Antigen-independent activation of naive and memory resting T cells by a cytokine combination

Journal of Experimental Medicine

Volumn 180, Issue 3, 1994, Pages 1159-1164

  Unutmaz, Derya ^a   Pileri, Piero ^a   Abrignani, Sergio ^a  

^a Instituto Ricerche Immunobiol Siena   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 6; T LYMPHOCYTE RECEPTOR;

ARTICLE; B LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD45; HUMAN; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; RECEPTORS, INTERLEUKIN-2; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR;

EID: 0027935476     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.180.3.1159     Document Type: Article

References (24)

1. Carding, S.R., W. Allan, A. McMickle, and P. Doherty. 1993. Activation of cytokine genes in T cells during primary and secondary murine influenza. J. Exp Med. 177:475.
2. Grossman, Z., and W.E. Paul. 1992. Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. Proc. Natl. Acad. Sei. USA. 89:10365.
3. + T cells specific for conserved regions of human immunodeficiency virus glycoprotein gpl20 in humans immunized with a recombinant envelope protein. Proc. Natl. Acad. Sei. USA. 87:6136.
4. Schmid, I., C.H. Uittenbogaart, and J.V. Giorgi. 1991. A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification. Cytometry. 12:279.
5. + T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. J. Exp. Med. 178:17.
6. Lefkovits, I., and H. Waldmann. 1984. Limiting dilution analysis of the cells of immune system. I. The clonal basis of the immune response. Immunol. Today. 5:262.
7. Tsudo, M., J. Kitamura, and M. Miyasaka. 1989. Characterization of the interleukin 2 receptor β chain using three distinct monoclonal antibodies. Proc. Natl. Acad. Sei. USA. 86:1982.
8. Smith, K.A. 1993. Lowest dose interleukin-2 immunotherapy. Blood. 81:1414.
9. 2+ and activation of PKC. J. Immunol. 142:1854.
10. Akbar, A.N., L. Terry, A. Timms, P. Beverley, and G. Janossy. 1988. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J. Immunol. 140:2171.
11. Byrne, J.A., J. Butler, and M.D. Cooper. 1988. Differential activation requirements for virgin and memory T cells. J. Immunol. 141:3249.
12. +) human T cells to multiple receptor-mediated stimuli but augmentation of responses by co-stimuli. Eur. J. Immunol. 20:1111.
13. Weaver, C.T., and E.R. Unanue. 1990. The costimulatory function of antigen presenting cells. Immunol. Today. 11:49.
14. Garman, R.D., K.A. Jacobs, S.T. Clark, and D.H. Raulet. 1987. B cell-stimulatory 2 (βi interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc. Natl. Acad. Sei. USA. 84:7629.
15. Scheurich, P., B. Thoma, U. Ucer, and K. Pfizenmaier. 1987. Immunoregulatory activity of recombinant human tumor necrosis factor TNFa: Induction of TNF receptors on human T cells and TNF-a-mediated enhancement of T cell responses. J. Immunol 138:1786.
16. Akbar, A.N., A. Timms, and G. Janossy. 1989. Cellular events during memory T cell activation in vitro: the UCHL1 determinant is newly synthesized after mitosis. Immunology. 66:213.
17. Sleasman, J.W., C. Morimoto, S.F. Schlosman, and T.F. Tedder. 1990. The role of functionally distinct helper T lymphocyte subpopulations in the induction of human B-cell differentiation. Eur. J. Immunol. 20:1357.
18. Shizuo, A., T. Hirano, T. Taga, and T. Kishimoto. 1990. Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB (Fed. Am. Soc. Exp Biol.) J. 4:2860.
19. Vink, A., C. Uyttenhove, P. Wauters, and J.V. Snick. 1990. Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor. Eur. J. Immunol. 20:1.
20. Depper, J.M., W.J. Leonard, C. Drogula, M. Krönke, T.A. Waldmann, and W.C. Greene. 1985. Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proc Natl. Acad. Sei. USA. 82:4230.
21. Owen-Schaub, L.B., W.L. Crump III, G.I. Morin, and E.A. Grimm. 1989. Regulation of lymphocyte tumor necrosis factor receptors by IL-2. J. Immunol, 143:2236.
22. Beverley, P. 1990. Is T cell memory maintained by crossreactive stimulation? Immunol. Today. 11:203.
23. Gray, D. 1993. Immunological memory: a function of antigen persistence. Trends in Microbiology. 1:39.
24. Bradley, L.M., M. Croft, and S.L. Swain. 1993. T cell memory: new perspectives. Immunol. Today. 14:197.