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Volumn 121, Issue 5, 1999, Pages 931-940

Incremental conversion of outer-membrane permeabilizers into potent antibiotics for gram-negative bacteria

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROSTREPTOMYCIN; ERYTHROMYCIN; POLYMYXIN B; POLYMYXIN DERIVATIVE;

EID: 0033540629     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja982938m     Document Type: Article
Times cited : (135)

References (45)
  • 7
    • 0013853931 scopus 로고
    • For examples see: (a) Beacham, I. R.; Kahana, R.; Levy, L.; Yagil, E. J. Bacteriol. 1973, 116, 957. (b) Brown, M. R. W.; Richards, R. M. E. Nature 1965, 207, 1391.
    • (1965) Nature , vol.207 , pp. 1391
    • Brown, M.R.W.1    Richards, R.M.E.2
  • 9
    • 0019866623 scopus 로고
    • For examples see: (a) Hancock, R. E. W.; Raffle, V. J.; Nicas, T. I. Antimocrob. Agents Chemother. 1981, 19, 777. (b) Reynolds, B. L.; Pruul, H. Infect. Immun. 1971, 3, 365.
    • (1971) Infect. Immun. , vol.3 , pp. 365
    • Reynolds, B.L.1    Pruul, H.2
  • 33
    • 0344057367 scopus 로고    scopus 로고
    • note
    • Many clinically useful antibiotics against Gram-negative bacteria have MIC values of ca. 1 μg/mL (see ref 14).
  • 34
    • 0344919702 scopus 로고    scopus 로고
    • note
    • Obtained from Boehringer Mannheim as 95% pure PMBN and used as received.
  • 35
    • 0344488589 scopus 로고    scopus 로고
    • note
    • Permeabilization is classified as a "sublethal action"; see ref 3a. DAPB (3), PMBN (4), PMBH (5), and 6-11 can cause increases in permeability at concentrations much lower than their corresponding MBC values.
  • 39
    • 0345350964 scopus 로고    scopus 로고
    • note
    • P. aeruginosa strains are typically more antibiotic resistant than strains of E. coli; see ref 14.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.