The β-slip: A novel concept in transthyretin amyloidosis

Molecular Cell

Volumn 6, Issue 5, 2000, Pages 1207-1218

  Eneqvist, Therese ^a   Andersson, Karin ^a   Olofsson, Anders ^a   Lundgren, Erik ^a   Sauer Eriksson, A Elisabeth ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE; PREALBUMIN; RETINOL BINDING PROTEIN; SERINE;

AMYLOIDOSIS; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; HUMAN; MODEL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

EID: 0033635284     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1097-2765(00)00117-9     Document Type: Article

References (64)

1. Transthyretin amyloidosis
2. Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix
3. Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8Å
4. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
5. Crystallography and NMR system: A new software suite for macromolecular structure determination
6. Electron microscopy of amyloid
7. The CCP4 suite: Programs for protein crystallography
8. Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro
9. Tabulation of transthyretin (TTR) variants as of 1/1/2000
10. The atomic structure of protein-protein recognition sites
11. Characterization of a transthyretin (prealbumin) variant associated with familial amyloidotic polyneuropathy type II (Indiana/Swiss)
12. Negative cooperativity in the binding of thyroxin of thyroxine to human serum prealbumin
13. The preaggregated state of an amyloidogenic protein: Hydrostatic pressure converts native transthyretin into the amyloidogenic state
14. Characterization of two highly amyloidogenic mutants of transthyretin
15. Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants
16. Amyloid fibril composition and transthyretin gene structure i nsenile systemic amyloidosis
17. The X-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30 → Met variant to 1.7 Å resolution
18. A comparative analysis of 23 structures of the amyloidogenic protein transthyretin
19. Analysis of x-ray diffraction patterns from amyloid of biopsied vitreous humor and kidney of transthyretin (TTR) Met30 familial amyloidotic polyneuropathy (FAP) patients: Axially arrayed TTR monomers cosntitute the protofilament
20. Transthyretin Pro55, a variant associated with early-onset, aggressive, difuse amyloidosis with cardiac and neurologic involvement
21. Protein-protein interaction at crystal contacts
22. Improved methods for building protein models in electron density maps and the location of errors in these models
23. Retinol-binding protein: The transport protein for vitamin A in human plasma
24. Alternative conformations of amyloidogenic proteins govern their behavior
25. The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways
26. A chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid fibril formation
27. Rational design of potent human transthyretin amyloid disease inhibitors
28. Halloween... masks and bones
29. Amyloid diseases: Abnormal protein aggregation in neurodegeneration
30. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
31. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid
32. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: Implications for wild-type, V30M, and L55P amyloid fibril formation
33. The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions
34. Main-chain bond lengths and bond angles in protein structures
35. Proteoglycans and the extracellular matrix in amyloidosis
36. Solvent content of protein crystals
37. Transthyretin mutation Leu-55-Pro significantly alters tetramere stability and increases amyloidogenicity
38. Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease
39. Raster3D Photorealistic molecular graphics
40. Structure of a complex of two plasma proteins: Transthyretin and retinol-binding protein
41. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxyl terminus of RBP
42. Protein subunit interactions and structural integrity of amyloidogenic transthyretins: Evidence from electrospray mass spectrometry
43. Processing and x-ray diffractions data collected in oscillation mode
44. Amyloidosis
45. Amyloid P component: A critical review
46. WARP: Improvement and extension of crystallographic phases by weighted averaging of multiple refined dummy atomic models
47. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation
48. On the binding of Congo red by amyloid
49. A review of light, polarization and fluorescence microscopic methods for amyloid
50. Designing transthyretin mutants affecting tetrameric structure: Implications in amyloidogenicity
51. Proteins associated with thyroid hormones
52. Amyloid fibrillogenesis: Themes and variations
53. Transthyretin mutations in health and disease
54. A simple method for making reproducible fibre loops for protein cryocrystallography
55. The crystal structure of amyloidogenic Leu55-Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils
56. Examination of the structure of the transthyretin amyloid fibril by image reconstruction from electron micrographs
57. The 'edge-strand' hypothesis: Prediction and test of a mutational 'hot-spot' on the transthyretin molecule associated with FAP amyloidogenesis
58. Common core structure of amyloid fibrils by synchrotron X-ray diffraction
59. Modifications of transthyretin in amyloid fibrils. Analysis of amyloid from homozygous and heterozygous individuals with the Met30 mutation
60. Biochemical and molecular genetic characterization of a new variant prealbumin associated with hereditary amyloidosis
61. Fibril in senile systemic amyloidosis is derived from normal transthyretin