Brain injury: Prolonged induction of transcription factors

Acta Neurobiologiae Experimentalis

Volumn 60, Issue 4, 2000, Pages 515-530

  Pennypacker, Keith R ^a   Kassed, Cheryl A ^a   Eidizadeh, Shabnam ^a   O'Callaghan, James P ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

AP 1; Excitotoxicity; Fos related antigen; Ischemia; Neurotoxicity; NF B

Indexed keywords

CYTOSKELETON PROTEIN; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1;

ANTIGEN EXPRESSION; APOPTOSIS; BRAIN INJURY; BRAIN ISCHEMIA; CELL SURVIVAL; CONFERENCE PAPER; ENTORHINAL CORTEX; NERVE REGENERATION; NEUROTOXICITY; NONHUMAN; STIMULUS RESPONSE; SYNAPTOGENESIS;

ANIMALS; BRAIN; BRAIN INJURIES; GENE EXPRESSION REGULATION; HUMANS; NEURONS; TRANSCRIPTION FACTORS;

EID: 0033674442     PISSN: 00651400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (95)

1. Systemic injection of kainic acid: Gliosis in olfactory and limbic brain regions quantified with [3H]PK 11195 binding autoradiography
2. A specific inhibitor of the NFκB
3. The physiology of the NFκB transcription factor
4. 2+ accumulation
5. Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor
6. Participation of gene expression in the protection against amyloid beta-peptide toxicity by the beta-amyloid precursor protein
7. Essential role for NF-kB in preventing TNFalpha induced cell death
8. Quanitative changes in the synaptic vesicle proteins synapsin 1 and the astrocyte-specific protein glial fibrillary acidic protein are assocaiated with chemical-induced injury to the rat central nervous system
9. Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat
10. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
11. Unilateral naris closure and olfactory system development
12. Mab22C11 antibody to amyloid precursor protein recognizes a protein associated with specific astroglial cells of the rat central nervous system characterized by their capacity to support axonal outgrowth
13. Bcl-2 activates the transcription factor NFκB through degradation of the cytoplasmic inhibitor IκBα
14. The role of inducible transcription factors in apoptotic nerve cell death
15. D2 dopamine receptor antagonists induced fos and related proteins in striatal neurons
16. Molecular profile of reactive astrocytes: Implications for their role in neurologic disease
17. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
18. Regulation of nerve growth factor mRNA by interleukin-1 in rat hippocampal astrocytes is mediated by NFκB
19. Distinct effects of glutathione disulfide on the nuclear transcription factors kappaB and the activator protein-1
20. Neuronal expression of AP-1 proteins in excitoxic-neurodegenerative disorders and following nerve fiber lesions
21. Activation in vitro of NFκB by phosphorylation of its inhibitor Iκβ
22. Brain glia release factors with opposing actions on neuronal survival
23. Astrocytes are the major source of nerve growth factor upregulation following traumatic brain injury in the rat
24. Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity
25. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
26. Increased amyloid protein precursor and apolipoprotein E immunore-activity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils
27. Rapid proteolysis of Iκβ is necessary for activation of transcription factor NFκB
28. The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration
29. Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-108 cells
30. A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS
31. Molecular biology of learning: Is c-fos a new beginning?
32. Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease
33. Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons
34. Constitutive NF-kappa B activity in neurons
35. Dynamic changes in the composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death
36. Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats
37. The expression of tumor necrosis factor-alpha in the rat brain after fluid percussive head injury
38. Expression of tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) mRNA in adult human astrocytes: Comparison with adult microglia and fetal astrocytes
39. Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1
40. Temporal profile of nerve growth factor-like irnmunoreactivity after transient focal ischemia in rats
41. Purified I-kappa-beta is inactivated upon dephosphorylation
42. Janus faces of NF-kB: Neurodestruction versus neuroprotection
43. TNF-alpha, IL-lpha, and IL-1beta gene expression is not altered in response to trimethyltin-induced neuronal damage in the adult rat hippocampus
44. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
45. Prolonged increases in neurotropic activity associated with kainate-induced hippocampal synaptic reorganization
46. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo
47. H2O2 and antioxidants have opposite effects on activhtion of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
48. Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse
49. Mapping patterns of c-fos expression in the central nervous system after seizure
50. Phosphorylation and high level expression of Fra-2 in v-src transformed cells: A pathway of activation of endogenous AP-1
51. A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity
52. Isolation and characterization of fra-2, an additional member of the fos gene family
53. Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse
54. NFκB: A crucial transcription factor for glial and neuronal cell function
55. GM1 ganglioside potentiates trimethyltin-induced expression of interleukin - 1beta and nerve growth factor in reactive astrocytes in the rat hippocampus: An immunocytochemical study
56. Induction of presenilins in the rat brain after middle cerebral arterial occlusion
57. Constitutive expression of AP-1 transcription factors in the rat adrenal
58. Implications of prolonged expression of Fos-related antigens
59. Transcription factors in primary glial cultures: Changes with neuronal interactions
60. DNA binding activity of CREB transcription factor during ontogeny of the central nervous system
61. Basal expression of 35 kDa fos-related antigen in olfactory bulb
62. Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment
63. Kainate-induced changes in opioid peptide genes and AP-1 protein expression in rat hippocampus
64. Apomorphine induction of AP-1 DNA binding in the rat striatum after dopamine depletion
65. Induction of NFκB-like transcription factors in brain areas susceptible to kainate toxicity
66. Apolipoprotein E in animal model of CNS injury and in Alzheimer's disease
67. Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus
68. Induction of inhibitory factor kB alpha mRNA in the central nervous system after periphral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat
69. The amyloid beta-protein precursor promoter
70. L-DOPA activates c-fos in the striatum ipsilateral to a 6-hydroxydopamine lesion of the substantia nigra
71. Changes in expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells
72. Differential induction of Fos protein and a Fos-related antigen following acute and repeated cocaine administration
73. Stimulation of interleukin-6 secretion and gene transcription in primary astrocytes by adenosine
74. Distinct effects of thioredoxin and antioxidants on the activation of NF-kappaB and AP-1
75. NF-kappaB is activated and promotes cell death in focal cerebral ischemia
76. In vitro activation and nuclear translocation of NFκB catalyzed by cAMP-dependent protein kinase and protein kinase C
77. Continuous c-fos expression precedes programmed cell death in vivo
78. Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury
79. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure
80. Cytokine regulation of interleukin-6 gene expression m astrocytes involves activation of an NFκB-like nuclear protein
81. NF-κB activation: The IκB kinase revealed
82. Increased levels of nerve growth factor (NGF) protein and mRNA and reactive gliosis following kainic acid injection in the rat striatum
83. Increase in basic fibroblast growth factor immunoreactivity and its mRNA level in rat brain following transient forebrain ischemia
84. Induction of tumor necrosis factor-alpha
85. Long-term changes in glial fibrillary acidic protein and calcium levels in rat hippocampus after a single systemic dose of kainic acid
86. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region
87. NF-kB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
88. Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have differential effects on transcription and bind JunD, c-Fos and Fra-2
89. NF kappaB/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells
90. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival
91. Expression of AP-1 transcription factors in rat hippocampus and cerebellum after trimethyltin neurotoxicity
92. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
93. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide
94. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a κB sequence
95. Regional and differential expression of gelatinases in rat brain after systemic kainic or biculine administration