Comparison of β-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: Amorphic plaques and cytoskeletal changes occur independently

Acta Neuropathologica

Volumn 96, Issue 2, 1998, Pages 129-138

  Van De Nes, J A P ^a,b,c   Kamphorst, W ^b   Ravid, R ^a   Swaab, D F ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

protein; Alz 50; Alzheimer's disease; Cytoskeletal changes; Human hypothalamus

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; FEMALE; HUMAN; HYPOTHALAMUS; MALE; NERVE ENDING; NEUROPATHOLOGY; PRIORITY JOURNAL; SENILE PLAQUE;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANTIGENS; COLORING AGENTS; CYTOSKELETON; FEMALE; HUMANS; HYPOTHALAMUS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; SENILE PLAQUES;

EID: 0031847513     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050872     Document Type: Article

References (41)

1. Allen SJ, Dawbarn D, Wilcock GK (1988) Morphometric immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease. Brain Res 454:275-281
2. Allsop D, Landon M, Kidd M, Lowe JS, Reynolds GP, Gardner A (1986) Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease. Neurosci Lett 68:252-256
3. Axelson JF, Van Leeuwen FW (1990) Differential localization of estrogen receptors in various vasopressin synthesizing nuclei of the rat brain. J Neuroendocrinol 2:209-216
4. Bouras C, Magistretti PJ, Morrison JH, Constantidinis J (1987) An immunohistochemical study of prosomatostatin-derived peptides in the human brain. Neuroscience 22:781-800
5. Braak H, Braak E (1990) Alzheimer's disease: striatal amyloid deposits and neurofibrillary changes. J Neuropathol Exp Neurol 49:215-224
6. Braak H, Braak E (1992) The hypothalamus of the human adult (chiasmatic and tuberal region). Prog Brain Res 93:3-16
7. Braak H, Braak E, Grundke-Iqbal I (1986) Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 65: 351-355
8. Castano EN, Ghiso J, Prelli F, Gorevic PD, Migheli A, Frangione B (1986) In vitro formation of amyloid fibrils from the synthetic peptides of different lengths homologous to Alzheimer's disease. Biochem Biophys Res Commun 141:782-789
9. Gaspar P, Berger B, Lesur A, Borsotti JP, Febvret A (1987) Somatostatin 28 and neuropeptide Y innervation in the septal area and related cortical and subcortical structures of the human brain. Distribution, relationships and evidence for differential coexistence. Neuroscience 22:49-73
10. Glenner GG, Wong CW (1984) Alzheimer's disease and Down's syndrome: share of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122:1131-1135
11. Hardy J (1992) An 'anatomical cascade hypothesis' for Alzheimer's disease. Trends Neurosci 15:200-201
12. Hedreen JC, Struble RG, Whitehouse PJ, Price DL (1984) Topography of the magnocellular basal forebrain system in human brain. J Neuropathol Exp Neurol 43:1-21
13. Hirano A, Zimmerman HM (1962) Alzheimer's neurofibrillary changes: a topographical study. Arch Neurol 7:227-242
14. Ishii T (1966) Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia. Acta Neuropathol (Berl) 6:181-187
15. Kitamoto T, Ogomori K, Tateishi J, Prusiner SB (1987) Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloid. Lab Invest 57:230-236
16. Kremer HPH, Swaab DF, Bots GTAM, Fisser B, Ravid R, Roos RAC (1991) The hypothulamic lateral tuberal nucleus in Alzheimer's disease. Ann Neurol 29:279-284
17. Lee VM-L, Balin BJ, Orvos L, Trojanowski JQ (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 251:675-678
18. Lesur A, Gaspar P, Alvarez C, Berger B (1989) Chemoanatomic compartments in the human bed nucleus of the stria terminalis. Neuroscience 32:181-194
19. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82:4245-4249
20. Mengod G, Rigo M, Savasta M, Probst A, Palacios JM (1992) Regional distribution of neuropeptide somatostatin gene expression in the human brain. Synapse 12:62-74
21. Mesulam M-M, Mufson EJ, Levey AI, Wainer BH (1983) Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata) and hypothalamus in the rhesus monkey. J Comp Neurol 214:170-197
22. Meyer G, Gonzalez-Hernandez T, Carillo-Padilla F, Ferres-Torres R (1989) Aggregations of granule cells in the basal forebrain (islands of Calleja): Golgi and cytoarchitectonic study in different mammals, includine man. J Comp Neurol 284:405-428
23. Reisberg B, Ferris SH, De Leon MJ (1982) The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 139:1136-1139
24. Rinne JO, Paljarvi L, Rinne UK (1987) Neuronal size and density in the nucleus basalis of Meynert in Alzheimer's disease. J Neurol Sei 79:67-76
25. Rozemuller JM, Eikelenboom P, Stam FC, Beyreuther K, Masters CL (1989) A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol 48:674-691
26. Rudelli RD. Ambler MW, Wisniewski HM (1984) Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon. Acta Neuropathol (Berl) 64:273-281
27. Saper CB, Chelimsky TC (1984) A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain. Neuroscience 13:1023-1037
28. Saper CB, German DC (1987) Hypothalamic pathology in Alzheimer's disease. Neurosci Lett 74:364-370
29. Salehi A, Lucassen PJ, Pool CW, Gonatas NK. Ravid R, Swaab DF (1994) Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience 59 871-880
30. Simpson J, Yates CM, Watts AG, Fink G (1988) Congo red birefringent structures in the hypothalamus in senile dementia of the Alzheimer type. Neuropathol Appl Neurobiol 14:381-393
31. Standaert DG, Lee VM-Y, Greenberg BD, Lowery DE, Trojanowski JQ (1991) Molecular features of hypothalamic plaques in Alzheimer's disease. Am J Pathol 139:681-691
32. Sternberger LA (1979) Immunocytochemistry, 2nd. Edn. Wiley, New York
33. Swaab DF, Fliers E, Partiman TS (1985) The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res 342:37-44
34. Swaab DF, Grundke-Iqbal I, Iqbal K, Kremer HPH, Ravid R, Van de Nes JAP (1992) Tau and ubiquitin in the human hypothalamus in aeina and Alzheimer's disease. Brain Res 590: 239-249
35. Tagliavini F, Giaccone G, Frangione B, Bugiani O (1988) Preamyloid deposits in the cerebral cortex ot patients with Alzheimer's disease and nondemented individuals. Neurosci Lett 93: 191-196
36. 1-12 immunoreactivity is decreased in the hypothalamic lateral tuberal nucleus of Huntington's disease patients. Brain Res 728:141-148
37. Van de Nes JAP, Kamphorst W, Ravid R, Swaab DF (1993) Alz-50 immunoreactivity in the hypothalamus and adjoining areas of Alzheimer's disease patients. Brain 115:103-115
38. Van de Nes JAP, Sluiter AA, Pool CW, Kamphorst W, Ravid R, Swaab DF (1994) The monoclonal antibody Alz-50, used to reveal cytoskeletal changes in Alzheimer's disease, also reacts with a large subpopulation of somatostatin neurons in the normal hypothalamus and adjoining areas. Brain Res 655:97-109
39. Vincent IJ, Davies P (1990) Phosphorylation characteristics of the A68 protein in Alzheimer's disease. Brain Res 531:127-135
40. Walter A, Mai JK, Lanta L, Gores T (1991) Differential distribution of immunohistochemical markers in the bed nucleus of the stria terminalis in the human brain. J Chem Neuroanat 4: 281-298
41. Wolozin BL, Pruchnicki A, Dickson DW, Davies P (1986) A neuronal antigen in the brains of Alzheimer patients. Science 232:648-650