Age-related deficits in the cerebellar beta adrenergic signal transduction cascade in Fischer 344 rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 2, 1997, Pages 965-971

  Gould, Thomas J ^a   Bickford, Paula C ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7BETA DECACETYL 7BETA(GAMMA N METHYLPIPERAZINO)BUTYRYLFORSKOLIN; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CELL AGING; ENZYME ACTIVATION; GABAERGIC TRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PURKINJE CELL; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AGING; ANIMALS; CEREBELLUM; CYCLIC AMP; FORSKOLIN; GAMMA-AMINOBUTYRIC ACID; MALE; RATS; RATS, INBRED F344; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION;

EID: 0030926219     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. ARAKI, T., KATO, H., FUJIWARA, T. AND ITOYAMA, Y.: Age-related changes in binding of second messengers in the rat brain. Brain Res. 704: 227-232, 1995.
2. BERG, A. AND ZIMMERMAN, I. D.: Effects of electrical stimulation and norepinephrine on cyclic-AMP levels in the cerebral cortex of the aging rat. Mech. Ageing Dev. 4: 377-383, 1975.
3. BICKFORD, P.: Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function. Brain Res. 620: 133-138, 1993.
4. BICKFORD, P., HERON, C., YOUNG, D. A., GERHARDT, G. A. AND D. E. L. A. GARZA, R.: Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats. Neurobiol. Aging 13: 475-481, 1992.
5. A receptor function on cerebellar Purkinje cells Soc. Neurosci. Abstr. 17: 602, 1991.
6. A receptor-activated current by norepinephrine in cerebellar Purkinje cells. Neuroscience 51: 951-960, 1992.
7. ECCLES, J. C., ITO, M. AND SZENTOGOTHAI, J.: The Cerebellum as a Neuronal Machine, Springer, New York, 1967.
8. FREEDMAN, R., HOFFER, B. J. AND WOODWARD, D. J.: A quantitative microiontophoretic analysis of the responses of central neurones to noradrenaline: Interactions with cobalt, manganese, verapamil and dichloroisoprenaline. Br. J. Pharmacol. 54: 529-539, 1975.
9. GIORGI, M., SQUITTI, R., BONSI, P., PAGGI, P. AND TOSCHI, G.: Activities of 3′:5′-cyclic nucleotide phosphodiesterase in the superior cervical ganglion of rat: Characterization, compartmentalization and observations in young and old animals. Neurochem. Int. 25: 493-500, 1994.
10. GOULD, T. J. AND BICKFORD, P. C.: The effects of chronic treatment with N-tertbutyl-α-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats. Brain Res. 660: 333-336, 1994.
11. GOULD, T. J., BOWENKAMP, K. E., LARSON, G., ZAHNISER, N. R. AND BICKFORD, P. C.: Effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged F344 rats. Brain Res. 684: 150-158, 1995.
12. GOVONI, S., RIUS, R. A., BATTAINI, F. AND TRABUCCHI, M.: Reduced cAMP-dependent phosphorylation in striatum and nucleus accumbens of aged rats: Evidence of an altered functioning of D1 dopaminoceptive neurons. J. Gerontol. 43: B93-B97, 1988.
13. HARA, H., ONODERA, H., KATO, H. AND KOGURE, K.: Effects of aging on signal transmission and transduction systems in the gerbil brain: Morphological and autoradiographic study. Neuroscience 475-488, 1992.
14. A receptor phosphorylation: Multiple sites, actions and artifacts. Trends Pharmacol. Sci. 12: 84-87, 1991a.
15. A receptor-mediated C1 uptake by brain microsacs. J. Neurochem. 57: 722-725, 1991b.
16. LIN, A. M.-Y., BICKFORD, P. C. AND PALMER, M. R.: The effects of ethanol on γ-aminobutyric acid-induced depressions of cerebellar Purkinje neurons: Influence of beta adrenergic receptor action in young and aged Fischer 344 rats. J. Pharmacol. Exp. Ther. 264: 951-957, 1993.
17. MAGGI, A., SCHMIDT, M. J., GHETTI, B. AND ENNA, S. J.: Effect of aging on neurotransmitter receptor binding in rat and human brain. Life Sci. 24: 367-374, 1979.
18. MARWAHA, J., HOFFER, B. J. AND FREEDMAN, R.: Changes in noradrenergic neurotransmission in rat cerebellum during aging. Neurobiol. Aging 2: 95-98, 1981.
