Inhibition of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline

Carcinogenesis

Volumn 17, Issue 8, 1996, Pages 1719-1728

  Robertson, Fredika M ^a   Ross, Mary S ^a   Tober, Kathleen L ^a   Long, Brooks W ^a   Oberyszyn, Tatiana M ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DIMETHYLBENZ[A]ANTHRACENE; INTERLEUKIN 1ALPHA; MYELOPEROXIDASE; PENTOXIFYLLINE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL INFILTRATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME REGULATION; EPIDERMIS HYPERPLASIA; FEMALE; GENE REPRESSION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEUTROPHIL; NONHUMAN; PAPILLOMA; PRIORITY JOURNAL; SKIN CARCINOGENESIS; SKIN INFLAMMATION; SKINFOLD;

EID: 0029784572     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.8.1719     Document Type: Article

References (80)

1. Klein-Szanto, A.J.P., Conti, C.J., Aldaz, C.M., Clapp, N., Nesnow, S. and Slaga, T.J. (1986) Effects of chronic topical application of 12-O-tetradecanoylphorbol-13-acetate on the skin and internal organs of Sencar mice. Environ. Hlth Perspect., 68, 75-80.
2. Lewis, J.G. and Adams, D.O. (1987) Early inflammatory changes in the skin of Sencar mice and C57BL/6 mice following exposure to 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis, 8, 889-898.
3. Frenkel, K. (1992) Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol. Ther., 53, 127-166.
4. Gahring, L.C., Buckley, A. and Daynes, R.A. (1985) Presence of epidermal-derived thymocyte activating faclor/IL-1 in normal stratum corneum. J. Clin. Invest., 76, 1585-1591.
5. Hauser, C., Saurat, J.-H., Schmitt, A., Jaunin, F. and Dayer, J.-M. (1986) Interleukin-1 is present in normal human epidermis. J. Immunol., 136, 3317-3323.
6. Camp, R., Finchman, N., Ross, J., Bird, C. and Gearing, A. (1990) Potent inflammatory properties in human skin of interleukin-1 alpha-like material isolated from normal skin. J. Invest. Dermatol., 94, 735-741.
7. Granstein, R.D. and Sauder, D.N. (1987) Whole body exposure to ultraviolet radiation results in increased serum interleukin-1 activity in humans. Lymphokine Res., 6, 187-193.
8. Oberyszyn, T.M., Sauder, D.N., Long, B.W. and Robertson, F.M. (1995) Interleukin-1α as a biomarker for the epidermal response to mononuclear cell-derived cytokines and inflammatory stimuli. In Vitro Toxicol., 8, 435-449.
9. Robertson, F.M., Pellegrini, A.E. Ross, M.S., Oberyszyn, A.S., Boros, L.G., Bijur, G.N., Sabourin, C.L.K. and Oberyszyn, T.M. (1995) Interleukin-1α gene expression during wound healing. Wound Repair Regenerat., 3, 473-484.
10. Oberyszyn, T.M., Sabourin, C.L.K., Bijur, G.N., Boros, L.G. and Robertson, F.M. (1993) Interleukin-1α gene expression and localization of interleukin-1α protein during tumor promotion. Mol. Carcinogen., 7, 238-248.
11. Robertson, F.M., Bijur, G.N., Oberyszyn, A.S., Nill, M.R., Boros, L.G., Spencer, W.J., Sabourin, C.L.K. and Oberyszyn, T.M. (1994) Interleukin-1α in murine multistage skin carcinogenesis. In Muhktar, H. (ed.), Skin Cancer: Mechanisms and Human Relevance. CRC Press, Boca Raton, FL, pp. 251-272.
12. Sayers, T.J., Wiltrout, T., Bull, C.A., Denn, A.C., Pilaro, A.M. and Lokesh, B. (1988) Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse:prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor. J. Immunol., 141, 1670-1677.
13. Mason, M.J. and Van Epps, D.E. (1989) In vivo neutrophil emigration in response to interleukin-1 and tumor necrosis factor. J. Leukemia Biol., 45, 62-68.
14. Matsushima, K. and Oppenheim, J.J. (1989) Interleukin-8 and MCAF: novel inflammatory cytokines inducible by IL-1 and TNF. Cytokine, 1, 2-13.
15. Le, J. and Vilcek, J. (1987) Biology of disease. Tumor necrosis factor and interleukin-1: cytokines with multiple overlapping biological activities. Lab. Invest., 56, 234-248.
16. Old, L.J. (1985) Tumor necrosis factor. Science, 230, 630-632.
17. Nelson, S., Chidiac, C., Bagby, G. and Summer, W.R. (1990) Endotoxin-induced suppression of lung host defenses. J. Med., 21, 85-103.
