Functional characterization of the human platelet glycoprotein V gene promoter: A specific marker of late megakaryocytic differentiation

Blood

Volumn 94, Issue 10, 1999, Pages 3366-3380

  Lepage, Adeline ^b   Uzan, Georges ^b   Touche, Nadège ^b   Morales, Martine ^b   Cazenave, Jean Pierre ^b   Lanza, François ^b   De La Salle, Corinne ^a  

^a INSERM   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; THROMBIN; THROMBOCYTE FACTOR 5; VON WILLEBRAND FACTOR;

APOPTOSIS; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL MATURATION; GENE DELETION; GENE REPRESSION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TANDEM REPEAT; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

EID: 0033571252     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.10.3366.422k35_3366_3380     Document Type: Article

References (79)

1. Romeo P-H, Prandini M-H, Joulin V, Prenant M, Vainchenker W, Marguerie G, Uzan G: Megakaryocytic and erythrocytic lineages share specific transcription factors. Nature 344:447, 1990
2. Martin DI, Zon LI, Mutter G, Orkin SH: Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature 344:444, 1990
3. Mouthon M-A, Bernard O, Mitjavila M-T, Romeo P-H, Vainchenker W, Mathieu-Mahul D: Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81:647, 1993
4. Shivdasani RA, Mayer E, Orkin SH: Absence of blood formation in mice lacking the T-cell leukemia oncoprotein tal-1/SCL. Nature 373:432, 1995
5. Hashimoto Y, Ware J: Identification of essential GATA and Ets binding motifs within the promoter of the platelet glycoprotein Ibα gene. J Biol Chem 270:24532, 1995
6. Ravid K, Doi T, Beeler D, Kuter D, Rosenberg R: Transcriptional regulation of the rat platelet factor 4 gene: Interaction between an enhancer/silencer domain and the GATA site. Mol Cell Biol 11:6116, 1991
7. Martin F, Prandini M-H, Thevenon D, Marguerie G, Uzan G: The transcription factor GATA-1 regulates the promoter activity of the platelet glycoprotein IIb gene. J Biol Chem 268:21606, 1993
8. Bastian LS, Yagi M, Chan C, Roth G: Analysis of the megakaryocyte glycoprotein IX promoter identifies positive and negative regulatory domains and functional GATA and Ets sites. J Biol Chem 271:18554, 1996
9. Ludlow L, Schick B, Budarf M, Driscoll D, Zackai E, Cohen A, Konkle B: Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibβ promoter resulting in the Bernard-Soulier syndrome. J Biol Chem 271:22076, 1996
10. Visvader J, Adams JM: Megakaryocytic differentiation induced in 416B myeloid cells by GATA-2 and GATA-3 transgenes or 5-azacytidine is tightly coupled to GATA-1 expression. Blood 82:1493, 1993
11. Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Constantini F: Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcriptional factor GATA-1. Nature 349:257, 1991
12. Pevny L, Lin C-S, D'Agati V, Simon MC, Orkin SH, Constantini F: Development of hematopoietic cells lacking transcription factor GATA-1. Development 121:163, 1995
13. Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH: Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci USA 93: 12355, 1996
14. Weiss MJ, Orkin SH: Transcriptional factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci USA 92:9623, 1995
15. Shivdasani RA, Fujiwara Y, Mac Devitt MA, Orkin SH: A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 16:3965, 1997
16. Weiss MJ, Orkin SH: GATA transcription factors: Key regulators of hematopoiesis. Exp Hematol 23:99, 1995
17. Takahashi S, Komeno T, Suwabe N, Yoh K, Nakajima O, Nishimura S, Kuroha T, Nagasawa T, Yamamoto M: Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo. Blood 92:434, 1998
18. Wall L, deBoer E, Grosveld F: The human beta-globin gene 3′ enhancer contains multiple binding sites for an erythroid specific protein. Genes Dev 2:1089, 1988
19. Talbot D, Grosveld F: The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally active distinct NF-E2 binding sites. EMBO J 10:1391, 1991
20. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJM, Orkin SH: Transcription factor NF-E2 is required for platelet formation independent of the action of thrombopoietin/MGDF in megakaryocyte development. Cell 81:695, 1995
21. Lecine P, Villeval JL, Vyas P, Swencki B, Xu Y, Shivdasani RA: Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood 92:1608, 1998
22. Kobayashi S, Teramura M, Ito K, Iwabe K, Inaba T, Mizoguchi H: Transcription factor NF-E2 is essential for the polyploidization of a human megakaryoblastic cell line, Meg-J. Biochem Biophys Res Commun 247:65, 1998
