Chromosome abnormalities of the short arm of chromosome 12 in hematopoietic malignancies: A report including three novel translocations involving the TEL/ETV6 gene

Leukemia

Volumn 11, Issue 9, 1997, Pages 1400-1403

  Berger, R ^a   Le Coniat, M ^a   Lacronique, V ^a   Daniel, M T ^b   Lessard, M ^c   Berthou, C ^c   Marynen, P ^d   Bernard, O ^a  

^a INSERM   (France)

^b Laboratoire Central d'Hematologie   (France)

^c Lab de Cytogénétique   (France)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

12p abnormalities; Chromosomes; ETV6; Leukemia

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CENTROMERE; CHILDHOOD LEUKEMIA; CHROMOSOME 12; CHROMOSOME 12P; CHROMOSOME ABERRATION; CHROMOSOME BANDING PATTERN; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; GENE LOCATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; KARYOTYPE; LEUKEMIA; LEUKEMIA CELL; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

EID: 0030853615     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400785     Document Type: Article

References (13)

1. Mitelman F. Catalog of Chromosome Aberrations in Cancer 5th edn. Wiley-Liss: New York, 1994.
2. Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994; 77: 307-316.
3. Romana SP, LeConiat M, Berger R.t(12;21): a new recurrent translocation in acute lymphoblastic leukemia. Genes Chromos Cancer 1994; 9: 186-191.
4. Raynaud S, Cavé H, Baens M, Bastard C, Cacheux V, Grosgeorge J, Guidal-Giroux C, Guo C, Vilmer E, Marynen P, Granchamp B. The t(12;21) translocation involving TEL and deletion of the other allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood 1996; 87: 2891-2899.
5. Romana SP, Le Coniat M, Poirel H, Marynen P, Bernard OA, Berger R. Deletion of the short arm of chromosome 12 is a secondary event in acute lymphoblastic leukemia. Leukemia 1996; 10: 167-170.
6. Bernard OA, Romana SP, Poirel H, Berger R. Molecular cytogenetics of t(12;21)(p13;q22). Leuk Lymphoma 1996; 23: 459-465.
7. Peeters P, Wlodarska I, Baens M, Criel A, Selleslag D, Hagemeijer A, Van den Berghe H, Marynen P. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Cancer Res 1997; 57: 564-567.
8. Baens M, Peeters P. Guo C, Aerssens J, Marynen P. Genomic organization of TEL: the human ETS-variant gene 6. Genome Res 1996; 6: 404-413.
9. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 1995; 92: 4917-4921.
10. Aerssens J, Guo C, Vermeesch J, Baens M, Browne D, Litt M, Van Den Berghe H, Marynen P. A physical map of the region spanning the chromosome 12 translocation breakpoint in a mesothelioma with a t(X;12)(q22;p13). Cytogenet Cell Genet 1995; 71: 268-275.
11. Marynen P, Kucherlapati R. Report of the Third International Workshop on Human Chromosome 12 Mapping 1995. Cytogenet Cell Genet 1996; 73: 1-24.
12. Kobayashi H, Montgomery KT, Bohlander SK, Adra CN, Lim BL, Kucherlapati RS, Donis-Keller H, Holt MS, Le Beau MM, Rowley JD. Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood 1994; 84: 3473-3482.
13. Kobayashi H, Rowley JD. Identification of cytogenetically undetected 12p13 translocations and associated deletions with fluorescence in situ hybridization. Genes Chromos Cancer 1995; 12: 66-69.