18. Han, J., Brown, T. and Beutler, B. (1990) Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J. Exp. Med., 171, 465-475.
19. Tsujimoto, M., Yokota, S., Vilcek, J. and Weissmann, G. (1986) Tumor necrosis factor provokes superoxide anion generation from neutrophils. Biochem. Biophys. Res. Commun., 137, 1094-1100.
20. Larrick, J.W., Graham, D., Toy, K., Lin, L.S., Senyk, G. and Fendly, B.M. (1987) Recombinant tumor necrosis factor causes activation of human granulocytes. Blood, 69, 640-644.
21. Shalaby, M.R., Palladino, M.A., Jr, Hirabayashi, S.E., Eessalu, T.E., Lewis, G.D., Shepard, H.M. and Aggarwal, B.B. (1987) Receptor binding and activation of polymorphonuclear neutrophils by tumor necrosis factor-alpha. J. Leukemia Biol., 41, 196-204.
22. Bajaj, M.S., Kew, R.R., Webster, R.O. and Hyers, T.M. (1992) Priming of human neutrophil functions by tumor necrosis factor: enhancement of superoxide anion generation, degranulation, and chemotaxis to chemoattractants C5a and F-Met-Leu-Phe. Inflammation, 16, 241-250.
23. Berkow, R.L., Wang, D., Larrick, J.W., Dodson, R.W. and Howard, T.H. (1987) Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor. J. Immunol., 139, 3783-3791.
24. Piguet, P.F., Grau, G.E., Haiser, C. and Vassalli, P. (1991) Tumor necrosis factor is a critical factor in hapten induced irritant and contact hypersensitivity reactions. J. Exp. Med., 173, 673-679.
25. Kock, A., Schwarz, T., Kirnbauer, R., Urbanski, A., Perry, P., Ansel, J.C. and Luger, T.A. (1990) Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J. Exp. Med., 172, 1609-1614.
26. Detmar, M. and Orfanos, C.E. (1990) Tumor necrosis factor-alpha inhibits cell proliferation and induces class II antigens and cell adhesion molecules in cultured normal human keratinocytes in vitro. Arch. Dermatol. Res., 282, 238-245.
27. Pillai, S., Bikle, D.D., Eessalu, T.E., Aggarwal, B.B. and Elias, P.M. (1989) Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J. Clin. Invest., 83, 816-821.
28. Oberyszyn, T.M., Bijur, G.N., Oberyszyn, A.S., Sabourin, C.L.K. and Robertson, F.M. (1993) Tumor necrosis factor (TNF-α) downregulates the cutaneous response to 12-O-tetradecanoylphorbol-13-acetate (TPA) in SENCAR mice. Proc. Am. Ass. Cancer. Res., 34, 466.
29. Fujiki, H., Suganama, M., Komori, A., Yatsunami, J., Okabe, S., Ohta, T. and Sueoka, E. (1994) A new tumor promotion pathway and its inhibitors. Cancer Detect. Prevent., 18, 1-7.
30. Fujiki, H., and Suganuma, M. (1994) Tumor necrosis factor-alpha, a new tumor promoter, engendered by biochemical studies of okadaic acid. J. Biochem., 115, 1-5.
31. Komori, A., Yatsunami, J., Suganuma, M., Okabe, S., Abe, S., Sakai, A., Sasaki, K. and Fujiki, H. (1993) Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation. Cancer Res., 53, 1982-1985.
32. Conney, A.H., Wang, Z.Y., Huang, M.T., Ho, C.T. and Yang, C.S. (1992) Inhibitory effect of green tea on tumorigenesis by chemicals and ultraviolet light. Preventive Med., 21, 361-369.
33. Katiyar, S.K., Agarwal, R. and Mukhtar, H. (1993) Protection against malignant conversion of chemically induced benign skin papillomas to squamous cell carcinomas in SENCAR mice by a polyphenolic fraction isolated from green tea. Cancer Res., 53, 5409-5412.
34. Wei, H. and Frenkel, K. (1992) Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion. Cancer Res., 52, 2298-2303.
35. Frenkel, K., Wei, H., Bhimani, R., Ye, J., Zadunaisky, J.A., Huang, M.T., Ferraro, T., Conney, A.H. and Grunberger, D. (1993) Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester. Cancer Res., 53, 1255-1261.
36. Spittell, J.A. (1985) Pentoxifylline and intermittent claudication. Annls Internal Med., 102, 126-127.
37. Samlaska, C.P. and Winfield, E.A. (1994) Pentoxifylline. J. Am. Acad. Dermatol., 30, 603-621.
38. Currie, M.S., Simel, D.L., Christenson, R.H., Holmes, C., Crawford, J., Cohen, H.J. and Rao, K.M. (1991) Anti-inflammatory effects of pentoxifylline in claudication. Am. J. Med. Sci., 301, 85-90.