19. MCINTOSH, H. H. AND WESTFALL, T. C.: Influence of aging on catecholamine levels, accumulation, and release in F-344 rats. Neurobiol. Aging 8: 233-239, 1987.
20. MEWES, T., DUTZ, S., RAVENS, U. AND JAKOBS, K. H.: Activation of calcium currents in cardiac myocytes by empty β-adrenoceptors. Circulation 88: 2916-2922, 1993.
21. 125I-pindolol binding in Fischer 344 rat brain: Changes in beta-adrenergic receptor density with aging. Neurobiol. Aging 9: 267-272, 1988.
22. PALMER, M. R. AND HOFFER, B. J.: Catecholamine modulation of enkephalin-induced electrophysiological responses in cerebral cortex. J. Pharmacol. Exp. Ther. 213: 205-215, 1980.
23. PARFITT, K. D., HOFFER, B. J. AND BICKFORD-WIMER, P. C.: Potentiation of gamma-aminobutyric acid-mediated inhibition by isoproterenol in the cerebellar cortex: Receptor specificity. Neuropharmacology 29: 909-916, 1990.
24. 1 -selective adrenergic agonist. Neurobiol. Aging 11: 591-596, 1990.
25. PITTMAN, R. N., MINNEMAN, K. P. AND MOLINOFF, P. B.: Alterations in beta 1- and beta 2-adrenergic receptor density in the cerebellum of aging rats. J. Neurochem. 35: 273-275, 1980.
26. PURI, S. K. AND VOLICER, L.: Effect of aging on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in the rat corpus striatum. Mech. Ageing Dev. 6: 53-58, 1977.
27. REICHLMEIER, K. D.: Age related changes of cyclic AMP-dependent protein kinase in bovine brain. J. Neurochem. 27: 1249-1251, 1976.
28. SALMOIRAGHI, G. C. AND WEIGHT, F. F.: Micromethods in neuropharmacology: An approach to the study of anesthetics. Anesthesiology 28: 54-64, 1967.
29. SCHMIDT, M. J. AND THORNBERRY, J. F.: Cyclic AMP and cyclic GMP accumulation in vitro in brain regions of young, old and aged rats. Brain Res. 139: 169-177, 1978.
30. SESSLER, F. M., MOURADIAN, R. D., CHENG, J. T., YEH, H. H., LIU, W. AND WATERHOUSE, B. D.: Noradrenergic potentiation of cerebellar Purkinje cell responses to GABA: Evidence for mediation through the β-adrenoceptor-coupled cyclic AMP system. Brain Res. 499: 27-38, 1989.
31. STANCHEVA, S. L. AND ALOVA, L. G.: Age-related changes of cyclic AMP phosphodiesterase activity in rat brain regions and a new phosphodiesterase inhibitor-nootropic agent adafenoxate. Gen. Pharmacol. 22: 955-958, 1991.
32. SUGAWA, M. AND MAY, T.: Age-related alteration in signal transduction: Involvement of the cAMP cascade. Brain Res. 618: 57-62, 1993.
33. A/benzodiazepine receptor α subunit by a receptor-associated protein kinase. J. Neurochem. 51: 1274-1284, 1988.
34. WHITE, M., RODEN, R., MINOBE, W., KHAN, M. F., LARRABEE, P., WOLLMERING, M., PORT, J. D., ANDERSON, F., CAMPBELL, D., FELDMAN, A. M. AND BRISTOW, M. R.: Age-related changes in β-adrenergic neuroeffector systems in the human heart. Circulation 90: 1225-1238, 1994.
35. YEH, H. H. AND WOODWARD, D. J.: Beta-1 adrenergic receptors mediate noradrenergic facilitation of Purkinje cell responses to gamma-aminobutyric acid in cerebellum of rat. Neuropharmacology 22: 629-639, 1983.
36. ZIMMERMAN, I. AND BERG, A.: Levels of adenosine 3′,5′ cyclic monophosphate in the cerebral cortex of aging rats. Mech. Ageing Dev. 3: 33-36, 1974.
37. ZIMMERMAN, I. D. AND BERG, A. P.: Phosphodiesterase and adenyl-cyclase activities in the cerebral cortex of the aging rat. Mech. Ageing Dev. 4: 89-96, 1975.