ETV6/CBFA2 fusions in childhood B-cell precursor acute lymphoblastic leukemia with myeloid markers

Diagnostic Molecular Pathology

Volumn 9, Issue 4, 2000, Pages 184-189

  Rafi, Syed K ^a   El Gebaly, Howeida ^a   Qumsiyeh, Mazin B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

B cell precursor acute lymphoblastic leukemia; Childhood leukemia; Translocation t(12; 21)

Indexed keywords

CD33 ANTIGEN; LYMPHOCYTE SURFACE MARKER; MICROSOMAL AMINOPEPTIDASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; B CELL LEUKEMIA; BONE MARROW CELL; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 21; CHROMOSOME TRANSLOCATION 12; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; GENE LOCUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPHENOTYPING; ISOCHROMOSOME; MALE; NUMERICAL CHROMOSOME ABERRATION; PRIORITY JOURNAL; STRUCTURAL CHROMOSOME ABERRATION;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; LEUKEMIA, B-CELL, ACUTE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; MYELOID PROGENITOR CELLS; ONCOGENE PROTEINS, FUSION; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 0033659492     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200012000-00002     Document Type: Article

References (39)

1. Frequent deletion of chromosome 12p12.3 in children with acute lymphoblastic leukaemia
2. The majority of myeloid-antigen-positive (My+) childhood B-cell precursor acute lymphoblastic leukemias express TEL-AML1 fusion transcripts
3. Chromosomal abnormalities of 12 n hematopoietic malignancies
4. Incidence and clinical relevance of TEL/AML1 fusion genes on children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials
5. Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: A Pediatric Oncology Group study
6. ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia
7. TEL-AML fusion RNA as a new traget to detect minimal residual disease in pediatric B-Cell Precursor Acute Lymphoblastic leukemia
8. Correlation between the ETV6/CBFA2 (TEL/AML1) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia
9. Fusion of the TEL gene on 12 p13 to AML1 gene on 21q22 in acute lymphoblastic leukemia
10. Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases
11. The der(21)t(12;21) chromosome is always formed in a 12;21 translocation associated with childhood acute lymphoblastic leukaemia
12. The AML1/Evi-1 fusion protein in the t(3;21) translocation exhibits transforming activity on rat1 fibroblasts with dependence on the evi-1 sequence
13. High incidence of TEL/AML1 fusion resulting from crypyic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan
14. Lack of TEL/AML1 fusion in pediatric AML: Further evidence for lineage specificity of TEL/AML1
15. TEL/AML1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia
16. Identification of AML-1 and the (8;21) translocation protien (AML1/ETO) as sequence-specific DNA- binding protein: The runt homology domin is required for DNA binding and binding protein -protien interaction
17. FISHing among myeloproliferative disorders
18. Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells
19. The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER-1
20. CBFA2, the target of multiple chromosomal translocations in human leukemia, is essential for normal liver hematopoiesis
21. Childhood Leukemias
22. Chromosomal translocations in human cancer
23. Current status of cytogenetic research in childhood acute lymphoblastic leukemias
24. Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia
25. The 12;21 translocation involving TEL and deletion of the other TEL allele: Two frequently associated alterations found in childhood acute lymphoblastic leukemia
26. Cytogenetic abnormalities associated with the t(12;21): A collaborative study of 169 children with t(12;21)-positive acute lymphoblastic leukemia
27. Deletion of the short arm of chromosome 12 is a secondary event in acute lymphoblastic leukemia with the t(12;21)
28. t(12;21): New translocation in acute leukemia
29. High frequency of t(12;21) in childhood B lineage acute lymphoblastic leukemia
30. TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia
31. Hematopoietic differentiation antigens that are membrane associated enzymes: Cuting is the key
32. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patient with an excellent prognosis
33. Detection of t(12;21) in Childhood Acute Lymphoblastic Leukemia by Fluorescence In Situ Hybridization
34. Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia
35. Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer: Evidence for a new tumor suppressor gene on the short arm of chromosome 12
36. Four-color flow cytometry
37. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
38. Leukemias and Lymphomas in Childhood
39. Bialleleic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case