The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27

Journal of Virology

Volumn 71, Issue 6, 1997, Pages 4614-4625

  Samaniego, Lorna A ^a   Wu, Naxin ^a   DeLuca, Neal A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GENE PRODUCT; MESSENGER RNA; REGULATOR PROTEIN; THYMIDINE KINASE; VIRUS PROTEIN;

ARTICLE; CELL SURVIVAL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HERPES SIMPLEX VIRUS; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; VIRUS GENOME; VIRUS MUTANT;

EID: 0030958819     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.6.4614-4625.1997     Document Type: Article

References (100)

1. Ace, C. I., T. A. McKee, J. M. Ryan, J. M. Cameron, and C. M. Preston. 1989. Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression. J. Virol. 63:2260-2269.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1991. Current protocols in molecular biology. John Wiley & Sons, New York, N.Y.
3. Batterson, W., and B. Roizman. 1983. Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes. J. Virol. 46:371-377.
4. Bond, J. F., G. S. Robinson, and S. R. Farmer. 1984. Differential expression of two neural cell-specific β-tubulin mRNAs during rat brain development. Mol. Cell. Biol. 4:1313-1319.
5. Bond, V. C., and S. Person. 1984. Fine structure physical map locations of alterations that affect cell fusion in herpes simplex virus type 1. Virology 132:368-376.
6. Cai, W., and P. A. Schaffer. 1992. Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells. J. Virol. 66:2904-2915.
7. Cai, W. H., T. L. Astor, L. M. Liptak, C. Cho, D. M. Coen, and P. A. Schaffer. 1993. The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency. J. Virol. 67:7501-7512.
8. Campbell, M. E., J. W. Palfreyman, and C. M. Preston. 1984. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate-early transcription. J. Mol. Biol. 180:1-19.
9. Carrozza, M. J., and N. A. DeLuca. 1996. Interaction of the viral activator protein ICP4 with TFIID through TAF250. Mol. Cell. Biol. 16:3085-3093.
10. Chakrabarti, S., K. Brechling, and B. Moss. 1985. Vaccinia virus expression vector: coexpression of β-galactosidase provides visual screening of recombinant virus plaques. Mol. Cell. Biol. 5:3403-3409.
11. Chapman, C. J., J. D. Harris, M. A. Hardwicke, R. M. Sandri-Goldin, M. K. Collins, and D. S. Latchman. 1992. Promoter independent activation of heterologous virus gene expression by the herpes simplex virus immediate-early protein ICP27. Virology 186:573-578.
12. Chen, J., X. Zhu, and S. Silverstein. 1991. Mutational analysis of the sequence encoding ICP0 from herpes simplex virus type I. Virology 180: 207-220.
13. Chiocca, E. A., B. B. Choi, W. Cai, N. A. DeLuca, P. A. Schaffer, M. DiFiglia, X. O. Breakefield, and R. L. Martuza. 1990. Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol. 2:739-746.
14. Clements, G. B., and N. D. Stow. 1989. A herpes simplex virus type 1 mutant containing a deletion within immediate-early gene 1 is latency competent in mice. J. Gen. Virol. 70:2501-2506.
15. Clements, J. B., R. J. Watson, and N. M. Wilkie. 1977. Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome. Cell 12:275-285.
16. DeLuca, N. A., M. A. Courtney, and P. A. Schaffer. 1984. Temperature-sensitive mutants in HSV-1 ICP4 permissive for early gene expression. J. Virol. 52:767-776.
17. DeLuca, N. A., A. McCarthy, and P. A. Schaffer. 1985. Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J. Virol. 56:558-570.
18. DeLuca, N. A., and P. A. Schaffer. 1985. Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4. Mol. Cell. Biol. 5:1997-2008.
19. DeLuca, N. A., and P. A. Schaffer. 1987. Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides. Nucleic Acids Res. 15:4491-4511.
20. DeLuca, N. A., and P. A. Schaffer. 1988. Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4. J. Virol. 62:732-743.
21. Desai, P., R. Ramakrishnan, Z. W. Lin, B. Osak, J. C. Glorioso, and M. Levine. 1993. The RR1 gene of herpes simplex virus type 1 is uniquely transactivated by ICP0 during infection. J. Virol. 67:6125-6135.
22. Dixon, R. A. F., and P. A. Schaffer. 1980. Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175. J. Virol. 36:189-203.
