Essential thiol requirement to restore pterin- or substrate-binding capability and to regenerate native enzyme-type high-spin heme spectra in the Escherichia coli-expressed tetrahydrobiopterin-free oxygenase domain of neuronal nitric oxide synthase

Biochemistry

Volumn 38, Issue 48, 1999, Pages 15853-15862

  Sono, Masanori ^a   Ledbetter, Amy P ^a   McMillan, Kirk ^b   Roman, Linda J ^c   Shea, Thomas M ^c   Masters, Bettie Sue Siler ^c   Dawson, John H ^a,d  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b PHARMACOPEIA INC   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BRAIN ENZYME; CYSTEINE; DIHYDROBIOPTERIN; DITHIOTHREITOL; FERRIC ION; GLUTATHIONE; HEME; MERCAPTOETHANOL; N(G) METHYLARGININE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; OXYGENASE; PTERIN; QUERCETIN; SEMIQUINONE; TETRAHYDROBIOPTERIN; THIOL DERIVATIVE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISULFIDE BOND; ENZYME BINDING; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BIOPTERIN; CIRCULAR DICHROISM; DITHIOTHREITOL; ESCHERICHIA COLI; HEME; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXYGENASES; PROTEIN BINDING; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; X-RAY DIFFRACTION;

EID: 0033619706     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991580j     Document Type: Article

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