Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template

Biochemistry

Volumn 38, Issue 25, 1999, Pages 7969-7977

  Jhoti, Harren ^a   Cleasby, Anne ^a   Reid, Scott ^a,b   Thomas, Pam J ^a   Weir, Malcolm ^a   Wonacott, Alan ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Axys Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTONE; THROMBIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; COVALENT BOND; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; LACTONES; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPLATES, GENETIC; THROMBIN; TRITERPENES;

EID: 0033594929     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9830359     Document Type: Article

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