Structure-function study on a de novo synthetic hydrophobic ion channel

Biophysical Journal

Volumn 76, Issue 2, 1999, Pages 631-641

  Qi, Zhi ^a   Sokabe, Masahiro ^a   Donowaki, Kiyoshi ^b   Ishida, Hitoshi ^c  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ION; ION CHANNEL;

ARTICLE; DISSOCIATION CONSTANT; DOSE RESPONSE; ELECTRIC POTENTIAL; ION CONDUCTANCE; ION TRANSPORT; KINETICS; MICHAELIS CONSTANT; PERMEABILITY; STRUCTURE ACTIVITY RELATION;

EID: 0033027022     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(99)77231-0     Document Type: Article

References (37)

1. Alvarez, O., A. Villarroel, and G. Eisenman. 1992. Calculation of ion currents from energy profiles and energy profiles from ion currents in multibarrier, multisite, multioccupancy channel model. Methods Enzymol. 207:816-854.
2. Andersen, O. S., and R. E. Koeppe II. 1992. Molecular determinants of channel function. Physiol. Rev. 72:S89-S158.
3. + channel of sarcoplasmic reticulum. Biophys. J. 45:279-287.
4. Chang, H., S. Ciani, and Y. Kidokoro. 1994. Ion permeation properties of the glutamate receptor channel in cultured embryonic Drosophila myotubes. J. Physiol. 476:1-16.
5. Chen, D. P., and R. S. Eisenberg. 1993. Flux, coupling, and selectivity in ionic channels of one conformation. Biophys. J. 65:727-746.
6. +-selective channel from sarcoplasmic reticulum incorporated into planar phospholipid bilayers. J. Gen. Physiol. 79:529-547.
7. Donowaki, K., K. Ohkubo, and H. Ishida. 1996. Molecular design and synthesis of functional peptides which include a non-natural amino acid. Peptide Chem. 413-416.
8. n. J. Phys. Chem. 74:1466-1474.
9. Egberts, E., S. J. Marrink, and H. J. C. Berendsen. 1994. Molecular dynamics simulation of a phospholipid membrane. Eur. Biophys. J. 22:423-436.
10. Hayashi, F., M. Sokabe, M. Takagi, K. Hayashi, and U. Kishimoto. 1978. Calcium-sensitive univalent cation channel formed by lysotriphosphoinositide in planar bilayer lipid membranes. Biochim. Biophys. Acta. 510:305-315.
11. Heginbotham, L., and R. MacKinnon. 1992. The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron. 8:483-491.
12. Hille, B. 1971. The permeability of the sodium channel to organic cations in myelinated nerve. J. Gen. Physiol. 58:599-619.
13. Hille, B. 1992. Ionic channels of excitable membranes, 2nd ed. Sunderland. MA, Sinauer.
14. Ishida, H., K. Donowaki, Y. Inoue, Z. Qi, and M. Sokabe. 1997. Synthesis and ion channel formation of novel cyclic peptides that include a non-natural amino acid. Chem. Lett. 935-954.
15. Jordan, P. C. 1986. Ion channel electrostatics and the shapes of channel proteins. In Ion Channel Reconstitution. C. Miller, editor. Plenum Press, New York. 37-55.
16. Jordan, P. C. 1990. Ion-water and ion-polypeptide correlations in a gramicidin-like channel: a molecular dynamics study. Biophys. J. 58: 1133-1156.
17. Karlin, A., and M. H. Akabas. 1995. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron. 15:1231-1244.
18. Kobuke, Y., K. Ueda, and M. Sokabe. 1992. Artificial non-peptide single ion channels. J. Am. Chem. Soc. 114:7618-7622.
19. Kumpf, R. A., and D. A. Dougherty. 1993. A mechanism for ion selectivity in potassium channels: computational studies of cation-π interactions. Science. 261:1708-1710.
20. Lear, J. D., Z. R. Wasserman, and W. F. DeGrado. 1988. Synthetic amphiphilic peptide models for protein ion channels. Science. 240: 1177-1181.
21. Levitt, D. G. 1978. Electrostatic calculations for an ion channel. I. Energy and potential profiles and interaction between ions. Biophys. J. 22: 209-219.
22. Levitt, D. G. 1986. Interpretation of biological ion channel flux data: reaction-rate versus continuum theory. Annu. Rev. Biophys. Biophys. Chem. 15:29-57.
23. Miller, C. 1993. Potassium selectivity in proteins: oxygen cage or π in the face? Science. 261:1692-1693.
24. + channel from rat brain synaptosomal membranes incorporated into planar bilayers. J. Membr. Biol. 115:241-251.
25. Oiki, S., W. Danho, V. Madison, and M. Montal. 1988a. M2 delta, a candidate for the structure lining the ionic channel of the nicotinic cholinergic receptor. Proc. Natl. Acad. Sci. U.S.A. 85:8703-8707.
26. Oiki, S., W. Danho, and M. Montal. 1988b. Channel protein engineering: synthetic 22-mer peptide from the primary structure of the voltage-sensitive sodium channel forms ionic channels in lipid bilayers. Proc. Natl. Acad. Sci. U.S.A. 85:2393-2397.
27. Oliver, A. E., and D. W. Deamer. 1994. α-Helical hydrophobic polypeptides form proton-selective channels in lipid bilayers. Biophys. J. 66: 1364-1379.
28. Pregel, M. J., L. Jullien, J. Canceill, L. Lacombe, and J. M. Lehn. 1995. Channel-type molecular structures. IV. Transmembrane transport of alkali-metal ions by 'bouquet' molecules. J. Chem. Soc. 2:417-426.
29. Qi, Z., and M. Sokabe. 1998. Dynamic properties of individual water molecules in a hydrophobic pore lined with acyl chains: a molecular dynamics study. Biophys. Chem. 71:35-50.
30. Roux, B., and M. Karplus. 1994. Molecular dynamics simulations of the gramicidin channel. Annu. Rev. Biophys. Biomol. Struct. 23:731-761.
31. Sokabe, M. 1984. Aminoglycoside blockade of cation channels from polyphopsphoinositides and sarcoplasmic reticulum in planar bilayer lipid membranes. In Transmembrane Signaling and Sensation. F. Oosawa, H. Hayashi, and T. Yoshioka, editors. JSSP/VNU Science Press, Tokyo. 119-134.
32. Sokabe, M., A. Auerbach, and F. J. Sigworth (editors). 1997. Progress in Cell Research, Vol. 6: Towards Molecular Biophysics of Ion Channels. Elsevier Science, Amsterdam.
33. + channel. Comp. Biochem. Physiol. 98C:23-30.
34. Sokabe, M., Z. Qi, H. Ishida, and K. Donowaki. 1996. Ion channels formed from cyclic peptides with acyl chains. Biophys. J. 70:A201.
35. +-selective filter. Angew. Chem. Int. Edit. 34:693-694.
36. Tempel, B. L., D. M. Papazian, T. L. Schwarz, Y. N. Jan, and L. Y. Jan. 1987. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science. 237:770-775.
37. Woodhull, A. M. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.