Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF- κB activation and apoptosis in rat striatum

Molecular Brain Research

Volumn 64, Issue 1, 1999, Pages 59-68

  Nakai, Masami ^a   Qin, Zheng Hong ^a   Wang, Yumei ^a   Chase, Thomas N ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

C Myc; Excitotoxicity; I B ; Neurodegeneration; NMDA receptor; Oxidative stress; p53

Indexed keywords

DOPAMINE 1 RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; N (7 HYDROXY 2,2,4,6 TETRAMETHYL 1 INDANYL) 4 (3 METHOXYPHENYL) 1 PIPERAZINEACETAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN P53; QUINOLINIC ACID; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; CORPUS STRIATUM; DNA FRAGMENTATION; DNA-BINDING PROTEINS; DRUG INTERACTIONS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, NEOPLASTIC; I-KAPPA B PROTEINS; INDANS; MALE; NERVE DEGENERATION; NEURONS; NEUROTOXINS; NF-KAPPA B; OXIDATIVE STRESS; PIPERAZINES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MYC; QUINOLINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033593608     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00310-6     Document Type: Article

References (64)

1. E. Aizeman, K.A. Hartnett, I.J. Reynolds, Oxygen free radicals regulate NMDA receptor function via a redox modulatory site, Neuron 5 (1990) 841-846.
2. T.J. Bazzett, J.B. Becker, K.W. Kaatz, R.L. Albin, Chronic intrastriatal dialytic administration of quinolinic acid produces selective neural degeneration, Exp. Neurol. 120 (1993) 177-185.
3. A.A. Beg, D. Baltimore, An essential role for NF-κB in preventing TNF-α-induced cell death, Science 274 (1996) 782-784.
4. E. Bonfoco, D. Krainc, M. Ankarcrona, P. Nicotera, S.A. Lipton, Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures, Proc. Natl. Acad. Sci. USA 92 (1995) 7162-7166.
5. P.A. Baeuerle, The inducible transcription activator NF-κB: regulation by distinct protein subunits, Biochem. Biophy. Acta 1072 (1991) 63-80.
6. D.W. Choi, Glutamate neurotoxicity and disease of the nervous system, Neuron 1 (1988) 623-634.
7. D.W. Choi, Excitotoxic cell death, J. Neurobiol. 23 (1992) 1261-1276.
8. J.A. Clemens, D.T. Stephenson, E.B. Smalstig, E.P. Dixon, S.P. Little, Global ischemia activates nuclear factor-κB in forebrain neurons of rats, Stroke 28 (1997) 1073-1081.
9. J.A. Clemens, D.T. Stephenson, T. Yin, E.B. Smalstig, J.A. Panetta, S.P. Little, Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-κB in rats, Stroke 29 (1998) 177-182.
10. D.B. Clifford, C.F. Zorumski, J.W. Olney, Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures, Exp. Neurol. 105 (1989) 272-279.
11. Y. Devary, R.A. Gottlieb, L.F. Lau, M. Karin, Rapid and preferential activation of the c-jun gene during the mammalian UV response, Mol. Cell. Biol. 11 (1991) 2804-2811.
12. Y. Du, K.R. Bales, R.C. Dodel, E. Hamilton-Byrd, J.W. Horn, D.L. Czilli, L.K. Simmons, B. Ni, S.M. Paul, Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons, Proc. Natl. Acad. Sci. USA 94 (1997) 11657-11662.
13. A.I. Faden, R.P. Simon, A potential role for excitotoxins in the pathophysiology of spinal cord injury, Ann. Neurol. 23 (1988) 623-626.
14. J. Garthwaite, Glutamate, nitric oxide and cell-cell signalling in the nervous system, Trends Neurosci. 14 (1991) 60-67.
15. E.J. Furshpan, D.D. Potter, Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture, Neuron 3 (1989) 199-207.
16. M. Gonzalez-Zulueta, L.M. Ensz, G. Mukhina, R.M. Lebovitz, R.M. Zwacka, J.F. Engelhardt, L.W. Oberley, V.L. Dawson, T.M. Dawson, Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity, J. Neurosci. 18 (1998) 2040-2055.
17. L.J.S. Greenlund, T.L. Deckwerth, E.M. Johnson Jr., Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death, Neuron 14 (1995) 303-315.