23. Doubeikovski A, Uzan G, Doubeikovski Z, Prandini M-H, Porteu F, Gisselbrecht S, Dusanter-Fourt I: Thrombopoietin-induced expression of the glycoprotein IIb gene involves the transcription factor PU.1/Spi-1 in UT7-Mpl cells. J Biol Chem 272:24300, 1997
24. Zhang C, Gadue P, Scott E, Atchison M, Poncz M: Activation of the megakaryocyte-specific gene platelet basic protein (PBP) by the Ets family factor PU.1. J Biol Chem 272:26236, 1997
25. Moreau-Gachelin F, Wendling F, Molina T, Denis N, Titeux M, Grimber G, Briand P, Vainchenker W, Tativian A: Spi-1/PU.1 transgenic mice develop multistep erythroleukemia. Mol Cell Biol 16:2453, 1996
26. Yamada T, Kihara-Negishi F, Yamamoto H, Yamamoto M, Hashimoto Y, Oikawa T: Reduction of DNA binding activity of the GATA-1 transcription factor in the apoptotic process induced by overexpression of PU.1 in murine erythroleukemia cells. Exp Cell Res 245:186, 1998
27. Athanassiou M, Clausen PA, Mavrothalassitis GJ, Zhang XK, Watson DK, Blair DG: Increased expression of the ETS-related transcription factor Fli-1/ERGB correlates with and can induce the megakaryocytic phenotype. Cell Growth Differ 7:1525, 1996
28. Kwiatkowski B, Bastian L, Bauer T, Tsai S, Zielinska-Kwiatkowski A, Hickstein D: The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity. J Biol Chem 273:17525, 1998
29. Uzan G, Prenant M, Prandini M-H, Martin F, Marguerie G: Tissue-specific expression of the platelet GPIIb gene. J Biol Chem 266:8932, 1991
30. Prandini M-H, Uzan G, Martin F, Thevenon D, Marguerie G: Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein lib promoter. J Biol Chem 267:10370, 1992
31. Prandini M-H, Martin F, Thevenon D, Uzan G: The tissue-specific transcriptional regulation of the megakaryocytic glycoprotein IIb gene is controlled by interactions between a repressor and positive cis-acting elements. Blood 88:2062, 1996
32. alt. Blood 76:336, 1990
33. Ramachandran B, Surrey S, Schwartz E: Megakaryocyte-specific positive regulatory sequence 5′ to the human PF4 gene. Exp Hematol 23:49, 1995
34. Deveaux S, Filipe A, Lemarchandel V, Ghysdael J, Romeo P-H, Mignotte V: Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Blood 87:4678, 1996
35. Majumdar S, Gonder D, Koutsis B, Poncz M: Characterization of the human β-thromboglobulin gene. Comparison with the gene for platelet factor 4. J Biol Chem 266:5785, 1991
36. Sakariassen KS, Bolhuis PA, Sixma JJ: Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-von Willebrand factor bound to the subendothelium. Nature 279:636, 1979
37. Lopez J: The platelet glycoprotein Ib-IX complex. Blood Coagul Fibrinol 5:97, 1994
38. Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AEGK: Glycoprotein V and Ib-IX form a noncovalent complex in the platelet membrane. J Biol Chem 267:364, 1992
39. Roth GJ: Developing relationships: Arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins. Blood 77:5, 1991
40. Wicki AN, Clemetson KJ: Structure and function of platelet membrane glycoproteins Ib and V. Eur J Biochem 153:1, 1985
41. Handa M, Titani K, Holland LZ, Roberts JR, Ruggeri ZM: The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. J Biol Chem 261:12579, 1986
42. Wenger RH, Kieffer N, Wicki AN, Clemetson KJ: Structure of the human blood platelet membrane glycoprotein Ibα gene. Biochem Biophys Res Commun 156:389, 1988
43. Hickey MJ, Roth GJ: Characterization of the gene encoding the human platelet GPIX. J Biol Chem 268:3438, 1993
44. Debili N, Issad C, Masse J-M, Guichard J, Katz A, Breton-Gorius J, Vainchenker W: Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation. Blood 80:3022, 1992
45. Lanza F, Morales M, de la Salle C, Cazenave J-P, Clemetson KJ, Shimomura T, Phillips DR: Cloning and characterization of the gene encoding the human platelet glycoprotein V: A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. J Biol Chem 270:20801, 1993
46. Orkin SH: Transcription factors and hematopoietic development. J Biol Chem 270:4955, 1995
47. Lemarchandel V, Ghysdael J, Mignotte V, Rahuel C, Romeo P-H: GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression. Mol Cell Biol 13:668, 1993
48. Uzan G, Prandini M-H, Berthier R: Regulation of gene transcription during the differentiation of megakaryocytes. Thromb Haemost 74:210, 1995