39. Doherty, G.M., Jensen, J.C., Alexander, H.R., Buresh, C.M. and Norton, J.A. (1991) Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery, 110, 192-198.
40. Strieter, R.M., Remick, D.G., Ward, P.A., Spengler, R.N., Lynch, J.P., Larrick, J. and Kunkel, S.L. (1988) Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem. Biophys. Res. Commun., 155, 1230-1236.
41. Han, J., Thompson, B. and Beutler, B. (1990) Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signalling pathway. J. Exp. Med., 172, 391-394.
42. Zabel, P., Schade, F.U. and Schlaak, M. (1993) Inhibition of endogenous TNF formation by pentoxifylline. Immunobiology, 187, 447-463.
43. Mandell, G.L. and Novick, W.J., Jr (eds) (1988) Proceedings of a Symposium, Penotoxifyline and Leukocyte Function. Hoechst-Roussell Pharmaceuticals Inc., Somerville, NJ.
44. Bessler, H.R., Gilgal, M., Djaldetti, M. and Zahavi, I. (1986) Effect of pentoxifylline on the phagocytic activity, cAMP levels and superoxide anion production by monocytes and polymorphonuclear cells. J. Leukemia Biol., 40, 747-754.
45. Crouch, S.P.M. and Fletcher, J. (1992) Effect of ingested pentoxifylline on neutrophil superoxide anion production. Infect. Immun., 60, 4504-4509.
46. Freitas, J.P. and Filipe, P.M. (1995) Pentoxifylline. A hydroxyl radical scavenger. Biol. Trace Element Res., 47, 307-311.
47. Lehr, H.A., Krombach, F., Munzing, S., Bodlaj, R., Glaubitt, S.I., Seiffge, D., Hubner, C., von Andrian, U.H. and Messmer, K. (1995) In vitro effects of oxidized low density lipoprotein on CD11b/CD18 and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation. Am. J. Pathol., 146, 218-227.
48. Trush, M.A., Egner, P.A. and Kensler, T.W. (1994) Myeloperoxidase as a biomarker of skin irritation and inflammation. Fd Chem Toxicol., 32, 143-147.
49. Hestdal, K., Ruscetti, F.W., Ihle, J.N., Jacobson, S.E.W., Dubois, C.M., Kopp, W.C., Longo, D.L. and Keller, J.R. (1991) Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J. Immunol., 147, 22-28.
50. Spangrude, G.J., Helfeld, S. and Weissman, I.L. (1988) Purification and characterization of mouse hematopoietic stem cells. Science, 241, 58-62.
51. Kurki, P., Vanderlaan, M., Dolbeare, F. Gray, J. and Tan, E.M. (1986) Expression of proliferating cell specific antigen (PCNA/cyclin) during the cell cycle. Exp. Cell Res., 166, 209-219.
52. Lee, J.S., Lippman, S.M., Hong, W.K., Ro, J.Y., Kim, S.Y., Lotan, R. and Hittelman, W.N. (1992) Determination of biomarkers for intermediate end points in chemoprevention trials. Cancer Res., 52, 2707s-2710s.
53. Robbins, B.A., dela Vega, D., Ogata, K., Tan, E.M. and Nakamura, R.M. (1987) Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies. Arch. Pathol. Lab. Med., 111, 841-845.
54. Robertson, F.M., Bijur, G.N., Oberyszyn, A.S., Pellegrini, A.E., Boros, L.G. and Oberyszyn, T.M. (1994) Granulocyte-macrophage colony stimulating factor gene expression and function during tumor promotion. Carcinogenesis, 15, 1017-1029.
55. Nill, M.R., Oberyszyn, T.M., Ross, M.S., Oberyszyn, A.S. and Robertson, F.M. (1995) Temporal sequence of pulmonary cytokine gene expression in response to endotoxin in C3H/HeN endotoxin sensitive and C3H/HeJ endotoxin resistant mice. J. Leukemia Biol., 58, 563-574.
56. Murphy, E., Hieny, S., Sher, A. and O'Garra, A. (1993) Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Shistosoma mansoni infected mice. J. Immunol. Methods, 162, 211-223.
57. Dicesare, J., Grossman, B., Katz, E., Picozza, E., Ragusa, R. and Woudenberg, T. (1993) A high sensitivity electrochemiluminescence-based detection system for automated PCR product quantitation. Biotechniques, 15, 152-157.
58. Lee, W.Y., Fischer, S.M., Butler, A.P. and Locknislar, M.F. (1993) Modulation of interleukin-1α mRNA expression in mouse epidermis by tumor promoters and antagonists. Mol. Carcinogen., 7, 26-35.
59. Lee W.Y., Lockniskar, M.F. and Fischer, S.M. (1994) Interleukin-1 alpha mediates phorbol ester-induced inflammation and epidermal hyperplasia. FASEB J., 8, 1081-1087.