23. Dyck, J. A., G. G. Maul, W. H. Miller, Jr., J. D. Chen, A. Kakizuka, and R. M. Evans. 1994. A novel macromolecular structure is a target of the promyelocytic-retinoic acid receptor oncoprotein. Cell 76:333-343.
24. Everett, R. D. 1984. Transactivation of transcription by herpesvirus products: requirements of two HSV-1 immediate-early polypeptides for maximum activity. EMBO J. 3:3135-3141.
25. Everett, R. D. 1987. A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1. EMBO J. 6:2069-2076.
26. Everett, R. D. 1988. Promoter sequence and cell type can dramatically affect the efficiency of transcriptional activation induced by herpes simplex virus type 1 and its immediate-early gene products Vmw175 and Vmw110. J. Mol. Biol. 203:739-751.
27. Everett, R. D., and G. G. Maul. 1994. HSV-1 IE protein Vmw110 causes redistribution of PML. EMBO J. 13:5062-5069.
28. Gelman, I. H., and S. Silverstein. 1985. Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA 82:5265-5269.
29. Gelman, I. H., and S. Silverstein. 1986. Co-ordinate regulation of herpes simplex virus gene expression is mediated by the functional interaction of two immediate-early gene products. J. Mol. Biol. 191:395-409.
30. Gerster, T., and R. G. Roeder. 1988. A herpesvirus transactivating protein interacts with transcription factor OTF-1 and other cellular proteins. Proc. Natl. Acad. Sci. USA 85:6347-6351.
31. Coding, C. R., and P. O'Hare. 1989. Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription. Virology 173:363-367.
32. Godowski, P. J., and D. M. Knipe. 1986. Transcriptional control of herpes-virus gene expression: gene functions required for positive and negative regulation. Proc. Natl. Acad. Sci. USA 83:256-260.
33. Golden, M. P., S. Kim, S. M. Hammer, E. A. Ladd, P. A. Schaffer, N. DeLuca, and M. A. Albrecht. 1992. Activation of human immunodeficiency virus by herpes simplex virus. J. Infect. Dis. 166:494-499.
34. Goldstein, D. J., and S. K. Weller. 1988. Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant. J. Virol. 62:196-205.
35. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus type 5 DNA. Virology 52:456-467.
36. Greaves, R., and P. O'Hare. 1989. Separation of requirements for protein-DNA complex assembly from those for functional activity in the herpes simplex virus regulatory protein Vmw65. J. Virol. 63:1641-1650.
37. Gu, B., and N. A. DeLuca. 1994. Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4. J. Virol. 68:7953-7965.
38. Gu, B., R. Rivera-Gonzalez, C. A. Smith, and N. A. DeLuca. 1993. Herpes simplex virus infected cell polypeptide 4 preferentially represses Sp1-activated over basal transcription from its own promoter. Proc. Natl. Acad. Sci. USA 90:9528-9532.
39. Hardwicke, M. A., and R. M. Sandri-Goldin. 1994. The herpes simplex virus regulatory protein ICP27 can cause a decrease in cellular mRNA levels during infection. J. Virol. 68:4797-4810.
40. Hardy, W. R., and R. M. Sandri-Goldin. 1994. Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect. J. Virol. 68:7790-7799.
41. Harris, R. A., R. D. Everett, X. Zhu, S. Silverstein, and C. M. Preston. 1989. Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system. J. Virol. 63:3513-3515.
42. Honess, R. W., and B. Roizman. 1974. Regulation of herpes virus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J. Virol. 14:8-19.
43. Honess, R. W., and B. Roizman. 1975. Regulation of herpes virus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. Proc. Natl. Acad. Sci. USA 72:1276-1280.
44. Imbalzano, A. N., D. Coen, and N. A. DeLuca. 1991. Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene. J. Virol. 65:565-574.
45. Johnson, P. A., M. J. Wang, and T. Friedman. 1994. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J. Virol. 68:6347-6362.
46. Johnson, P. A., A. Miyanohara, F. Levine, T. Cahill, and T. Friedman. 1992. Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J. Virol. 66:2952-2965.
47. Koken, M. H. M., F. Puvion-Dutilleul, M. Guillemin, A. Viron, G. Linares-Cruz, N. Stuurman, L. De Jong, C. Szostecki, F. Calvo, C. Chomienne, L. Degos, E. Puvion, and H. De The. 1994. The t(15;17) translocation alters a nuclear body in a retinoic acid reversible fashion. EMBO J. 13:1073-1083.