49. Ravanat C, Morales M, Azorsa D, Moog S, Schuler S, Grunert P, Loew D, van Dorsselaer A, Cazenave J-P, Lanza F: Gene cloning of rat and mouse platelet glycoprotein V: Identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Blood 89:3253, 1997
50. Tronik-Le Roux D, Roullot V, Schweitzer A, Berthier R, Marguerie G: Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein αIIb promoter. J Exp Med 181:2141, 1995
51. Mignotte V, Vigon I, Boucher de Crevecoeur E, Romeo P-H, Lemarchandel V, Chretien S: Structure and transcription of the human c-mpl gene (MPL). Genomics 20:5, 1994
52. Greenberg SM, Rosenthal DS, Greely TA, Tantravahi R, Handin RI: Characterization of a new megakaryocyte cell line: The Dami cell. Blood 72:1968, 1988
53. MacLeod RAF, Dirks WG, Reid YA, Hay RJ, Drexler HG: Identity of original and late passage Dami megakaryocytes with HEL erythroleukemia cells shown by combined cytogenetics and DNA fingerprinting. Leukemia 11:2032, 1997
54. Azorsa D, Moog S, Ravanat C, Schuhler S, Folléa G, Cazenave J-P, Lanza F: Measurement of GPV released by activated platelets using a sensitive immunocapture ELISA; its use to follow platelet storage in transfusion. Thromb Haemost 81:131, 1999
55. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
56. Dignam JD, Lebovitz RM, Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475, 1983
57. Ohlsson H, Edlung T: Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell 45:35, 1986
58. Seigneurin D, Champelorier P, Mouchiroud G, Berthier R, Leroux D, Prenant M, McGregor J, Starck J, Morle F, Micoin C, Pietrantuono A, Kolodie L: Human chronic myeloid leukemic cell line with positive Philadelphia chromosome exhibits megakaryocytic and erythroid characteristics. Exp Hematol 15:822, 1987
59. Martin P, Papayannopoulou T: HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression. Science 216:1233, 1982
60. 2 integrin promoter: Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression. J Biol Chem 269:463, 1994
61. Doi T, Greenberg SH, Rosenberg RD: Structure of the rat platelet factor 4 gene: A marker for megakaryocyte differentiation. Mol Cell Biol 7:898, 1987
62. Smale ST, Baltimore D: The "Initiator" as a transcription control element. Cell 57:103, 1989
63. Merika M, Orkin SH: DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 13:3999, 1993
64. Wasylyk B, Hahn L, Giovane A: The ETS family of transcription factors. Eur J Biochem 211:7, 1993
65. Kageyama R, Merlino GT, Pastan I: Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box. J Biol Chem 264:15508, 1989
66. Darnell JE: STATs and gene regulation. Science 277:1630, 1997
67. Yagi M, Edelhoff S, Disteche C, Roth G: Human platelet glycoproteins V and IX: Mapping of two leucine-rich glycoproteins genes to chromosome 3 and analysis of structures. Biochemistry 34:16132, 1995
68. Mignotte V, Lemarchandel V, Romeo P-H: GATA et Ets: Deux familles de déterminants majeurs de la différenciation hématopoïétique. Hématologie 1:19, 1995
69. IIb, integrin gene expression during megakaryocytic differentiation of K562 cells. Role of a silencer element. J Biol Chem 269:18441, 1994
70. 3 integrin gene. Blood 83:668, 1994
71. IIb, gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene. Blood 88:2071, 1996
72. Miyakawa Y, Oda A, Druker BJ, Miyazaki H, Handa M, Ohashi H, Ikeda Y: Thrombopoietin induces tyrosine phophorylation of STAT-3 and STAT-5 in human blood platelets. Blood 87:439, 1996
73. Drachman JG, Sabath DF, Fox NE, Kaushansky K: Thrombopoietin signal transduction in purified murine megakaryocytes. Blood 89:483, 1997
74. Pan J, McEver RP: Characterization of the promoter for the human P-selectin gene. J Biol Chem 268:22600, 1993
75. Breton-Gorius J, Favier R, Guichard J, Cherif D, Berger R, Debili N, Vainchenker W, Douay L: A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelets, alpha-granules, and chromosome 11 deletion at 11q23. Blood 85:1805, 1995
76. Shivdasani RA, Orkin SH: The transcriptional control of hematopoiesis. Blood 87:4025, 1996
77. Schuetze S, Paul R, Gliniak BC, Kabat D: Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells. Mol Cell Biol 12:2967, 1992
78. Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113, 1990
79. Stark J, Doubeikovski A, Sarrazin S, Gonnet C, Rao G, Skoultchi A, Godet J, Dusanter-Fourt I, Morle F: Spi-1/PU.1 is a positive regulator of the fli-1 gene involved in inhibition of erythroid differentiation in Friend erythroleukemic cell lines. Mol Cell Biol 19:121, 1999