The der(21)t(12;21) chromosome is always formed in a 12;21 translocation associated with childhood acute lymphoblastic leukaemia

British Journal of Haematology

Volumn 94, Issue 1, 1996, Pages 105-111

  Kobayashi, Hirofumi ^a   Satake, Noriko ^a   Maseki, Nobuo ^a   Sakashita, Akiko ^a   Kaneko, Yasuhiko ^a  

^a Saitama Cancer Centre Hospital   (Japan)

Author keywords

ALL; AML1; Chromosomal aberration; FISH; TEL

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 21; CHROMOSOME TRANSLOCATION 12; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0030055379     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1762.x     Document Type: Article

References (22)

1. Beverloo, H.B., LeConiat, M., Wijsman, J., Lillington, D.M., Bernard, O., de Klein, A., van Wering, E., Welborn, J., Young, B.D., Hagemeijer, A. & Berger, R. (1995) Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis. Cancer Research, 55, 4220-4224.
2. Bohlander, S.K., Espinosa, R., III, Fernald, A.A., Rowley, J.D., LeBeau. M.M. & Diaz, M.O. (1994) Sequence-independent amplification and labeling of yeast artificial chromosomes for fluorescence in situ hybridization. Cytogenetics and Cell Genetics, 65, 108-110.
3. Buijs, A., Sherr, S., van Baar, S., van Bezouw, S., van der Plas, D., van Kessel, A.G., Riegman, P., Deprez, R.L., Zwarthoff, E., Hagemeijer, A. & Grosveld, G. (1995) Translocation (12;22)-(p13;q11) in myeloproliferative disorders results in fusion of ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene, 10, 1511-1519.
4. Golub, T.R., Baker, F.G., Bohlander, S.K., Hiebert, S.W., Ward, D.C., Bray-Ward, P., Morgan, E., Raimondi, S.C., Rowley, J.D. & Gilliand, D.G. (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 92, 4917-4921.
5. Golub, T.R., Baker, F.G., Bohlander, S.K., Stegmajer, K., Bray-Ward, P., Ward, D.C., Sato, Y., Suto, Y., Rowley, J.D. & Gilliland, D.G. (1994a) Evidence implicating the TEL gene at 12p13 in multiple mechanisms of leukemogenesis. Blood, 84, (Abstract Supplement). 229a.
6. Golub, T.R., Barker, G.F., Lovett, M. & Gilliliand, D.G. (1994b) Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation, Cell, 77, 1-10.
7. ISCN (1991) Guideline for Cancer Cytogenetics. Supplement to an International System for Human Cytogenetic Nomenclature (ed. by F. Mitelman), Karger, Basel.
8. Kobayashi, H., Espinosa, R., III, Thirman, M.J., Davis, E., Diaz, M.O., Le Beau, M.M. & Rowley, J.D. (1993) Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization. Blood, 81, 3027-3033.
9. Kobayashi, H., Maseki, N., Homma, C., Sakurai, M. & Kaneko, Y. (1994a) Clinical significance of chromosomal abnormalities in childhood acute lymphoblastic leukemia in Japan. Leukemia, 8, 1944-1950.
10. Kobayashi, H., Montgomery, K.T., Bohlander, S.K., Adra, A.N., Lim, B.L., Kucherlapati, R.S., Donis-Keller, H., Holt, M.S., Le Beau, M.M. & Rowley, J.D. (1994b) Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases. Blood, 84, 3473-3482.
11. Kobayashi, H. & Rowley, J.D. (1995) Identification of undetected 12p13 translocations and associated deletions with fluorescence in situ hybridization. Genes. Chromosomes and Cancer, 12, 66-69.
12. Mitelman, F. (1994) Catalog of Chromosome Aberrations in Cancer. Alan R. Liss, New York.
13. Miyoshi, H., Ohira, M., Shimizu, K., Mitant, K., Hirai, H., Imai, T., Yokoyama, K., Soeda, E. & Ohki, M. (1995) Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucleic Acids Research, 23, 2762-2769.
14. Miyoshi, H., Shimizu, K., Kozu, T., Maseki, N., Kaneko, Y. & Ohki, M. (1991) t(8:21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene. AML1. Proceedings of the National Academy of Sciences of the United States of America, 88, 10431-10434.
15. Raimondi, S.C., Williams, D.L., Callihan, T., Peiper, S., Rivera, G.K. & Murphy, S.B. (1986) Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia. Blood, 68, 69-75.
16. Romana, S.P., LeConiat, M. & Berger, R. (1994) t(12;21): a new recurrent translocation in acute lymphoblastic leukemia. Genes, Chromosomes and Cancer, 9, 186-191.
17. Romana, S.P., Mauchauffé, M., LeConiat, M., Chumakov, I., LePaslier, D., Berger, R. & Bernard, O.A. (1995a) The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood, 85, 3662-3670.
18. Romana, S.P., Poirel, H., LeConiat, M., Flexor, M.-A., Mauchauffé, M., Jonveaux, P., Macintyre, E.A., Berger, R. & Bernard, O.A. (1995b) High frequency of t(12:21) in childhood B lineage acute lymphoblastic leukemia. Blood, 86, 4263-4269.
19. Rowley, J.D., Diaz, M.O., Espinosa, R., III, Patel, Y.D., Van Melle, E., Ziemin, S., Taillon-Miller, P., Lichter, P., Evans, G.A., Kersey, J.H., Ward, D.C., Domer, P.H. & Le Beau, M.M. (1990) Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome. Proceedings of the National Academy of Sciences of the United States of America, 87, 9358-9362.
20. Sanger, F., Nicklen, S. & Coulson, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 74, 5463-5467.
21. Satake, N., Maseki, N., Kozu, T., Sakashita, A., Kobayashi, H., Sakurai, M., Ohki, M. & Kaneko, Y. (1995) Disappearance of AML1-MTG8 (ETO) fusion transcript in acute myeloid leukaemia patients with t(8;21) in long-term remission. British Journal of Haematology, 91, 892-898.
22. Shurtleff, S.A., Buijs, A., Behm, F.G., Rubnitz, J.E., Raimondi, S.C., Hancock, M.L., Chan, G.C.-F., Pui, C.-H., Grosveld, G. & Downing, J.R. (1995) TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia, 9, 1985-1989.