Segregation analysis of physician-diagnosed asthma in Hispanic and non- Hispanic white families: A recessive component?

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 1, 1996, Pages 144-150

  Holberg, Catharine J ^b   Elston, Robert C ^b   Halonen, Marilyn ^b   Wright, Anne L ^b   Taussig, Lynn M ^b   Morgan, Wayne J ^b   Martinez, Fernando D ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E;

ADULT; ALLELE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHILD; ETHNIC GROUP; FEMALE; GENE LOCUS; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RECESSIVE INHERITANCE; SEGREGATION ANALYSIS;

EID: 0030056158     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.154.1.8680670     Document Type: Article

References (37)

1. Sibbald, B., and M. Turner-Warwick. 1979. Factors influencing the prevalence of asthma among first degree relatives of extrinsic and intrinsic asthmatics. Thorax 34:322-337.
2. Duffy, D. L., N. G. Martin, D. Battistutta, J. L. Hoffer, and J. D. Mathews. 1990. Genetics of asthma and hayfever in Australian twins. Am. Rev. Respir. Dis. 142:1351-1358.
3. Elston, R. C. 1993. Genetic analysis of complex phenotypes: family studies of total IgE and bronchial hyperreactivity. In D. G. Marsh, A. Lockhart, and S. T. Holgate, editors. The Genetics of Asthma. Blackwell Scientific Publications, Oxford. Chapter 12.
4. Robertson, C. F., E. Heycock, J. Bishop, T. Nolan, A. Olinsky, and P. D. Phelan. 1991. Prevalence of asthma in Melbourne school children: changes over 26 years. B.M.J. 302:1116-1118.
5. Risch, N. 1991. Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genet. Epidemiol. 7:3-16.
6. Cookson, W. O .C. M., P. A. Sharp, J. A. Faux, and J. M. Hopkin. 1989. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet i: 1292-1295.
7. Shirakawa, T., L. Airong, M. Dubowitz, J. W. Dekker, A. E. Shaw, J. Faux, C. Ra, W. O. C. M. Cookson, and J. M. Hopkin. 1994. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat. Genet. 7:125-129.
8. Morton, N. E. 1990. Genetic linkage and complex diseases: a comment. Genet. Epidemiol. 7:33-34.
9. Taussig, L. M., A. L. Wright, W. J. Morgan, M. R. Harrison, C. G. Ray, and GHMA Pediatricians. 1989. The Tucson Children's Respiratory Study, I: design and implementation of a prospective study of acute and chronic respiratory illness in children. Am. J. Epidemiol. 129:1219-1231.
10. Elston, R. C., and V. T. George. 1989. Age of onset, age al examination, and other covariates in the analysis of family data. Genet. Epidemiol. 6:217-220.
11. Martinez, F. D., C. J. Holberg, M. Halonen, W. J. Morgan, A. L. Wright, and L. M. Taussig. 1994. Evidence for Mendelian inheritance of serum IgE in Hispanic and non-Hispanic white families. Am. J. Hum. Genet. 55:555-565.
12. Bonney, G. E. 1986. Regressive logistic models for familial disease and other binary traits. Biometrics 42:611-625.
13. S.A.G.E.: Statistical Analysis for Genetic Epidemiology, Release 2.1 and 2.2. Computer program package available from the Department of Epidemiology and Biostatistics. Case Western Reserve University School of Medicine, Cleveland, Ohio.
14. Go, R. C. P., R. C. Elston, and E. B. Kaplan. 1978. Efficiency and robustness of pedigree segregation analysis. Am. J. Hum. Genet. 30: 28-37.
15. Elston, R. C. 1980. Segregation analysis. In H. Harris and K. Hrischorn, editors. Advances in Human Genetics, Vol. 2. Plenum, New York. Chapter 2.
16. Self, S. G., and K. Y. Liang. 1987. Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. Journal of the American Statistical Association 82:605-610.
