Synthesis of multiply substituted, ion channel forming octi(p-phenylene)s: Theme and variations

Organic Letters

Volumn 2, Issue 1, 2000, Pages 37-39

  Robert, Fabien ^a   Winum, Jean Yves ^a,b   Sakai, Naomi ^a,b   Gerard, David ^a   Matile, Stefan ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ETHER DERIVATIVE; ION CHANNEL;

ARTICLE; CELL MEMBRANE; DRUG EFFECT; METABOLISM; SYNTHESIS;

ANTI-INFECTIVE AGENTS; CELL MEMBRANE; ETHERS, CYCLIC; ION CHANNELS;

EID: 0033644355     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol991210n     Document Type: Article

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38. 1 Preliminary results in black lipid membranes (EYPC-BLMs) revealed single channel currents in the range of 1-40 pA at high voltages. Detailed studies on structure and activity of 3/4 and their now accessible positively charged analogues in SUVs, BLMs, and bacteria are ongoing.