Modular control over the selectivity of self-assembling and membrane- spanning ion conductors [8]

Journal of the American Chemical Society

Volumn 121, Issue 31, 1999, Pages 7276-7277

  Otto, Sijbren ^a   Osifchin, Manette ^a   Regen, Steven L ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTON; SODIUM ION;

ION CONDUCTANCE; ION TRANSPORT; KINETICS; LETTER; LIPID MEMBRANE; MOLECULAR DYNAMICS; SYNTHESIS;

EID: 0033546679     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja990505t     Document Type: Letter

References (27)

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16. In this paper, we refer to assemblies of these membrane-spanning synthetic ionophores as "ion conductors" as opposed to naturally occurring "channel formers", which produce trans-membrane channels or pores through which selected ions can diffuse: Voet, D.; Voet, J. G. Biochemistry; John Wiley & Sons: New York, 1990; Chapter 18.
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23. 1 The maximum concentration of 2 that was tested was 1 mol %.
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26. An attractive model for membrane-spanning dimers that we currently favor is one that is analogous to gramicidin-based dimers, where two hairpin-like conformations lie in the two leaflets of the bilayer and form end-to-end dimers.
27. In preliminary studies, we have found that 2 leads to a large conductance in membranes formed from diphytanoyl PC. However, the observed conductance was found to be quiet, indicating that any channels, if present, are quite small.