18. L. Guerrini, F. Blasi, S. Denis-Donini, Synaptic activation of NF-κB by glutamate in cerebellar granule neurons in vitro, Proc. Natl. Acad. Sci. USA 92 (1995) 9077-9081.
19. P.G. Gunasekar, A.G. Kanthasamy, J.L. Borowitz, G.E. Isom, NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death, J. Neurochem. 65 (1995) 2016-2021.
20. 2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents, J. Neurosci. 15 (1995) 5222-5237.
21. P.E. Hughes, T. Alexi, T. Yoshida, S.S. Schreiber, B. Knusel, Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53 inducible genes Bax and GADD-45 in brain areas showing DNA fragmentation, Neuroscience 74 (1996) 1143-1160.
22. S. Hunot, B. Brugg, D. Ricard, P.P. Michel, M.-P. Muriel, M. Ruberg, B.A. Faucheux, Y. Agid, E.C. Hirsch, Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease, Proc. Natl. Acad. Sci. USA 94 (1997) 7531-7536.
23. J. Jinno, H. Mori, Y. Oshiro, T. Kikuchi, H. Sakurai, Evaluation of superoxide scavenging activity of OPC-14117 by electron spin resonance technique, Free Rad. Res. Comms. 15 (1991) 223-230.
24. C. Kaltschmidt, B. Kaltschmidt, P. A Baeuerle, Stimulation of ionotropic glutamate receptors activates transcription factor NF-κB in primary neurons, Proc. Natl. Acad. Sci. USA 92 (1995) 9618-9622.
25. B. Kucukkaya, G. Haklar, A.S. Yalcin, NMDA excitotoxicity and free radical generation in rat brain homogenates: application of a chemiluminescence assay, Neurochem. Res. 21 (1996) 1535-1538.
26. C. Kretz-Remy, P. Mehlen, M.-E. Mirault, A-P. Arrigo, Inhibition of IκBα phosphorylation and degradation and subsequent NF-κB activation by glutathione peroxidase overexpression, J. Cell. Biol. 133 (1996) 1083-1093.
27. M. Lafon-Cazal, S. Pietri, M. Culcasi, J. Bockaert, NMDA-dependent superoxide production and neurotoxicity, Nature 364 (1993) 535-537.
28. G.B. Landwehrmeyer, D.G. Standaert, C.M. Testa, J.B. Penney Jr., A.B. Young, NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum, J. Neurosci. 15 (1995) 5297-5307.
29. M. Levivier, S. Holemans, D.M. Togasaki, J.-M. Maloteaux, J. Brotchi, S. Przedborski, Quantitative assessment of quinolinic acid-induced striatal toxicity in rats using radioligand binding assays, Neurol. Res. 16 (1994) 194-201.
30. Y. Li, M. Chopp, Z.G. Zhang, C. Zaloga, L. Niewenhuis, S. Gautam, p53 Immunoreactivity protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats, Stroke 25 (1994) 849-856.
31. K.-I. Lin, S.-W. Lee, R. Narayanan, J.M. Baraban, J.M. Hardwick, Thiol agents and Bcl-2 identify an alphavirus-induced apoptosis pathway that requires activation of the transcription factor NF-κB, J. Cell. Biol. 131 (1995) 1149-1161.
32. S.A. Lipton, P.A. Rosenberg, Mechanisms of disease: excitatory amino acids as a final common pathway for neurologic disorders, N. Engl. J. Med. 330 (1994) 613-622.
33. S.A. Lipton, Janus faces of NF-κB: neurodestruction vs. neuroprotection, Nature Med. 3 (1997) 20-22.
34. P.G. Lysko, K.A. Lysko, T.-L. Yue, C.L. Webb, J.-L. Gu, G. Feuerstein, Neuroprotective effects of carvedilol, a new antihypertensive agent, in cultured rat cerebellar neurons and in gerbil global brain ischemia, Stroke 23 (1992) 1630-1636.
35. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor, EMBO J. 12 (1993) 2005-2015.
36. H. Monyer, D.M. Hartley, D.W. Choi, 21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures, Neuron 5 (1990) 121-126.
37. T. Nakagomi, A. Asai, H. Kanemitsu, K. Narita, Y. Kuchino, A. Tamura, T. Kirini, Up-regulation of c-myc gene expression following focal ischemia in the rat brain, Neurol. Res. 18 (1996) 559-563.
38. J.W. Olney, Excitotoxicity and N-methyl-D-aspartate receptors, Drug Dev. Res. 17 (1989) 299-319.
39. Y. Oshiro, Y. Sakurai, T. Tanaka, T. Kikuchi, T. Hirose, K. Tottori, Novel cerebroprotective agents with central nervous system stimulating activity: 2. Synthesis and pharmacology of the 1-(acylamino)-7-hydroxyindan derivatives, J. Med. Chem. 34 (1991) 2014-2023.
