Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries

Japanese Journal of Pharmacology

Volumn 72, Issue 1, 1996, Pages 57-65

  Egashira, Toru ^a   Takayama, Fusako ^a   Yamanaka, Yasumitsu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Aged rat; Aniracetam; Bifemelane; Choline acetyltransferase; Muscarinic receptor; Permanent bilateral occlusion of common carotid arteries

Indexed keywords

ANIRACETAM; BIFEMELANE; BRAIN ENZYME; CHOLINE ACETYLTRANSFERASE; MUSCARINIC RECEPTOR; QUINUCLIDINYL BENZILATE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; CORPUS STRIATUM; DISSOCIATION CONSTANT; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0029950466     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.72.57     Document Type: Article

References (32)

1. Ogawa N, Mizukawa K and Sora I: Chronic dihydroergotoxine administration increases muscarinic cholinergic receptor binding in aged-rat brain. Res Commun Chem Pathol Pharmacol 57, 149-160 (1987)
2. Tobe A, Egawa M and Nagai R: Effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) on the scopolamine-induced deficit of spontaneous alternation behavior in rats. Jpn J Pharmacol 33, 775-784 (1983)
3. Kakihana M, Yamazaki N and Nagaoka A: Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia. Jpn J Pharmacol 36, 357-363 (1984)
4. Stefanovich V: Effects of propentofylline on cerebral metabolism of rats. Drug Dev Res 6, 327-338 (1985)
5. Yamada K, Inoue T, Tanaka M and Furukawa T: Prolongation of latencies for passive avoidance responses in rats treated with aniracetam or piracetam. Pharmacol Biochem Behav 22, 645-648 (1985)
6. 1 agonist, on the impaired working memory in AF64A-treated rats. Jpn J Pharmacol 51, 539-547 (1989)
7. Sugaya K, Takahashi M and Kubota K: Cholecystokinin protects cholinergic neurons against basal forebrain lesion. Jpn J Pharmacol 59, 125-128 (1992)
8. Takahashi M, Sugaya K and Kubota K: Kangenkaryu prevents the decrease of cholinergic markers following the nucleus basalis magnocellularis lesion. Jpn J Pharmacol 60, 307-310 (1992)
9. Egashira T, Nagai T, Kimba Y, Takano R and Yamanaka Y: Effects of bifemelane hydrochloride on various cholinergic markers in cortical and subcortical regions of aged rats. Jpn J Pharmacol 51, 211-218 (1989)
10. Yufu F, Egashira T and Yamanaka Y: Age-related changes of cholinergic markers in the rat brain. Jpn J Pharmacol 66, 247-255 (1994)
11. Chui HC: Dementia: A review emphasizing clinicopathologic correlation and brain-behavior relationships. Arch Neurol 46, 806-814 (1989)
12. Barclay LL, Zemcov A, Blass JP and Sansone J: Survival in Alzheimer's disease and vascular dementias. Neurology 35, 834-840 (1985)
13. Ni JW, Matsumoto K and Watanabe H: Tetramethylpyrazine improves spatial cognitive impairment induced by permanent occlusion of bilateral common carotid arteries or scopolamine in rats. Jpn J Pharmacol 67, 137-141 (1995)
14. Pulsinelli WA and Brierley JB: A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10, 267-272 (1979)
15. Ni JW, Matsumoto K and Watanabe H: Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats. Brain Res 653, 231-236 (1994)
16. Nakajima T, Takahashi M and Okada T: Pharmacological study of aniracetam 〈VI〉 Effects of aniracetam on muscarinic acetylcholine receptors in the rat hippocampus. Jpn Pharmacol Ther 14, 751-757 (1986) (Abstr in English)
17. Yamamura HI and Snyder SH: Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci USA 71, 1725-1729 (1974)
18. Fonnum F: A rapid radiochemical method for determination of choline acetyltransferase. J Neurochem 24, 407-409 (1975)
19. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with Folin phenol reagent. J Biol Chem 193, 265-275 (1951)
20. Saito K, Honda S, Tobe A and Yanagiya I: Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and Mongolian gerbils. Jpn J Pharmacol 38, 375-380 (1985)
21. Tobe A, Egawa M, Saito K and Hashimoto N: Effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016, bifemelane hydrochloride) on spontaneous motor activity under different experimental conditions. Folia Pharmacol Jpn 86, 51-60 (1985) (Abstr in English)
22. 1-muscarinic agonist. Jpn J Pharmacol 55, 177-180 (1991)
23. Reisine TD, Yamamura HI, Bird ED, Spokes E and Enna SJ: Pre- and postsynaptic neurochemical alterations of Alzheimer's disease. Brain Res 159, 477-481 (1978)
24. Henke H and Lang W: Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients. Brain Res 267, 281-291 (1983)
25. Etienne P, Robitaile Y, Wood P, Gauthier S, Nair NPV and Quirion R: Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease. Neuroscience 19, 1279-1291 (1986)
26. Nakahiro M, Fukuchi I, Uchida S and Yoshida H: The "antidementic drug", pantoyl-GABA, increase choline acetyltransferase activity in mouse brain. Jpn J Pharmacol 49, 407-411 (1989)
27. Egashira T, Sudo S, Yufu F, Kono T, Kudo Y, Goto S, Takayama F and Yamanaka Y: Effects of bifemelane hydrochloride on various cholinergic markers in brain of aged rats. Comparison with biochemical actions of cholinergic markers of some cerebral metabolic enhancers. Clin Report 25, 2661-2674 (1991) (Abstr in English)
28. Scremin OU and Jenden DJ: Effects of middle cerebral artery occlusion on cerebral cortex choline and acetylcholine in rats. Stroke 20, 1524-1530 (1989)
29. Newman GC, Hospod FE and Wu P: Thick brain slices model the ischemic penumbra. J Cereb Blood Flow Metab 8, 586-597 (1988)
30. Inokuchi T, Hirano T, Kano A, Egawa M, Iida S and Tobe A: Effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane hydrochloride MCI-2016,) on cerebral glucose metabolism. Folia Pharmacol Jpn 86, 425-431 (1985) (Abstr in English)
31. Okada T, Satoh T and Yajima T: Pharmacological study of aniracetam 〈VI〉 A protective effect of aniracetam on decrease in deoxyglucose uptake in the rat brain under anemic hypoxia. Jpn Pharmacol Ther 14, 733-740 (1986)
32. Pedata F, Moroni F and Pepeu GC: Effect of nootropic agents on brain cholinergic mechanism. Clin Neuropharmacol 7, 772-773 (1984)