Genetic analysis of the S(A) and Na+/K+-ATPase α1 genes in the Milan hypertensive rat

Journal of Hypertension

Volumn 16, Issue 2, 1998, Pages 139-144

  Lodwick, David ^a   Zagato, Laura ^b   Kaiser, Michael A ^a   Torielli, Lucia ^c   Casari, Giorgio ^b   Bianchi, Giuseppe ^b   Samani, Nilesh J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c Prassis Sigma Tau Research Institute   (Italy)

Author keywords

Genetic hypertension; Milan hypertensive rat; Na+ K+ATPase 1 gene; S(A) gene

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); RESTRICTION ENDONUCLEASE; MESSENGER RNA; PROTEIN; SAH PROTEIN, RAT;

ALLELE; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CHROMOSOME 1; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE LOCUS; GENE SEGREGATION; GENETIC ANALYSIS; GENOTYPE; HEREDITARY HYPERTENSION; KIDNEY; MALE; MARKER GENE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; SOUTHERN BLOTTING; SPONTANEOUSLY HYPERTENSIVE RAT; ANIMAL; BODY WEIGHT; CROSS BREEDING; DISEASE MODEL; GENETIC LINKAGE; GENETIC MARKER; GENETICS; HEART MUSCLE; HYPERTENSION; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENETIC MARKERS; GENOTYPE; HYPERTENSION; KIDNEY; LINKAGE (GENETICS); MALE; MYOCARDIUM; NA(+)-K(+)-EXCHANGING ATPASE; ORGAN SIZE; PHENOTYPE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTEINS; RATS; RNA, MESSENGER;

EID: 0031594728     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816020-00002     Document Type: Article

References (46)