17. Maclean, C. J., N. E. Morton, and R. Lew. 1975. Analysis of family resemblance, IV: operational characteristics of segregation analysis. Am. J. Hum. Genet. 27:365-384.
18. Khoury, M. J., T. H. Beaty, and B. H. Cohen. 1993. Fundamentals of Genetic Epidemiology. Oxford University Press, New York. Chapter 8.
19. Bonney, G. E. 1984. On the statistical determination of major gene mechanisms in continuous human traits. Am. J. Med. Genet. 18:731-749.
20. Demenais, F. M., A. E. Laing, and G. E. Bonney. 1992. Numerical comparisons of two formulations of the logistic regressive models with the mixed model in segregation analysis of discrete traits. Genet. Epidemiol. 9:419-435.
21. Elston, R. C. 1993. Some recent developments in the theoretical aspects of segregation analysis. In P. P. Majurnder, editor. Human Population Genetics. Plenum Press, New York. 117-137.
22. Box, G. E. P., and D. R. Cox. 1964. An analysis of transformations (with discussion). J. R. Stat. Soc. 826:211-252.
23. Burrows, B., F. D. Martinez, M. Halonen, R. A. Barbee, and M. G. Cline. 1989. Association of asthma with serum IgE levels and skin test reactivity to allergens. N. Engl. J. Med. 320:271-277.
24. Marsh, D. G., W. B. Bias, and K. Ishizaka. 1974. Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. Proc. Natl. Acad. Sci. U.S.A. 71:3588-3592.
25. Meyers, D. A., T. H. Beaty, C. R. Coyler, and D. G. Marsh. 1991. Genetics of total serum IgE levels: a regressive model approach to segregation analysis. Genet. Epidemiol. 8:351-359.
26. Meyers, D. A., W. B. Bias, and D. G. Marsh. 1982. A genetic study of total IgE in the Amish. Hum. Hered. 32:15-23.
27. Hassedt, S. J., D. A. Meyers, and D. G. Marsh. 1983. Inheritance of immunoglobulin E: genetic model fitting. Am. J. Hum. Genet. 14:61-66.
28. Marsh, D. G., J. D. Neeley, D. R. Breazeale, B. Ghosh, L. R. Freidhoff, E. Ehrlich-Kautzky, C. Shou, G. Krishnaswamy, and T. H. Beaty. 1994. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264:1152-1156.
29. Meyers, D. A., D. S. Postma, C. I. Panhuysen, J. Xu, P. J. Amelung, R. C. Levitt, and E. R. Bleecker. 1994. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5q. Genomics 23:464-470.
30. Lockhart, A. 1993. What is bronchial asthma? The role of genetic and acquired factors. In D. G. Marsh, A. Lockhart, and S. T. Holgate, editors. The Genetics of Asthma. Blackwell Scientific Publications, Oxford. Chapter 1.
31. Longo, G., R. Strinati, F. Poli, and F. Fumi. 1987. Genetic factors in non-specific bronchial hyperreactivity: an epidemiologic study. Am. J. Dis. Child. 141:331-334.
32. Hopp, R. J., A. K. Bewtra, G. D. Watt, N. M. Nair. and R. G. Townley. 1984. Genetic analysis of allergic disease in twins. J. Allergy Clin. Immunol. 73:265-270.
33. Levitt, R. C., and W. Mitzner. 1989. Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine. J. Appl. Physiol. 67:1125-1132.
34. Townley, R. G., A. Bewtra, A. F. Wilson, R. J. Hopp, R. C. Elston, N. Nair, and G. D. Watt. 1986. Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma. J. Allergy Clin. Immunol. 77:101-107.
35. Marsh, D. G. 1988. Molecular studies of human immune recognition of allergens. Allergy 43(Suppl. 8):7-9.
36. Moffatt, M. F., M. R. Hill, F. Cornelis, C. Schou, and J. A. Faux. 1994. Genetic linkage of T-cell receptor alpha/delta complex to specific IgE responses. Lancet 343:1597-1600.
37. Holgate, S. T., W. M. Abraham, P. J. Barnes, and T. H. Lee. 1989. Pharmacology/treatment. In S.T. Holgate, editor. The Role of Inflammatory Processes in Airway Hyperresponsiveness. Blackwell Scientific Publications. Oxford. Chapter 6.