48. Kristie, T. M., J. H. LeBowitz, and P. A. Sharp. 1989. The octamer-binding proteins form multi-protein-DNA complexes with the HSV alpha TIF regulatory protein. EMBO J. 8:4229-4238.
49. Kristie, T. M., and B. Roizman. 1984. Host cell proteins bind to the cis-acting site required for virion mediated induction of herpes simplex virus 1 a genes. Proc. Natl. Acad. Sci. USA 84:71-75.
50. Laemmli, U. K. 1979. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227:680-684.
51. Leib, D. A., D. M. Coen, C. L. Bogard, K. A. Hicks, D. R. Yager, D. M. Knipe, K. L. Tyler, and P. A. Schaffer. 1989. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J. Virol. 63:759-768.
52. Leopardi, R., and B. Roizman. 1996. The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia. Proc. Natl. Acad. Sci. USA 93:9583-9587.
53. Mackern, S., and B. Roizman. 1980. Regulation of herpesvirus macromolecular synthesis: transcription initiation sites and domains of α genes. Proc. Natl. Acad. Sci. USA 79:4917-4921.
54. Mackem, S., and B. Roizman. 1982. Structural features of the α gene 4, 0, and 27 promoter-regulatory sequences which confer α regulation on chimeric thymidine kinase genes. J. Virol. 44:939-949.
55. Manservigi, R., P. Spear, and A. Buchan. 1977. Cell fusion induced by herpes simplex virus is promoted and suppressed by different viral glycoproteins. Proc. Natl. Acad. Sci. USA 74:3913-3917.
56. Maul, G. G., and R. D. Everett. 1994. The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0. J. Gen. Virol. 75:1223-1233.
57. Maul, G. G., H. H. Guldner, and J. G. Spivack. 1993. Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate-early gene 1 product (ICP0). J. Gen. Virol. 74:2679-2690.
58. McCarthy, A. M., L. McMahan, and P. A. Schaffer. 1989. Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA-deficient. J. Virol. 63:18-27.
59. McLauchlan, J., A. Phelan, C. Loney, R. M. Sandri-Goldin, and J. B. Clements. 1992. Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3′ processing. J. Virol. 66:6939-6945.
60. McLauchlan, J., S. Simpson, and J. B. Clements. 1989. Herpes simplex virus induces a processing factor that stimulates poly(A) site usage. Cell 59:1093-1105.
61. McMahan, L., and P. A. Schaffer. 1990. The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection. J. Virol. 64:3471-3485.
62. Meredith, M. R., A. Orr, M. Elliot, and R. D. Everett. 1995. Separation of the sequence requirements for HSV1 Vmw110 multimerisation and interaction with a 135kD cellular protein. Virology 209:174-187.
63. Meredith, M. R., A. Orr, and R. D. Everett. 1994. Herpes simplex virus type 1 immediate-early protein Vmw110 binds strongly and specifically to a 135kD cellular protein. Virology 200:457-469.
64. Michael, N., and B. Roizman. 1993. Repression of the herpes simplex virus 1 alpha 4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites. Proc. Natl. Acad. Sci. USA 90:2286-2290.
65. O'Hare, P., C. R. Goding, and A. Haigh. 1988. Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression. EMBO J. 7:4231-4238.
66. O'Hare, P., and G. S. Hayward. 1985. Evidence for a direct role for both the 175,000-and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters. J. Virol. 53:751-760.
67. O'Hare, P., and G. S. Hayward. 1985. Three transactivating regulatory proteins of herpes simplex virus modulate immediate early gene expression in a pathway involving positive and negative feedback regulation. J. Virol. 56:723-733.
68. Pereira, L., M. H. Wolff, M. Fenwick, and B. Roizman. 1977. Regulation of herpes virus macromolecular synthesis. V. Properties of polypeptides made in HSV-1 and HSV-2 infected cells. Virology 77:733-749.
69. Preston, C. M. 1979. Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK. J. Virol. 29:275-284.
70. Quinlan, M. P., and D. M. Knipe. 1985. Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions. Mol. Cell. Biol. 5:957-963.
71. Rice, S. A., and D. M. Knipe. 1988. Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27. J. Virol. 62:3814-3823.
72. Roberts, M. S., A. Boundy, P. O'Hare, M. C. Pizzorno, D. M. Ciufo, and G. S. Hayward. 1988. Direct correlation between a negative autoregulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein. J. Virol. 62:4307-4320.
