Designing transthyretin mutants affecting tetrameric structure: Implications in amyloidogenicity

Biochemical Journal

Volumn 348, Issue 1, 2000, Pages 167-172

  Redondo, Clara ^a,b   Damas, Ana M ^a,b   Saraiva, Maria João M ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Amyloid; Amyloid neuropathy; Thyroxine; Transthyretin

Indexed keywords

ALANINE; AMYLOID; ASPARAGINE; ASPARTIC ACID; CYSTEINE; DIMER; GLUTAMIC ACID; LEUCINE; MERCAPTOETHANOL; MONOMER; MUTANT PROTEIN; PREALBUMIN; SERINE; TETRAMER;

ARTICLE; CONTROLLED STUDY; DISSOCIATION; DISULFIDE BOND; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR STABILITY; PH; PRIORITY JOURNAL;

AMYLOID NEUROPATHIES; BIOPOLYMERS; DIMERIZATION; ESCHERICHIA COLI; MODELS, MOLECULAR; PREALBUMIN; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS;

EID: 0034657815     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3480167     Document Type: Article

References (20)

1. 1 Saraiva, M. J. M. (1996) Molecular genetics of Familial Amyloidotic Polyneuropathy. J. Peripher. Nerv. Syst. 1, 179-188
2. 2 Wojtczak, A., Cody, V., Luft, J. R. and Paugborn, W. (1996) Structures of human transthyretin complexed with thyroxine at 2.0 Å resolution and 3′, 5′-dinitro-N-acetyl-L-thyroxine at 2.2 Å resolution. Acta Cryst. D52, 758-765
3. 3 Monaco, H. L., Rizzi, M. and Coda, A. (1995) Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science 268, 1039-1041
4. 4 Bonifácio, M. J., Sakaki, Y. and Saraiva, M. J. (1996) In vitro amyloid formation from transthyretin: the influence of ions and the amyloidogenicity of TTR variants. Biochim. Biophys. Acta 1316, 35-42
5. 5 Damas, A. M., Ribeiro, S., Lamzin, V. S., Palha, J. A. and Saraiva, M. J. (1996) Structure of Val122lle variant transthyretin - a cardiomyopathic mutant. Acta Cryst. D52, 966-972
6. 6 Sebastião, M. P., Saraiva, M. J. M. and Damas, A. M. (1998) The crystal structure of amyloidogenic Leu55Pro transthyretin variant reveals a possible pathway for transthyretin polymerisation into amyloid fibrils. J. Biol. Chem. 273, 24715-24722
7. 7 Lai, Z., Colon, W. and Kelly, J. W. (1996) The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid. Biochemistry 35, 6470-6482
8. 8 Blake, C. and Serpell, L. (1996) Synchroton X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix. Structure 4, 989-998
9. 9 Inouye, H., Domingues, F. S., Damas, A. M., Saraiva, M. J., Lundgren, E., Sandgren, O. and Kirschner, D. A. (1998) Analysis of X-ray diffraction patterns from amyloid of biopsied vitreous humor and kidney of transthyretin (TTR) Met30 Familial Amyloidotic Polyneuropathy (FAP) patients: axially arrayed TTR monomers constitute the protofilament. Amyloid 5, 163-174
10. 10 Coelho, T., Chorão, R., Sousa, A., Alves, I. L., Torres, M. F. and Saraiva, M. J. M. (1996) Compound heterozygote of transthyretin Met30 and transthyretin Met119 are protected from the devastating effects of Familial Amyloid Polyneuropathy. Neuromuscular Dis. 6, S20
11. 11 Alves, I. L., Hays, M. T. and Saraiva, M. J. M. (1996) Comparative stability and clearance of Met30 transthyretin and Met119 transthyretin. Eur. J. Biochem. 249, 662-668
12. 12 Roussel, A. and Cambillau, C. (1989). In Turbo-Frodo. Silicon Graphics Geometry Partners Directory, pp. 77-78. Silicon Graphics, Mountain View, CA, U.S.A.
13. 13 Almeida, M. R., Damas, A. M., Lans, M. C., Brouwer, A. and Saraiva, M. J. (1997) Thyroxine binding to transthyretin Met119. Endocrine 6, 309-215
14. 14 Furuya, H., Saraiva, M. J. M., Gawinowicz, M. A., Alves, I. L., Costa, P. P., Sasaki, H., Goto, I. and Sakaki, Y. (1991) Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of Familial Amyloidotic Polyneuropathy (FAP). Biochemistry 30, 2415-2421
15. 15 Saraiva, M. J. M., Costa, P. P. and Goodman, D. S. (1988) Transthyretin (prealbumin) in familial amyloidotic polyneuropathy: genetic and functional aspects. Adv. Neurol. 48, 201-210
16. 16 Quintas, A., Saraiva, M. J. M. and Brito, R. M. M. (1997) The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution. FEBS Lett. 418, 297-300
17. 17 Saraiva, M. J. M., Birken, S., Costa, P. P. and Goodman, D. S. (1984) Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of a molecular abnormality in transthyretin (prealbumin). J. Clin. Invest. 74, 104-119
18. 18 Colón, W. and Kelly, J. W. (1992) Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry 31, 8654-8660
19. 19 Blake, C. C. F., Geisow, M. J., Oatley, S. J., Rérat, B. and Rérat, C. (1978) Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å. J. Mol. Biol. 121, 339-356
20. 20 Blake, C. C. F., Burridge, J. M. and Oatley, S. J. (1978) X-ray analysis of thyroid hormone binding to prealbumin. Biochem. Soc. Trans. 6, 1114-1118