Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer: Evidence for a new tumor suppressor gene on the short arm of chromosome 12

Cancer Research

Volumn 56, Issue 4, 1996, Pages 738-740

  Takeuchi, Seisho ^a   Mori, Naoki ^a   Koike, Michiaki ^a   Slater, James ^a   Park, Susan ^a   Miller, Carl W ^a   Miyoshi, Isao ^b   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CHROMOSOME 12P; CHROMOSOME LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN TISSUE; LARGE CELL CARCINOMA; LUNG NON SMALL CELL CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOUTHERN BLOTTING; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE PROTEINS; CHROMOSOME DELETION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 12; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA; DNA, NEOPLASM; EXONS; GENES, TUMOR SUPPRESSOR; GENETIC MARKERS; HUMANS; LUNG; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REFERENCE VALUES; TUMOR SUPPRESSOR PROTEINS;

EID: 0030039909     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Chiba, I., Takahashi, T., Nau, M., D'Amico, D., Curiel, D., Mitsudomi, T., Buchhagen, D., Carbone, D., Piantadosi, S., Koga, H., Reissman, P., Slamon, D., Holmes, E. C , and Minna, J. D. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene, 5: 1603-1611, 1990.
2. Harbour, J W , Lai, S-L., Whang-Peng, J., Gazdar, A. F., Minna, J D , and Kaye, F. J. Abnormalities in structures and expression of the human retinoblastoma gene in SCLC Science (Washington DC), 241: 353-357, 1988.
3. de Vos, S., Miller, C. W , Takeuchi, S., Gombart, A. F., Cho, S. K., and Koeffler, H P Alterations of CDKN2 (p16) in non-small cell lung cancer. Genes Chromosomes & Cancer, 14: 164-170, 1995.
4. INK4B/ MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res , 55: 1448-1451, 1995
5. Whang-Peng, J., Knutsen, T., Gazdar, A., Steinberg, S. M., Oie, H., Linnoila, I., Mulshine, J., Nau, M., and Minna, J. D. Nonrandom structural and numerical chromosome changes in non-small-cell lung cancer. Genes Chromosomes & Cancer, 3: 168-188, 1991.
6. Johansson, M., Jin, Y., Mandahl, N., Hambraeus, G , Johansson, L., Mitelman, F., and Heim, S. Cytogenetic analysis of short-term cultured squamous cell carcinoma of the lung. Cancer Genet. Cytogenet , 81: 46-55, 1995.
7. Tsuchiya, E., Nakamura, Y., Weng, S-Y , Nakagawa, K., Tsuchiya, S., Sugano, H., and Kitagawa, T. Allelotype of non-small cell lung carcinoma, comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma. Cancer Res , 52: 2478-2481, 1992.
8. Sato, S., Nakamura, Y., and Tsuchiya, E Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung. Cancer Res., 54: 5652-5655, 1994.
9. Weissenbach, J., Gyapay, G., Dib, C., Vignal, A., Morissette, J., Millasseau, P., Vaysseix, G., and Lathrop, M. A second-generation linkage map of the human genome. Nature (Lond.), 359: 794-801, 1992.
10. Gyapay, G , Morissette, J , Vignal, A , Dib, C., Fizames, C., Millasseau, P., Marc, S., Bernardi, G., Lathrop, M., and Weissenbach, J. The 1993-94 Généthon human genetic linkage map Nat. Genet., 7: 246-339, 1994.
11. Pearson, P L., Matheson, N. W., Flescher, D. C., and Robbins, R J. The GDB human genome data base anno 1992. Nucleic Acids Res., 20 (Suppl.): 2201-2204, 1992
12. Stegmaier, K., Pendse, S., Barker, G. F., Bray-Ward, P., Ward, D. C., Montgomery, K. T., Krauter, K S., Reynolds, C., Sklar, J., Donnelly, M., Bohlander, S. K., Rowley, J. D., Sallan, S. E., Gilliland, D. G., and Golub, T. R. Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood, 86 38-44, 1995.
13. KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals Cell, 78: 59-66, 1994.
14. Toyoshima, H., and Hunter, T. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21 Cell, 78: 67-74, 1994
15. Kip1, to regions involved in human cancer. Cancer Res , 55: 1199-1205, 1995
16. kip1 gene to 12p13 and its analysis in leukemia. Cancer Res., 55: 1206-1210, 1995.
17. Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors Cancer Res., 55. 1211-1214, 1995.
18. Kawamata, N , Morosetti, R., Miller, C. W., Park, D , Spirin, K. S., Nakamaki, T., Takeuchi, S., Hatta, Y., Simpson, J., Wilczynski, S., Lee, Y Y., Bartram, C. R., and Koeffler, H. P. Molecular analysis of the cyclin-dependent kinase inhibitor p27/kip1 gene in human malignancies. Cancer Res , 55: 2266-2269, 1995.
19. Fong, K. M., Kida, Y., Zimmerman, P. V., Ikenaga, M., and Smith, P. J. Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer. Cancer Res , 55: 4268-4272, 1995.
20. Takeuchi, S., Bartram, C. R., Miller, C. W , Reiter, A., Seriu, T., Zimmermann, M., Schrappe, M., Mori, N , Slater, J., Miyoshi, I., and Koeffler, H. P Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1 Blood, in press, 1996.