40. R.N. Pittman, S. Wang, A.J. DiBenedetto, J.C. Mills, A system for characterizing cellular and molecular events in programmed neuronal cell death, J. Neurosci. 13 (1993) 3669-3680.
41. C. Portera-Cailliau, J.C. Hedreen, D.L. Price, V.E. Koliatsos, Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models, J. Neurosci. 15 (1995) 3775-3787.
42. 2 dopamine receptors, J. Neurochem. 62 (1994) 411-420.
43. Z.-H. Qin, S.-P. Zhang, B. Weiss, Dopaminergic and glutamatergic blocking drugs differentially regulate gene expression of glutamic acid decarboxylase in mouse brain, Mol. Brain Res. 21 (1994) 293-302.
44. Z.-H. Qin, Y. Wang, T.N. Chase, Stimulation of N-methyl-D-aspartate receptors induces apoptosis in rat brain, Brain Res. 725 (1996) 166-177.
45. Z.-H. Qin, Y. Wang, M. Nakai, T.N. Chase, Nuclear factor-κB contributes to excitotoxin-induced apoptosis in rat striatum, Mol. Pharmacol. 53 (1998) 33-42.
46. Z.-H. Qin, R.-W. Chen, Y. Wang, M. Nakai, D.-M. Chuang, T.N. Chase, NF-κB nuclear translocation upregulates c-Myc and p53 expression during N-methyl-D-aspartate receptor-induced apoptosis in rat striatum, 1998, in preparation.
47. A. Rattner, M. Korner, M.D. Walker, Y. Citri, NF-κB activates the HIV promotor in neurons, EMBO J. 12 (1993) 4261-4267.
48. I.J. Reynolds, T.G. Hastings, Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation, J. Neurosci. 15 (1995) 3318-3327.
49. S.M. Rothman, Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death, J. Neurosci. 4 (1984) 1884-1891.
50. J.C. Saez, J.A. Kessler, M.V.L. Bennett, D.C. Spray, Superoxide dismutase protects cultured neurons against death by starvation, Proc. Natl. Acad. Sci. USA 84 (1987) 3056-3059.
51. R. Schreck, P. Rieber, P.A. Baeuerle, Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1, EMBO J. 10 (1991) 2247-2258.
52. R. Schreck, K. Albermann, P.A. Baeuerle, Nuclear factor κB: an oxidative stress responsive transcription factor of eukaryotic cells (a review), Free Rad. Res. Comms. 17 (1992) 221-237.
53. R.P. Simon, J.H. Swan, T. Griffiths, B.S. Meldrum, Blockade of N-methyl-D-aspartate receptors may protect against ischemia damage in the brain, Science 226 (1984) 850-852.
54. F.J. Staal, M. Roederer, L.A. Herzenberg, Intracellular thiols regulate activation of nuclear factor KB and transcription of human immunodeficiency virus, Proc. Natl. Acad. Sci. USA 87 (1990) 9943-9947.
55. 2+-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis, J. Biol. Chem. 269 (1994) 14857-14860.
56. E.S. Tecoma, H. Monyer, M.P. Goldberg, D.W. Choi, Traumatic neuronal injury in vitro is attenuated by NMDA antagonists, Neuron 2 (1989) 1541-1545.
57. K. Terai, A. Matsuo, P.L. Mcgeer, Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease, Brain Res. 735 (1996) 159-168.
58. D. Thanos, T. Maniatis, NF-κB: a lesson in family values, Cell 80 (1995) 529-532.
59. C.B. Thompson, Apoptosis in the pathogenesis and treatment of disease, Science 267 (1995) 1456-1462.
60. C.M. Troy, M.L. Shelanski, Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells, Proc. Natl. Acad. Sci. USA 91 (1994) 6384-6387.
61. Y. Wang, Z.-H. Qin, M. Nakai, T.N. Chase, Glutamate metabotropic receptor agonist 1S,R-ACPD induces internucleosomal DNA fragmentation and cell death in rat striatum, Brain Res. 772 (1997) 45-56.
62. J. Weiss, M.P. Goldberg, D.W. Choi, Ketamine protects cultured neocortical neurons from hypoxic injury, Brain Res. 280 (1986) 186-190.
63. T. Wieloch, Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist, Science 230 (1985) 681-683.
64. C.S. Yang, P.J. Tsai, N.N. Lin, J.S. Kuo, Elevated extracellular glutamate concentrations increased malondialdehyde production in anesthetized rat brain cortex, Neurosci Lett. 243 (1998) 33-36.