Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons

Neuroscience Letters

Volumn 231, Issue 1, 1997, Pages 33-36

  Kirschstein, T ^a   Busselberg D ^b   Treede, R D ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Capsaicin; Heat pain; Patch clamp; Primary sensory neurons

Indexed keywords

CAPSAICIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEAT SENSATION; HEAT SENSITIVITY; MEMBRANE CURRENT; NERVE CELL MEMBRANE; NOCICEPTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; CAPSAICIN; CELL SIZE; GANGLIA, SPINAL; HEAT; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 0343924358     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00533-8     Document Type: Article

References (15)

1. Baumann, T.K. and Martenson, M.E., Thermosensitivity of cultured trigeminal neurons, Soc. Neurosci. Abstr., 20 (1994) 1379.
2. Baumann, T.K., Simone, D.A., Shain, C.N. and LaMotte, R.H., Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia, J. Neurophysiol., 66 (1991) 212-227.
3. Blenk, K.-H., Michaelis, M., Vogel, C. and Jänig, W., Thermosensitivity of acutely axotomized sensory nerve fibers, J. Neurophysiol., 76 (1996) 743-752.
4. 2 laser stimuli causing pain, Exp. Brain Res., 55 (1984) 158-166.
5. Cesare, P. and McNaughton, P., A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin, Proc. Natl. Acad. Sci. USA, 93 (1996) 15435-15439.
6. Gold, M.S., Dastmalchi, S. and Levine, J.D., Co-expression of nociceptor properties in dorsal root ganglion neurons from the adult rat in vitro, Neuroscience, 71 (1996) 265-275.
7. Holzer, P., Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons, Pharmacol. Rev., 43 (1991) 143-201.
8. Kirschstein, T., Büsselberg, D. and Treede, R.-D., Noxious heat activates an inward current in a subpopulation of dorsal root ganglion neurones, Pflügers Arch. (Suppl.), 433 (1997) R60 (Abstract).
9. Koschorke, G.M., Meyer, R.A., Tillman, D.B. and Campbell, J.N., Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli, J. Neurophysiol., 65 (1991) 693-701.
10. Kress, M., Koltzenburg, M., Reeh, P.W. and Handwerker, H.O., Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro, J. Neurophysiol., 68 (1992) 581-595.
11. Petersen, M., LaMotte, R.H., Klusch, A. and Kniffki, K.D., Multiple capsaicin-evoked currents in isolated rat sensory neurons, Neuroscience, 75 (1996) 495-505.
12. Szolcsányi, J., Anton, F., Reeh, P.W. and Handwerker, H.O., Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin, Brain Res., 446 (1988) 262-268.
13. Treede, R.-D., Meyer, R.A., Raja, S.N. and Campbell, J.N., Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin, J. Physiol., 483 (1995) 747-758.
14. von Banchet, G.S., Petersen, M. and Heppelmann, B., Bradykinin receptors in cultured rat dorsal root ganglion cells: influence of length of time in culture, Neuroscience, 75 (1996) 1211-1218.
15. Vyklicky, L. and Knotková-Urbancová, H., Can sensory neurones in culture serve as a model of nociception?, Physiol. Res., 45 (1996) 1-9.