73. Sacks, W. R., C. C. Greene, D. P. Aschman, and P. A. Schaffer. 1985. Herpes simplex virus type 1 ICP27 is an essential regulatory protein. J. Virol. 55:796-805.
74. Sacks, W. R., and P. A. Schaffer. 1987. Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture. J. Virol. 61:829-839.
75. Samaniego, L. A., and N. A. DeLuca. Unpublished observations.
76. Samaniego, L. A., A. L. Webb, and N. A. DeLuca. 1995. Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4. J. Virol. 69:5705-5715.
77. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
78. Sandri-Goldin, R. M. 1994. Properties of an HSV-1 regulatory protein that appears to impair host cell splicing. Infect. Agents Dis. 3:59-67.
79. Sandri-Goldin, R. M., M. K. Hibbard, and M. A. Hardwicke. 1995. The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing. J. Virol. 69:6063-6076,
80. Sandri-Goldin, R. M., and G. E. Mendoza. 1992. A herpes virus regulatory protein appears to act posttranscriptionally by affecting mRNA processing. Genes Dev. 6:848-863.
81. Sekulovich, R. E., K. Leary, and R. M. Sandri-Goldin. 1988. The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0. J. Virol. 62:4510-4522.
82. Shepard, A. A., and N. A. DeLuca. 1989. Intragenic complementation among partial peptides of herpes simplex regulatory protein ICP4. J. Virol. 63:1203-1211.
83. Shepard, A. A., A. N. Imbalzano, and N. A. DeLuca. 1989. Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4. J. Virol. 63:3714-3728.
84. Smith, C. A., P. Bates, R. Rivera-Gonzales, B. Gu, and N. A. DeLuca. 1993. ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. J. Virol. 67:4676-4687.
85. Smith, I. L., M. A. Hardwicke, and R. M. Sandri-Goldin. 1992. Evidence that the herpes simplex virus immediate early protein ICP27 acts posttranscriptionally during infection to regulate gene expression. Virology 186:74-86.
86. Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503-517.
87. Southern, P. J., and P. Berg. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1:327-341.
88. Stow, N. D., and E. C. Stow. 1986. Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate-early polypeptide Vmw110. J. Gen. Virol. 67:2571-2585.
89. Su, L., and D. M. Knipe. 1989. Herpes simplex virus alpha protein ICP27 can inhibit or augment viral gene transactivation. Virology 170:496-504.
90. Sze, P., and R. C. Herman. 1992. The herpes simplex virus type 1 ICP6 gene is regulated by a 'leaky' early promoter. Virus Res. 26:141-152.
91. Triezenberg, S. J., K. L. LaMarco, and S. L. McKnight. 1988. Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16. Genes Dev. 2:730-742.
92. Uprichard, S. L., and D. M. Knipe. 1996. Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes. J. Virol. 70:1969-1980.
93. Watson, R. J., C. M. Preston, and J. B. Clements. 1979. Separation and characterization of herpes simplex virus type 1 immediate-early mRNAs. J. Virol. 31:42-52.
94. Watson, R. J., and J. B. Clements. 1978. Characterization of transcription-deficient temperature-sensitive mutants of herpes simplex virus type 1. Virology 91:364-379.
95. Weinheimer, S. P., and S. L. McKnight. 1987. Transcriptional and posttranscriptional controls establish the cascade of herpes simplex virus protein synthesis. J. Mol. Biol. 195:819-833.
96. Weis, K., S. Rambaud, C. Lavau, J. Jansen, T. Carvalho, M. Carmo-Fonseca, A. Lamond, and A. Dejean. 1994. Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukaemia cells. Cell 76:345-356.
97. Wilcox, K. W., A. Kohn, E. Sklyanskaya, and B. Roizman. 1980. Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA. J. Virol. 33:167-182.
98. Wu, N., S. C. Watkins, P. A. Schaffer, and N. A. DeLuca. 1996. Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J. Virol. 70:6358-6369.
99. Wymer, J. P., T. D. Chung, Y.-N. Chang, G. S. Hayward, and L. Aurelian. 1989. Identification of immediate-early-type cis-response elements in the promoter for the ribonucleotide reductase large subunit from herpes simplex virus type 2. J. Virol. 63:2773-2784.
100. Zhu, X. X., J. Chen, C. S. H. Young, and S. Silverstein. 1990. Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products. J. Virol. 64:4489-4498.