1. Ward R. Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH, Brenner BM (editors). Hypertension: pathophysiology, diagnosis and management. New York: Raven Press; 1990. pp. 81-100.
2. deWardener HE. The primary role of the kidney and salt intake in the aetiology of hypertension: part I. Clin Sci 1990; 79:193-200.
3. Bianchi G, Fox U, DeFrancesco GF, Giovannetti AM, Pagetti D. Blood pressure changes produced by kidney cross-transplantation between spontaneously hypertensive rats and normotensive rats. Clin Sci 1974; 47:434-448.
4. Rettig R, Strauss H, Folberth C, Ganten B, Waldherr R, Unger T. Hypertension transmitted by kidneys from stroke-prone spontaneously hypertensive rats. Am J Physiol 1989; 257:F197-F203.
5. Rettig R, Folberth C, Strauss H, Kopf D, Waldherr R, Unger T. Role of the kidney in primary hypertension: a renal transplantation study. Am J Physiol 1990; 258:F606-F611.
6. Bianchi G, Barber BR, Torielli L, Ferrari P. The Milan Hypertensive strain of rats. In: Swales JD. Textbook of Hypertension. Oxford: Blackwell Scientific; 1994. pp. 457-460.
7. Ferrari P, Cusi D, Barber BR, Barlassina C, Vezzoli G, Duzzi L, et al. Erythrocyte membrane and renal function in relation to hypertension in rats of the Milan hypertensive strain. Clin Sci 1982; 63 (suppl 8): 61S-64S.
8. Boberg U, Persson AE. Increased tubuloglomerular feedback activity in Milan hypertensive rats. Am J Physiol 1986; 250:F967-F974.
9. Bianchi G, Baer PG. Characteristics of the Milan hypertensive strain (MHS) of rat. Clin Exp Pharmacol Physiol 1976; (suppl 3):15-20.
10. Bianchi G, Baer PG, Fox U, Duzzi L, Pagetti D, Giovanetti AM. Changes in renin, water balance and sodium balance during development of high blood pressure in genetically hypertensive rats. Circ Res 1975; 36/37 (suppl 1): 1153-1161.
11. Beck F, Bianchi G, Dorge A, Rick R, Schramm M, Thurau K. Sodium and potassium concentrations of renal cortical cells in two animal models of primary arterial hypertension. J Hypertens 1983; 1 (suppl 2): 38-39.
12. Ferrandi M, Tripodi G, Salardi S, Florio M, Modica R, Barassi P, et al. Renal Na,K-ATPase in genetic hypertension. Hypertension 1996; 28:1018-1025.
13. Samani NJ. Molecular genetics of susceptibility to the development of hypertension. Br Med Bull 1994; 50:260-271.
14. Iwai N, Inagami T. Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats. J Hypertens 1992; 10:1155-1157.
15. A gene as a candidate gene contributing to the hypertension in spontaneously hypertensive rat. Biochem Biophys Res Commun 1992; 188:64-69.
16. Lindpaintner K, Hilbert P, Ganten D, Nadal-Ginard B, Inagami T, Iwai N. Molecular genetics of the Sa gene: co-segregation with hypertension and mapping to rat chromosome 1. J Hypertens 1993; 11:83-88.
17. Harris EL, Dene H, Rapp JP. Sa gene and blood pressure co-segregation using Dahl-salt sensitive rats. Am J Hypertens 1993; 11:83-88.
18. Samani NJ, Lodwick D, Vincent M, Dubay C, Kaiser MA, Kelly MP, et al. A gene differentially expressed in the kidney of the spontaneously hypertensive rat co-segregates with increased blood pressure. J Clin Invest 1993; 92:1099-1103.
19. 2 generation from crosses between normotensive Wistar-Kyoto rats and stroke-prone spontaneously hypertensive rats. Biochem Biophys Res Commun 1993; 194:1344-1351.
20. Deng Y, Rapp JP. Co-segregation of blood pressure with angiotensin converting enzyme and natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nature Genet 1992; 1:267-272.
21. Deng AY, Dene AH, Rapp JP. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest 1994; 94:431-436.
22. Samani NJ, Gauguier D, Vincent M, Kaiser M, Bihoreau M-T, Lodwick D, et al. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13: age-related differences in effect. Hypertension 1996; 28:1118-1122.
23. Iwai N, Inagami T: Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension 1991; 17:161-169.
24. A gene in the kidney of the spontaneously hypertensive rat is localised to the proximal tubule. J Hypertens 1994; 12:1347-1352.
25. Bianchi G, Tripodi G, Casari G. Salardi S, Barber BR, Garcia R, et al. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 1994; 91:3999-4003.
26. Auffrey C, Rougeon F. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumour RNA. Eur J Biochem 1980; 107:303-314.
27. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 1989.
28. 1-subunit from rat brain. Biochemistry 1986; 25:8125-8132.
29. Hilton DA, Varend S, Pringle JH. Demonstration of coxsackie virus RNA in formalin-fixed tissue sections from childhood myocarditis from in-situ hybridisation and polymerase chain reaction. J Pathol 1993; 170:45-51.
30. Samani NJ, Brammar WJ, Swales JD. A major structural abnormality in the renin gene of the spontaneously hypertensive rat. J Hypertens 1989; 7:249-254.
31. Schlager G, Barber BR, Bianchi G. Genetic analysis of blood pressure in the Milan hypertensive strain of rat (Rattus Norvegicus). Can J Genet Cytol 1986; 28:867-970.
32. Barber BR, Ferrari P, Blanchi G. The Milan hypertensive strain: a description of the model. In: Ganten D, de Jong W (editors). Handbook of Hypertension volume 16: experimental and genetic models of hypertension. Amsterdam: Elsevier Science; 1994. pp. 316-345.
33. Iwai N, Ohmici N, Hanai K, Nakamura Y, Kinoshita M. Human SA gene locus as a candidate locus for essential hypertension. Hypertension 1994; 23:375-380.
34. Nabika T, Bonnaedeaux A, James M, Julier C, Jeunemaitre X, Corvol P, et al. Evaluation of the SA locus in human hypertension. Hypertension 1995; 25:6-13.
35. Harrap SB, Samani NJ, Lodwick D, Connor JM, Fraser R, Davies DL. et al. The SA gene: predisposition to hypertension and renal function in man. Clin Sci 1995; 88:665-670.
36. A gene variant in essential hypertensives. Am J Hypertens 1997; 10:235-242.
37. Mashimo T, Nara Y, Nabika T, Tamada T, Matsumoto C, Ikeda K, et al. A linkage analysis of basal hypertensive genes in stroke-prone spontaneously hypertensive rat (SHRSP) [abstract]. J Hypertens 1996; 14 (suppl 1):S23.
38. Ishinaga Y, Nabika T, Shimada T, Hiraoka J, Nara Y, Yamori Y. Reevaluation of the SA gene in spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Pharmacol Physiol 1997; 24:18-22.
39. Vincent M, Kaiser MA, Orea V, Lodwick D, Samani NJ. Hypertension in the spontaneously hypertensive rat and the sex chromosomes. Hypertension 1994; 23:161-166.
40. Ely DL, Turner ME. Hypertension in the spontaneously hypertensive rat is linked to the Y-chromosome. Hypertension 1990; 16:277-281.
41. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, et al. Hypertension-associated point mutations in the adducin α and β subunits affect actin cytoskeleton and ion transport. J Clin Invest 1996; 97:2815-2822.
42. Lander ES, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 1995; 11:241-247.
43. Gu L, Dene H, Deng AY, Hoebee B, Bihoreau M-T, James M, et al. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J Clin Invest 1996; 97:777-778.
44. Gaugier D, Froguel P, Parent V, Bernard C, Bihoreau M-T, Portha B, et al. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nature Genet 1996; 12:38-43.
45. Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrairad H, et al. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nature Genet 1996; 12:31-37.
46. Reaven GM, Lithell H, Landsberg L Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996; 334:374-381.