60. Katiyar, S.K., Rupp, C.O., Korman, N.J., Agarwal, R. and Mukhtar, H. (1995) Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols. J. Invest. Dermatol., 105, 394-398.
61. Hewett, J.A., Jean, P.A., Kunkel, S.L. and Roth, R.A. (1993) Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury. Am. J. Physiol., 265, G1011-G1015.
62. van Leenen, D., van der Poll., T., Levi, M., ten Gate, H., van Deventer, S.J., Hack, C.E., Aarden, L.A. and ten Cate, J.W. (1993) Pentoxifylline attentuates neutrophil activation in experimental endotoxemia in chimpanzees. J. Immunol., 151, 2318-2325.
63. Rott, O., Cash, E. and Fleischer, B. (1993) Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1- but not type 2-associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats. Eur. J. Immunol., 23, 1745-1751.
64. Alegre, M.L., Gastaldello, K., Abramowicz, D. et al. (1991) Evidence that pentoxifylline reduces anti-Cd3 monoclonal antibody induced cytokine release syndrome. Transplantation, 52, 674-679.
65. Schwartz, A., Krone, C., Trautinger, F., Aragane, Y., Neuner, P., Luger, T.A. and Schwarz, T. (1993) Pentoxifylline suppresses irritant and contact hypersensitivity reactions. J. Invest. Dermatol., 101, 549-552.
66. Sirak, A.A., Beavis, A.J. and Robertson, F.M. (1991) Enhanced hydroperoxide production by peripheral blood leukocytes following exposure of murine epidermis to 12-O-tetradecanoylpnorbol-13-acetate. Carcinogenesis, 12, 91-95.
67. Frenkel, K., Wei, L. and Wei, H. (1995) 7,12-Dimethylbenz[a]anthracene induces oxidative DNA modification in vivo. Free Radical Biol. Med., 19, 373-380.
68. Rice, G.C., Brown, P.A., Neson, R.J., Bianco, J.A., Singer, J.W. and Bursten, S. (1994) Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc. Natl Acad. Sci. USA. 91, 3857-3861.
69. Rice, G.C., Rosen, J., Weeks, R., Michnick, J., Bursten, S., Bianco, J.A. and Singer, J.W. (1994) CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo. Shock, 1, 254-266.
70. Bursten, S., Weeks, R., West, J., Le, T., Wilson, T., Porubek, D., Bianco, J.A., Singer, J.W. and Rice, G.C. (1994) Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta. Circ. Shock, 44, 14-29.
71. Abraham, E., Bursten, S., Shenkar, R. et al. (1995) Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice. J. Exp. Med., 181, 569-575.
72. Knauss, T.C., Jaffer, F.E. and Abboud, H.E. (1990) Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet derived growth factor mRNAs in cultured mesangial cells. J. Biol. Chem., 265, 14457-14463.
73. Bucckino, S.B., Wilson, P.B. and Exton, J.H. (1991) Phosphatidate-dependent protein phosphorylation. Proc. Natl Acad. Sci. USA, 88, 6210-6213.
74. Bursten, S.L. and Harris, W.E. (1994) Interleukin-1 stimulates phosphatidic acid-mediated phospholipase D activity in human mesangial cells. Am. J. Physiol., 266, C1093-C1104.
75. Carnero, A., Cuadrado, A., del Peso, L. and Lacal, J.C. (1994) Activation of type D phospholipase D by serum stimulation and ras-induced transformation in NIH3T3 cells. Oncogene, 9, 1387-1395.
76. Tsai, M.-H., Yu, C.-L. and Stacey, D.W. (1990) A cytoplasmic protein inhibits the GTPase activity of H-ras in a phospholipid dependent manner. Science, 250, 282-285.
77. Moolenaar, W.H., Kruijer, W., Tilly, B.C., Verlaan, I., Bierman, A.J. and de Laat, S.W. (1986) Growth factor-like action of phosphatidic acid. Nature, 323, 171-173.
78. Zhou, D., Luini, W., Bernasconi, S., Diomede, L., Salmona, M., Mantovani, A. and Sozzani, S. (1995) Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes. J. Biol. Chem., 270, 25549-25556.
79. Yasui, K., Komiyama, A., Molski, T.F. and Sha'afi, R.I. (1994) Pentoxifylline and CD14 antibody additively inhibit priming of polymorphonuclear leukocytes for enhanced release of superoxide by lipopolysaccharide: possible mechanism of these actions. Infect. Immun., 62, 922-927.
80. Angel, J., Audubert, F., Bismuth, G. and Fournier, C. (1994) IL-1 beta amplifies bradykinin-induced prostaglandin E2 production via a phospholipase D-linked mechanism. J. Immunol., 152, 5032-5040.