy)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Genes; Hypertension, essential; Rats, inbred strains

Indexed keywords

ADDUCIN; ALPHA 1B ADRENERGIC RECEPTOR; CARRIER PROTEIN;

ADOLESCENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CAROTID ARTERY; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 14; GENE MAPPING; GENETIC LINKAGE; GENETIC MARKER; HYPERTENSION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; QUANTITATIVE TRAIT; RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0033711961     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.36.5.734     Document Type: Article

References (50)

1. The Milan hypertensive strain: A description of the model
2. A linkage map of the rat genome derived from three F2 crosses
3. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat
4. A radiation hybrid map of the rat genome containing 5255 markers
5. Lessons from experimental genetic hypertension
6. Two point mutations within the adducin genes are involved in blood pressure variation
7. α-Adducin polymorphism in primary hypertension: Linkage and association study; relationship to salt sensitivity
8. Hypertension associated point-mutations in the adducin α and β subunits affect actin cytoskeleton and ion transport
9. +-ATPase: Relation to genetic hypertension
10. Alpha-adducin polymorphisms and renal sodium handling in essential hypertensive patients
11. Adducin polymorphism affects renal proximal tubule reabsorption in hypertension
12. Rat gene mapping using PCR-analyzed microsatellites
13. Map of seven polymorphic markers on rat chromosome 14: Linkage conservation with human chromosome 4
14. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
15. +-ATPase α1 genes in the Milan hypertensive rat
16. Polymorphisms in the carboxy-terminus of the epithelial sodium channel in rat models for hypertension
17. Glucocorticoid receptor polymorphism in genetic hypertension
18. Polymorphism of γ-adducin in genetic hypertension and mapping of the gene to rat chromosome 1q55
19. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10
20. Assignment of the rat 11b-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to rat chromosome 7 using rat-mouse somatic ceil hybrids
21. MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
22. Systematic detection of errors in genomic linkage data
23. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
24. Genetic analysis of blood pressure in the Milan hypertensive strain of rat (Rattus norvegicus)
25. PST2238: A new antihypertensive compound that modulates Na, K-ATPase in genetic hypertension
26. Alpha adducin gene polymorphism and cardiovascular phenotypes in a general population
27. Polymorphism of α-adducin and hypertension
28. No association between α-adducin 460 polymorphism and essential hypertension in a Japanese population
29. Lack of association between the alpha-adducin locus and essential hypertension in the Japanese population
30. The Gly460Trp variant of α-adducin is not associated with hypertension in white Anglo-Australians
31. The role of α-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study
32. Renal disease susceptibility and hypertension under independent genetic control in the fawn-hooded rat
33. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1
34. Role of the α-, β-, and γ-subunits of epithelial sodium channel in a model of polygenic hypertension
35. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, 18
36. + exchanger kinase has increased activity in spontaneously hypertensive rat vascular smooth muscle cells
37. + exchanger
38. Hypertension: Genes and environment
39. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats
40. Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats
41. A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes
42. Hypotension induced by interleukin-3 in patients on angiotensin-converting enzyme inhibitors
43. Linkage and association of adrenergic and dopamine receptor genes in the distal portion of the long arm of chromosome 5 with systolic blood pressure variation
44. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings
45. Decreased blood pressure response in mice deficient of the alpha(1b)-adrenergic receptor
46. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10
47. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17
48. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
49. A high-resolution radiation hybrid map of the proximal region of rat chromosome 4
50. Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension