Aging, metabolism, and Alzheimer disease: Review and hypotheses

Experimental Neurology

Volumn 143, Issue 1, 1997, Pages 82-102

  Finch, Caleb E ^a   Cohen, David M ^b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GLUTAMATE AMMONIA LIGASE; GLYCERALDEHYDE 3 PHOSPHATE;

AGING; ALZHEIMER DISEASE; BRAIN METABOLISM; DIABETES MELLITUS; GLYCATION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; RODENT; SENILE PLAQUE;

EID: 0031033373     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.6339     Document Type: Article

References (220)

1. 1. ABBOTT, R. D., R. P. DONAHUE, S. W. MACMAHON, D. M. REED, AND K. YANO. 1987. Diabetes and the risk of stroke - The Honolulu Heart Program. J. Am. Med. Assoc. 257: 949-952.
2. 2. BELL, D. S. H. 1994. Stroke in the diabetic patient. Diabetes Care 17: 213-219.
3. 3. BERGMAN, R. N. 1989. Toward physiological understanding of glucose tolerance: Minimal model approach. Diabetes 38: 1512-1527.
4. 4. BERGMAN, R. N. 1990. Quantitative approaches to pathogenesis of age-related metabolic conditions. In Biomedical Advances in Aging (A. L. Goldstein, Ed.), Plenum, New York.
5. 5. BRADLEY, S. F., A. VIBHAGOOL, S. L. KUNKEL, AND C. A. KAUFFMAN. 1989. Monokine secretion in aging and protein malnutrition. J. Leukocyte Biol. 45: 510-514.
6. 6. BREWSTER, W. J., P. FERNYHOUGH, L. T. DIEMEL, L. MOHIUDDIN, AND D. R. TOMLINSON. 1994. Diabetic neuropathy, nerve growth factor and other neurotropic factors. Trends Neurosci. 17: 321-324.
7. 7. BROE, G. A., A. S. HENDERSON, H. CREASEY, E. MCCUSKER, A. E. KORTEN, A. F. JORM, W. LONGLEY, AND J. C. ANTHONY. 1990. A case-control study of Alzheimer's disease in Australia. Neurology 40: 1698-1707.
8. 8. BRONSON, R. T. 1990. Rate of occurrence of lesions in 20 inbred and hybrid genotypes of rats and mice sacrificed at 6 month intervals during the first years of life. In Genetic Effects on Aging II (D. E. Harrison, Ed.), Telford Press, Caldwell, NJ.
9. 9. BRUN, A., X. LIU, AND C. ERIKSON. 1995. Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer's disease and in frontal lobe degeneration. Neurodegeneration 4: 171-177.
10. 10. BUCALA, R., A. CERAMI, AND H. VLASSARA. 1995. Advanced glycosylation end products in diabetic complications. Diabetes Rev. 3: 258-268.
11. 11. BUCHT, G., R. ADOLFSSON, F. LITHNER, AND B. WINBLAD. 1983. Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type. Acta Med. Scand. 213: 387-392.
12. 12. BUKATO, G., Z. KOCHAN, AND J. SWIERCZYNSKI. 1995. Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain. Int. J. Biochem. Cell Biol. 27: 1003-1008.
13. 13. BUTTERWORTH, R. F. 1993. Portal-systemic encephalopathy: A disorder of neuron-astrocytic metabolic trafficking. Dev. Neurosci. 15: 313-319.
14. 14. CARNEY, J. M., P. E. STARKE-REED, C. N. OLIVER, R. W. LANDUM, M. S. CHENG, J. F. WU, AND R. A. FLOYD. 1991. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc. Natl. Acad. Sci. USA 88: 3633-3636.
15. 15. CHEN, M., R. N. BERGMAN, G. PACINI, G., AND D. PORTE, JR. 1985. Pathogenesis of age-related glucose intolerance in man: Insulin resistance and decreased β-cell function. J. Clin. Endocrinol. Metab. 60: 13-20.
16. 16. CHEN, M., J. B. HALTER, AND D. PORTE, JR. 1987. The role of dietary carbohydrate in the decreased glucose tolerance of the elderly. J. Am. Geriatr. Soc. 35: 417-424.
17. 17. CHUI, H. C., J. I. VICTOROFF, D. MARGOLIN, W. JAGUST, R. SHANKLE, AND R. KATZMAN. 1992. Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology 42: 473-478.
18. 17a. COHEN, D. M. Inhibition of glutamine synthetase induces critical energy threshold for neuronal survival. In Cerebrovascular Pathology in Alzheimers Disease. Annals N.Y. Acamdemy of Science, in press.
19. 18. COOPER, A. J. L., AND F. PLUM. 1987. Biochemistry and physiology of brain ammonia. Physiol. Rev. 67: 440-519.
20. 19. COOPER, A. J. L., S. N. MORA, N. F. CRUZ, AND A. S. GELBARD. 1985. Cerebral ammonia metabolism in hyperammonemic rats. J. Neurochem. 44: 1716-1723.
21. 20. CORDER, E. H., A. M. SAUNDERS, W. J. STRITTMATTER, D. E. SCHMECHEL, P. C. GASKELL, G. W. SMALL, A. D. ROSES, J. L. HAINES, AND M. A. PERICAK-VANCE. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-923.
22. 21. CRAFT, S., J. NEWCOMER, S. KANNE, S. DAGOGO-JACK, P. CRYER, Y. SHELINE, J. LUBY, A. DAGOGO-JACK, AND A. ALDERSON. 1996. Memory improvement following induced hyperinsulinemia in Alzheimer's disease. Neurobiol. Aging 17: 123-130.
23. 22. CUMMINGS, B. J., E. HEAD, A. J. AFAGH, N. W. MILGRAM, AND C. W. COTMAN. β-Amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol. Learn. Mem. 65, in press.
24. 23. CURB, J. D., B. L. RODRIQUEZ, H. PETROVICH, K. H. MASAKI, C. M. BURCHFIEL, W. ROSS, R. CHEN, T. HARRIS, AND L. R. WHITE. 1996. The relationship of diabetes and glucose tolerance to Alzheimer's disease and vascular dementia. Neurobiol. Aging 17(4S): S122. [Abstract 488].
25. 24. DAVIDSON, M. B. 1979. The effect of aging on carbohydrate metabolism: A review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 28: 688-705.
26. 25. DAVIGNON, J., R. GREGG, AND C. F. SING. 1988. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8: 1-21.
27. 26. DAWSON, T. M., AND S. H. SNYDER. 1994. Gases as biological messengers: Nitric oxide and carbon monoxide in the brain. J. Neurosci. 14: 5147-5159.
28. 27. DAY, J. R., N. J. LAPING, M. LAMPERT-ETCHELLS, S. A. BROWN, J. P. O'CALLAGHAN, T. H. MCNEILL, AND C. E. FINCH. 1993. Gonadal steroids regulate the expression of GFAP in the adult male rat hippocampus. Neuroscience 55: 435-443.
29. 28. DEFRONZO, R. A. 1979. Glucose intolerance in aging. Evidence for tissue insensitivity to glucose. Diabetes 28: 1095-1101.
30. 29. Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329: 977-986.
31. 30. DUARA, R. 1994. Neuroimaging with CT and MRI in Alzheimer disease. In Alzheimer Disease (R. D. Terry, R. Katzman, and K. L. Bick, Eds.), p. 175. Raven Press, New York.
32. 31. DULIC, V., AND A. GAFNI. 1987. Mechanism of aging of rat muscle glyceraldehyde-3-phosphate dehydrogenase studied by selective enzyme-oxidation. Mech. Age. Dev. 40: 289-306.
33. 32. DYCK, P. J., K. M. KRATZ, W. J. LITCHY, R. KLEIN, J. M. PACH, D. M. WILTON, P. C. O'BRIEN, AND L. J. MELTON. 1993. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population based cohort. Neurology 43: 817-824.
34. 33. EICHNER, J. E., R. E. FERRELL, M. I. KAMBOH, L. H. KULLER, D. J. BECKNER, AND T. J. ORCHARD. 1992. The impact of the apolipoprotein E polymorphism on the lipoprotein profile in insulin-dependent diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study IX. Metabolism 41: 347-351.
35. 34. EL KHOURY, J., S. E. HICKMAN, C. A. THOMAS, L. CAO, S. C. SILVERSTEIN, AND J. D. LOIKE. 1996. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature 382: 716-719.
36. 35. EVERITT, A. V., N. J. SEEDSMAN, AND F. JONES. 1980. The effects of hypophysectomy and continuous food restriction, begun at ages of 70 and 400 days on collagen aging, proteinuria, incidence of pathology, and longevity in the male rat. Mech. Age. Dev. 12: 161-172.
37. 36. FAFF-MICHALAK, L., AND J. ALBRECHT. 1991. Aspartate amino-transferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: Effects of in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy. Metab. Brain Dis. 6: 187-197.
38. 37. FERINI-STRAMBI, L., S. SMIRNE, P. GARANCINI, P. PINTO, AND M. FRANCESCHI. 1990. Clinical and epidemiological aspects of Alzheimer's disease with presenile onset: A case control study. Neuroepidemiology 9: 39-49.
39. 38. FINCH, C. E., AND J. MARCHALONIS. 1996. An evolutionary perspective on amyloid and inflammatory features of Alzheimer disease. Neurobiol. Aging 17: 809-815.
40. 39. FINK, R. I., O. G. KOLTERMAN, J. GRIFFIN, AND J. M. OLEFSKY. 1983. Mechanisms of insulin resistance in aging. J. Clin. Invest. 71: 1523-1535.
41. 40. FINK, R. I., P. WALLACE, AND J. M. OLEFSKY. 1986. Effects of aging on glucose-mediated glucose disposal and glucose transport. J. Clin. Invest. 77: 2034-2041.
42. 41. FISHMAN, R. A. 1992. Cerebrospinal Fluid in Diseases of the Nervous System, 2nd ed., pp. 217-220. W. B. Saunders Co. Harcourt, Brace, Jovanovich, Inc., Philadelphia, PA.
43. 42. FRENKEL, R. 1972. Isolation and some properties of a cytosol and a mitochondrial malic enzyme from bovine brain. Arch. Biochem. Biophys. 152: 136-143.
44. 43. GABUZDA, D., J. BUSCIGLIO, L. B. CHEN, P. MATSUDAIRA, AND B. A. YANKER. 1994. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 269: 13623-13628.
45. 44. GAFNI, A., AND N. NOY. 1984. Age-related effects in enzyme catalysis. Mol. Cell. Biochem. 59: 113-129.
46. 45. GIARDINO, I., D. EDELSTEIN, AND M. BROWNLEE. 1994. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. J. Clin. Invest. 94: 110-117.
47. 46. GIRARD, G., J. F. GIGUERE, AND R. F. BUTTERWORTH. 1993. Region-selective reductions in activities of glutamine synthetase in rat brain following portocaval anastomosis. Metab. Brain Dis. 8: 207-215.
48. 47. GOODISON, K. L., I. M. PARHAD, C. L. WHITE, III, A. A. F. SIMA, AND A. W. CLARK. 1993. Neuronal and glial gene expression in neoxortex of Down's syndrome and Alzheimer's disease. J. Neuropathol. Exp. Neurol. 52: 192-198.
49. 48. GORDON, M. N., L. A. HOLCOMB, W. A. SCHREIER, AND D. G. MORGAN. 1994. MHC class II antigen expression by microglial after deafferentation in aged rats. Soc. Neurosci. Abstr. 20: 1033.
50. 49. GOTTFRIES, C. G., AND B. E. ROOS. 1976. Monoamine metabolites in cerebrospinal fluid (CSF) in patients with organic presenile and senile dementias. Akt. Geront. 6: 37-42.
51. 50. GRIFFIN, W. S. T., L. C. STANLEY, C. LING, L. WHITE, V. MACLEOD, L. J. PERROT, C. L. WHITE, III, AND C. ARAOZ. 1989. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA 86: 7611-7615.
52. 51. GRILL, V., O. BJORKMAN, M. GUTNIAK, AND M. LINDQVIST. 1992. Brain uptake and release of amino acids in nondiabetic and insulin-dependent diabetic subjects: Important role of glutamine release for nitrogen balance. Metabolism 41: 28-32.
53. 13C NMR spectroscopy. Proc. Natl. Acad. Sci. USA 89: 1109-1112, 1992; erratum, ibid., 89: 12208.
54. 53. GUMBINER, B., K. S. POLONSKY, W. F. BELTZ, P. WALLACE, G. BRECHTEL, AND R. I. FINK. 1989. Effects of aging on insulin secretion. Diabetes 38: 1549-1556.
55. 54. GUNNERSEN, D., AND B. HALEY. 1992. Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: A potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. USA 89: 11949-11953.
56. 55. HALL, J. L., L. A. GONDER-FREDERICK, W. W. CHEWNING, J. SILVEIRA, AND P. E. GOLD. 1989. Glucose enhancement of performance on memory tests in young and aged humans. Neuropsychologia 9: 1129-1138.
57. 56. HALLIWELL, B. 1992. Reactive oxygen species and the central nervous system. J. Neurochem. 59: 1609-1623.
58. 57. HALTER, J. B. 1996. Alzheimer's disease and non-insulin-dependent diabetes mellitus: Common features do not make common bedfellows. J. Am. Geriatr. Soc. 44: 992-993. [Editorial].
59. 58. HARRIS, M. I., W. C. HADDEN, W. C. KNOWLER, AND P. H. BENNETT. 1987. Prevalence of Diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes 36: 523-534.
60. 59. HARRIS, M. I. 1993. Undiagnosed NIDDM: Clinical and public health issues. Diabetes Care 16: 642-652.
61. 60. HARRIS, M. I. 1995. Epidemiologic studies on the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). Clin. Invest. Med. 18: 231-239.
62. 61. HENSLEY, K., J. M. CARNEY, M. P. MATTSON, M. AKSENOVA, M. HARRIS, J. F. WU, R. A. FLOYD, AND D. A. BUTTERFIELD. 1994. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease. Proc. Natl. Acad. Sci. 91: 3270-3274.
63. 62. HERTZ, L. 1993. Metabolic interactions between neurons and astrocytes. In Biology and Pathology of Astrocyte-Neuron Interactions (S. Fedoroff, B. H. J. Juurlink, and R. Doucette, Eds.), Plenum, New York.
64. 63. HEYDARI, A. R., B. WU, R. Y. TAKAHASHI, R. STRONG, AND A. RICHARDSON. 1993. Expression of heat shock protein 70 is altered by age and diet at the level of transcription. Mol. Cell. Biol. 13: 2909-2918.
65. 64. HEYMAN, A., W. E. WILKINSON, B. J. HURWITZ, D. SCHMECHEL, A. H. SIGMON, T. WEINBERG, M. J. HELMS, AND M. SWIFT. 1983. Alzheimer's disease: Genetic aspects and associated clinical disorders. Ann. Neurol. 14: 507-515.
66. 65. HEYMAN, A., W. E. WILKINSON, J. A. STAFFORD, M. J. HELMS, A. H. SIGMON, AND T. WEINBERG. 1984. Alzheimer's disease: A study of epidemiological aspects. Ann. Neurol. 15: 335-341.
67. 66. HOPKIN, K. 1995. Aging in focus: Caloric restriction may put the brakes on aging. J. NIH Res. 7: 47-50.
68. 67. HORI, N., I. HIROTSU, P. J. DAVIS, AND D. O. CARPENTER. 1992. Long-term potentiation is lost in aged rats but preserved by calorie restriction. NeuroReport 3: 1085-1088.
69. 68. HOTHERSALL, J. S., A. L. GREENBAUM, AND P. MCLEAN. 1982. The functional significance of the pentose phosphate pathway in synaptosomes: Protection against peroxidative damage by catecholamines and oxidants. J. Neurochem. 39: 1325-1332.
70. 69. HOYER, S. 1993. Intermediary metabolism disturbance in AD/SDAT and its relation to molecular events. Prog. NeuroPsychopharmacol. Biol. Psychiatr. 17: 199-228.
71. 70. HOYER, S. 1994. Possible role of ammonia in the brain in dementia of Alzheimer type. Adv. Exp. Med. Biol. 368: 197-205.
72. 71. HOYER, S., AND R. NITSCH. 1989. Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type. J. Neural Transm. 75: 227-232.
73. 72. HU, J. R., AND E. E. EL-FAKAHANY. 1993. Beta amyloid 25-35 activates nitric oxide synthase in a neuronal clone. NeuroReport 4: 760-762.
74. 73. HYMAN, B. T., K. MARZLOFF, AND P. V. ARRIAGADA. 1993. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J. Neuropathol. Exp. Neurol. 52: 594-600.
75. 74. ISSA, A. M., W. ROWE, S. GAUTHIER, AND M. J. MEANEY. 1990. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J. Neurosci. 10: 3247-3254.
76. 75. JESSY, J., M. R. DEJOSEPH, AND R. A. HAWKINS. 1991. Hyperammonemia depresses glucose consumption throughout the brain. Biochem. J. 277: 693-696.
77. 76. KAHN, S. E., V. G. LARSON, J. C. BEARD, K. C. CAIN, G. W. FELLINGHAM, R. S. SCHWARTZ, R. C. VEITH, J. R. STRATTON, M. D. CERQUEIRA, AND I. B. ABRASS. 1990. Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. Am. J. Physiol. 258: E937-E943.
78. 77. KAHN, S. E., V. G. LARSON, R. S. SCHWARTZ, J. C. BEARD, K. C. CAIN, G. W. FELLINGHAM, J. R. STRATTON, M. D. CERQUEIRA, AND I. B. ABRASS. 1992. Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging. J. Clin. Endocrinol. Metab. 74: 1336-1342.
79. 78. KATZMAN, R. 1983. Vascular disease and dementia. In H. Houston Merritt Memorial Volume (M. D. Yahr, Ed.), pp. 153-176. Raven Press, New York.
80. 79. KATZMAN, R., AND C. KAWAS. 1994. The epidemiology of dementia and Alzheimer disease. In Alzheimer Disease (R. D. Terry, R. Katzman and K. L. Bick, Eds.), p. 105. Raven Press, New York.
81. 80. KEMPER, T. 1984. Neuroanatomical and neuropathological changes in normal aging and in dementia. In Clinical Neurology of Aging (M. L. Albert, Ed.), pp. 9-52. Oxford Univ. Press, New York.
82. 81. KIMURA, T., J. TAKAMATSU, N. ARAKI, M. GOTO, A. KONDO, T. MIYAKAWA, AND S. HORIUCHI. 1995. Are advanced glycation end-products associated with amyloidosis in Alzheimer's disease. NeuroReport 6: 866-868.
83. 82. KIRSTEIN, M., J. BRETT, S. RADOFF, S. OGAWA, D. STERN, AND H. VLASSARA. 1990. Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: Role in vascular disease of diabetes and aging. Proc. Natl. Acad. Sci. USA 87: 9010-9014.
84. 83. KOENIG, R. J., C. M. PETERSON, R. L. JONES, C. SAUDEK, M. LEHRMAN, AND A. CERAMI. 1976. Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus. N. Engl. J. Med. 295: 17-120.
85. 84. KOHAMA, S. G., J. R. GOSS, C. E. FINCH, AND T. H. MCNEILL. 1995. Increases of glial fibrillary acidic protein in the aging female mouse brain. Neurobiol. Aging 16: 59-67.
86. 85. KOKMEN, E., C. M. BEARD, V. CHANDRA, K. P. OFFORD, B. S. SCHOENBERG, AND D. J. BALLARD. 1991. Clinical risk factors for Alzheimer's disease: A population-based case-control study. Neurology 41: 1393-1397.
87. 86. KRISTAL, B. S., AND B. P. YU. 1992. An emerging hypothesis: Synergistic induction of aging by free radicals and Maillard reactions. J. Gerontol. Biol. Sci. 47: B107-B114.
88. 87. KURZ, G. M., H. WIESINGER, AND B. HAMPRECHT. 1993. Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures. J. Neurochem. 60: 1467-1474.
89. 88. KUUSISTO, J., L. MYKKANEN, K. PYORALA, AND M. LAAKSO. 1994. Non-insulin-dependent diabetes and its metabolic control are important predictors of stroke in elderly patients. Stroke 25: 1157-1164.
90. 89. LAI, J. C. K., AND A. J. L. COOPER. 1986. Brain α-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution, and effects of inhibitors. J. Neurochem. 47: 1376-1386.
91. 90. LANDFIELD, P. W., G. ROSE, L. SANDLES, T. C. WOHLSTADTER, AND G. LYNCH. 1977. Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of aged, memory-deficient rats. J. Gerontol. 32: 3-12.
92. 91. LANDFIELD, P. W., J. L. WAYMIRE, AND G. LYNCH. 1978. Hippocampal aging and adrenocorticoids: Quantitative correlations. Science 202: 1098-1102.
93. 92. LANDFIELD, P. W., R. W. BASKIN, AND T. A. PITLER. 1981. Brain-aging correlates: Retardation by hormonal-pharmacological treatments. Science 214: 581-584.
94. 93. LANDFIELD, P. W. 1987. Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally active peptides. Prog. Brain Res. 72: 279-300.
95. 94. LANDFIELD, P. W. 1994. The role of glucocorticoids in brain aging and Alzheimer's disease: An integrative physiological hypothesis (Nathan Shock Memorial Lecture 1990). Exp. Gerontol. 29: 3-11.
96. 95. LANDIN, K., K. BLENNOW, A. WALLIN, AND C.-G. GOTTFRIES. 1993. Low blood pressure and blood glucose levels in Alzheimer's disease: Evidence for a hypometabolic disorder? J. Intern. Med. 233: 357-363.
97. 96. LAPING, N. J., B. TETER, N. R. NICHOLS, J. ROZOVSKY, AND C. E. FINCH. 1994. Glial fibrillary acidic protein: Regulation by hormones, cytokines, and growth factors. Brain Pathol. 4: 259-274.
98. 97. LEHTO, S., T. RONNEMAA, K. PYORALA, AND M. LAAKSO. 1996. Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes. Stroke 27: 63-68.
99. 98. LEIBSON, C. L., W A. ROCCA, V. A. HANSON, R. CHA, E. KOKMEN, P. C. O'BRIEN, AND P. J. PALUMBO. The risk of dementia among persons with diabetes mellitus: A population based cohort study. Am. J. Epidemiol., in press.
100. 99. LEVIN, P., J. K. JANDA, J. A. JOSEPH, D. K. INGRAM, AND G. S. ROTH. 1981. Dietary restriction retards the age-associated loss of rat striatal dopaminergic receptors. Science 214: 561-562.
101. 100. LEVINE, R. L., AND E. STADTMAN. 1996. Protein modifications with aging, in Handbook of the Biology of Aging, (E. L. Schneider and J. W. Rowe, Eds.), 4th ed., pp. 184-197. Academic Press, San Diego.
102. 101. LEVY, R., A. ISAACS, AND G. HAWKS. 1970. Neurophysiological correlates of senile dementia: I. motor and sensory nerve conduction velocity. Psychol. Med. 1: 40-47.
103. 102. LI, J. J., D. VOISIN, A-L. QUIQUEREZ, AND C. BOURAS. 1994. Differential expression of advanced glycosylation end-products in neurons of different species. Brain Res. 641: 285-288.
104. 103. LI, J. L., M. SURINI, S. CATSICAS, E. KAWASHIMA, AND C. BOURAS. 1995. Age-dependent accumulation of advanced glycosylation end products in human neurons. Neurobiol. Aging. 16: 69-76.
105. 104. LOWENSON, J. D., A. E. ROHER, AND S. CLARKE. 1994. Protein aging - Extracellular amyloid formation and intracellular repair. Trends Cardiovasc. Med. 4: 3-8.
106. 105. LUPIEN, S., A. R. LECOURS, I. LUSSIER, G. SCHWARTZ, N. P. V. NAIR, AND M. J. MEANEY. 1994. Basal cortisol levels of cognitive deficits in human aging. J. Neurosci. 14: 2893-2903.
107. 106. LUPIEN, S., A. R. LECOURS, G. SCHWARTZ, S. SHARMA, R. L. HAUGER, M. J. MEANEY, N. P. V. NAIR. 1996. Longitudinal study of basal cortisol levels in health elderly subjects: Evidence for subgroups. Neurobiol. Aging 17: 95-105.
108. 107. MAJOR, D. E., J. P. KESSLAK, C. W. COTMAN, C. E. FINCH, J. R. DAY. Life-long dietary restriction attentuates age-related increases in glial fibrillary acidic protein (GFAP) mRNA in the rat hippocampus. Brain Res., in press.
109. 108. MANN, D. M. A., B. MARCYNIUK, P. O. YATES, D. NEARY, AND J. S. SNOWDEN. 1988. The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. Neuropathol. Appl. Neurol. 14: 177-195.
110. 109. MANNING, C. A., J. L. HALL, AND P. E. GOLD. 1990. Glucose effects on memory and other neuropsychological tests in elderly humans. Psych. Sci. 1: 307-311.
111. 110. MANSON, J. E., G. A. COLDITZ, M. J. STAMPFER, W. C. WILLETT, A. S. KROLEWSKI, B. ROSNER, R. A. ARKY, F. E. SPEIZER, AND C. H. HENNEKENS. 1991. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch. Int. Med. 151: 1141-1147.
112. 111. MARTINS, R. N., C. G. HARPER, G. B. STOKES, AND C. L. MASTERS. 1986. Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress. J. Neurochem. 46: 1042-1045.
113. 112. MASORO, E. J., R. J. M. MCCARTER, M. S. KATZ, AND C. A. MCMAHAN. 1992. Dietary restriction alters characteristics of glucose fuel use. J. Gerontol. Biol. Sci. 47: B202-B208.
114. 113. MASTERS, P. M. 1983. Stereochemically altered noncollagenous protein from human dentin. Calc. Tiss. Int. 35: 43-47.
115. 114. MASTROGIACOMO, F., C. BERGERON, AND S. J. KISH. 1993. Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J. Neurochem. 61: 2007-2014.
116. 115. MATTSON, M. P., J. W. CARNEY, AND D. A. BUTTERFIELD. 1995. A tombstone in Alzheimer's? Nature 373: 481. [Letter]
117. 116. MCDONALD, L. J., AND J. MOSS. 1993. Stimulation by nitric oxide of an NAD linkage to glyceraldehyde-3-phosphate dehydrogenase. Proc. Natl. Acad. Sci. USA 90: 6238-6241.
118. 117. MCGEER, P. L., AND E. G. MCGEER. 1992. Complement proteins and complement inhibitors in Alzheimer's disease. Res. Immunol. 143: 621-623.
119. 118. MCKHANN, G., D. DRACHMAN, M. FOLSTEIN, R. KATZMAN, D. PRICE, AND E. M. STADLAN. 1984. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
120. 119. MEANEY, M. J., D. H. AITKEN, S. BHATNAGAR, C. VAN BERKEL, AND R. M. SAPOLSKY. 1988. Postnatal handling attenuates neuroendocrine, anatomical, and cognitive impairments related to the aged hippocampus. Science 238: 766-768.
121. 120. MENEILLY, G. S., AND A. HILL. 1993. Alterations in glucose metabolism in patients with Alzheimer's disease. J. Am. Geriatric Soc. 41: 710-714.
122. 121. MIRRA, S. S., A. HEYMAN, D. MCKEEL, S. M. SUMI, B. J. CRAIN, L. M. BROWNLEE, F. S. VOGEL, J. P. HUGHES, G. VAN BELLE, L. BERG, AND Participating CERAD Neuropathologists. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41: 479-486.
123. 122. MOATS, R. A., T. ERNS, T. K. SHONK, AND B. D. ROSS. 1994. Abnormal cerebral metabolite concentrations in patients with probable Alzheimer disease. Magn. Reson. Med. 32: 110-115.
124. 123. MOHR, S., J. S. STAMLER, AND B. BRUNE. 1994. Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite, and related nitrosating agents. FEBS Lett. 348: 223-227.
125. 124. MORGAN, T. E., N. J. LAPING, I. ROZOVSKY, T. ODA, H. HOGAN, C. E. FINCH, G. M. PASINETTI. 1995. Clusterin expression in astrocytes is influenced by TGF-β1 and heterotypic cell interactions. J. Neuroimmunol. 58: 101-110.
126. 125. MORRIS, J. C., M. STORANDT, D. W. MCKEEL, E. H. RUBIN, J. L. PRICE, E. A. GRANT, AND L. BERG. 1996. Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease. Neurology 46: 707-719.
127. 126. MORRIS, J. C., A. HEYMAN, R. C. MOHS, J. P. HUGHES, G. VAN BELLE, G. FILLENBAUM, E. D. MELLITS, C. CLARK, and the CERAD Investigators. 1989. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39: 1159-1165.
128. 127. DELETED IN PROOF.
129. 128. MORTEL, K. F., S. WOOD, M. A. PAVOL, J. S. MEYER, AND J. L. REXER. 1993. Analysis of familial and individual risk factors among patients with ischemic vascular dementia and Alzheimer's disease. Angiology 44: 599-605.
130. 129. MUNCK, A., P. GUYRE, AND N. HOLBROOK. 1984. Physiological functions of glucocorticoids during stress and their relation to pharmacological actions. Endo. Rev. 5: 25-49.
131. 130. MURPHY JR., G. M., W. G. ELLIS, Y-L. LEE, K. E. STULTZ, R. SHRIVASTAVA, J. R. TINKLENBERG, AND L. F. ENG. 1992. In Progress in Brain Research. (A. C. H. Yu, L. Hertz, M. D. Norenberg, E. Sykova and S. G. Waxman, Eds.), p. 475. Elsevier, New York.
132. 131. MUTISYA, E. M., A. C. BOWLING, AND M. F. BEAL. 1994. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63: 2179-2184.
133. 132. MYHRER, T. 1993. Animal models of Alzheimer's disease: Glutamatergic denervation as an alternative approach to cholinergic denervation. Neurosci. and Biobehavioral Reviews 17: 195-202.
134. 133. NAGARAJ, R. H., AND V. M. MONNIER. 1992. Isolation and characterization of a blue fluorophore from human eye lens crystallins: In vitro formation from Maillard reaction with ascorbate and ribose. Biochim. Biophys. Acta 1116: 34-42.
135. 134. NAGARAJ, R. H., T. S. KERN, D. R. SELL, J. FOGARTY, R. L. ENGERMAN, AND V. M. MONNIER. 1996. Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Diabetes 45: 587-594.
136. 135. NASLUND, J., J. THYBERG, L. O. TJERNBERG, C. WERNSTEDT, A. R. KARLSTROM, N. BOGDANOVIC, S. E. GANDY, L. LANNFELT, L. TERENIUS, AND C. NORDSTEDT. 1995. Characterization of stable complexes involving apolipoprotein E and the amyloid β peptide in Alzheimer's disease brain. Neuron 15: 219-228.
137. 136. NEEPER, M., A. M. SCHMIDT, J. BRETT, S. D. YAN, F. WANG, Y-C. E. PAN, K. ELLISTON, D. STERN, AND A. SHAW. 1992. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 267: 14998-15004.
138. 137. NICHOLS, N. R., C. E. FINCH, AND J. F. NELSON. 1995. Food restriction delays the age-related increases of GFAP mRNA in rat hypothalamus. Neurobiol. Aging 16: 105-110.
139. 138. NIELSON, K. A., J. H. NOLAN, N. C. BERCHTOLD, C. A. SANDMAN, R. A. MULNARD, AND C. W. COTMAN. 1996. Apolipoprotein-E genotyping of diabetic dementia patients: Is diabetes rare in Alzheimer disease? J. Am. Geriatr. Soc. 44: 1-8.
140. 139. NORENBERG, M. D., AND A. MARTINEZ-HERNANDEZ. 1979. Fine structural localization of glutamine synthetase in astrocytes in rat brain. Brain Res. 161: 303-310.
141. 140. NORENBERG, M. D. 1987. The role of astrocytes in hepatic encephalopathy. Neurochem. Pathol. 6: 13-33.
142. 141. NORENBERG, M. D., AND Y. ITZHAK. 1995. Acute liver failure and hyperammonemia increase nitric oxide synthase in mouse brain. Soc. Neurosci. Abstracts 21: 869. [No. 345.9]
143. 142. NOY, N., H. SCHWARTZ, AND A. GAFNI. 1985. Age-related changes in the redox status of rat muscle cells and their role in enzyme-aging. Mech. Age. Dev. 29: 63-69.
144. 143. O'BRIEN, M. D. 1988. Vascular dementia is underdiagnosed. Arch. Neurol. 45: 797-798.
145. 144. OLIVER, C. N., P. E. STARKE-REED, E. R. STADTMAN, G. J. LIU, J. M. CARNEY, AND R. A. FLOYD. 1990. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc. Natl. Acad. Sci. USA 87: 5144-5147.
146. 145. O'STEEN, W. K., AND P. W. LANDFIELD. 1991. Dietary restriction does not alter retinal aging in the Fischer 344 rat. Neurobiol. Aging 12: 455-462.
147. 146. O'STEEN, W. K., L. B. CADWALLADER, S. VINSANT, AND P. W. LANDFIELD. 1991. Biomarkers of hippocampal and retinal aging are not altered by dietary restriction. Soc. Neurosci. Abstr. 16: 1161. [No. 480.16]
148. 147. OTT, A., R. P. STOLK, M. M. B. BRETELER, AND A. HOFMAN. 1996. The association between diabetes mellitus and dementia. Neurology Feb. [Abstract P05.084]
149. 148. PALMER, A. M., AND S. GERSHON. 1990. Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? FASEB J. 4: 2745-2752.
150. 149. PELLIGRINO, D. A., J. C. LAMANNA, R. B. DUCKROW, R. M. BRYAN, JR., AND S. I. HARIK. 1992. Hyperglycemia and blood-brain barrier glucose transport. J. Cerebr. Blood Flow Metab. 12: 887-899.
151. 150. PEPPARD, R. F., W. R. W. MARTIN, C. M. CLARK, G. D. CARR, P. L. MCGEER, AND D. B. CALNE. 1990. Cortical glucose metabolism in Parkinson's and Alzheimer's disease. J. Neurosci. Res. 27: 561-568.
152. 151. PERRY, V. H., M. K. MATYSZAK, AND S. FEARN. 1993. Altered antigen expression of microglia in the aged rodent CNS. GLIA 7: 60-67.
153. 152. PITSIKAS, N., AND S. ALGERI. 1992. Deterioration of spatial and nonspatial reference and working memory in aged rats: Protective effect of life-long calorie restriction. Neurobiol. Aging 13: 369-373.
154. 153. POIRIER, J., J. DAVIGNON, D. BOUTHILLIER, S. KOGAN, P. BERTRAND, AND S. GAUTHIER 1993. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342: 697-699.
155. 154. PROCTOR, A. W., A. M. PALMER, P. T. FRANCIS, S. L. LOWE, D. NEARY, E. MURPHY, R. DOSHI, AND D. M. BOWEN. 1988. Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease. J. Neurochem. 50: 790-802.
156. 155. PUGLIESE, G., R. G. TILTON, AND J. R. WILLIAMSON. 1991. Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease. Diabetes Metab. Rev. 7: 35-59.
157. 3H]arginine uptake in brain following portacaval anastomosis. J. Neurochem. 65: 677-681.
158. 157. RAPOPORT, S. I., B. HORWITZ, C. L. GRADY, J. V. HAXBY, C. DECARLI, AND M. B. SCHAPIRO. 1991. Abnormal brain glucose metabolism in Alzheimer's disease, as measured by positron emission tomography. Adv. Exp. Med. Biol. 291: 231-248.
159. 158. REAVEN, G. M., AND E. P. REAVEN. 1985. Age, glucose intolerance, and non-insulin-dependent diabetes mellitus. J. Am. Geriatr. Soc. 33: 286-290.
160. 159. REAVEN, G. M., L. W. THOMPSON, D. NAHUM ET AL. 1990. Relationship between hyperglycemia and cognitive function in older NIDDM patients. Diabetes Care 13: 16-21.
161. 160. REISER, K. M. 1994. Influence of age and long-term dietary restriction on enzymatically mediated crosslinks and nonenzymatic glycation of collagen in mice. J. Gerontol. 49: B71-B79.
162. 161. RODGERS, B., A. LAU, C. NICOL. 1994. Hypophysectomy or adrenalectomy of rats with insulin-dependent diabetes mellitus partially restores responsiveness to GH. Proc. Soc. Exp. Biol. Med. 207: 220-226.
163. 162. ROHER, A. E., J. D. LOWENSON, S. CLARKE, A. S. WOODS, R. J. COTTER, E. GOWING, AND M. J. BALL. 1993. β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer disease. Proc. Nat. Acad. Sci. USA 90: 10836-10840.
164. 163. ROTH, G. S., D. K. INGRAM, AND J. A. JOSEPH. 1984. Delayed loss of striatal dopamine receptors during aging of dietarily restricted rats. Brain Res. 300: 27-32.
165. 164. ROTHMAN, D. L., E. J. NOVOTNY, G. I. SHULMAN, A. M. HOWSEMAN, O. A. C. PETROFF, G. MASON, T. NIXON, C. C. HANSTOCK, J. W. PRICHARD, AND R. G. SHULMAN. 1992. 1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain. Proc. Natl. Acad. Sci. USA 89: 9603-9606.
166. 165. ROWE, J. W., K. L. MINAKER, J. A. PALLOTTA, AND J. S. FLIER. 1983. Characterization of the insulin resistance of aging. J. Clin. Invest. 71: 1581-1587.
167. 166. RYLE, C., AND M. DONAGHY. 1995. Non-enzymatic glycation of peripheral nerve proteins in human diabetics. J. Neurol. Sci. 129: 62-68.
168. 167. SABATINO, F., E. J. MASORO, C. A. MCMAHAN, AND R. W. KUHN. 1991. Assessment of the role of glucocorticoid system in aging processes and in the action of food restriction. J. Gerontol. 46: B171-B179.
169. 168. SALO, M. K., R. RANTANEN, T. HUUPPONEN, T. LEHTIMAKI, H. JOKELA. 1993. Apolipoprotein E phenotypes and plasma lipids in diabetic children and adolescents. Eur. J. Pediat. 152: 564-588.
170. 169. SAPOLSKY, R. M. 1985. A mechanism for glucocorticoid toxicity in the hippocampus: Increased neuronal vulnerability to metabolic insults. J. Neurosci. 5: 1228-1232.
171. 170. SAPOLSKY, R. M., H. UNO, C. S. REBERT, AND C. E. FINCH. 1990. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J. Neurosci. 10: 2897-2902.
172. 171. SAPOLSKY, R. M. 1992. Stress, the Aging Brain, and the Mechanisms of Neuron Death, MIT Press, Cambridge, MA.
173. 172. SASAKI, H., O. MURAMOTO, I. KANAZAWA, H. ARAI, K. KOSAKA, AND R. IIZUKA. 1986. Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type. Ann. Neurol. 19: 263-269.
174. 173. SCHIPPER, H., J. R. BRAWER, J. F. NELSON, L. S. FELICIO, AND C. E. FINCH. 1981. Role of the gonads in the histologic aging of the hypothalamic arcuate nucleus. Biol. Reprod. 25: 413-419.
175. 174. SCHIPPER, H. M. 1996. Astrocytes, brain aging and neurodegeneration. Neurobiol. Aging 17: 467-480.
176. 175. SCHMOLL, D., E. FUHRMANN, R. GEBHARDT, AND B. HAMPRECHT. 1995. Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphenolpyruvate carboxykinase isoenzyme. Eur. J. Biochem. 227: 308-315.
177. 176. SCHUBERT, D. 1994. The Structure and Function of Alzheimer's Amyloid Beta Proteins. R. G. Landes, Austin, TX.
178. 1H MRS at 4 Tesla. Proc. Int. Soc. Magnet. Resonance in Med. 1: 409 [Abstract]
179. 178. SEEMAN, T. E., L. F. BERKMAN, D. BLAZER, AND J. W. ROWE. 1994. Social ties and support and neuroendocrine function: The Macarthur studies of successful aging. Ann Behav. Med. 16: 95-106.
180. 179. SEILER, N. 1993. Is ammonia a pathogenetic factor in Alzheimer's disease? Neurochem. Res. 18: 235-245.
181. 180. SELKOE, D. J. 1994. Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17: 489-517.
182. 181. SELKOE, D., AND K. KOSIK. 1984. Neurochemical changes with aging. In Clinical Neurology of Aging (M. L. Albert, Ed.), pp. 53-75. Oxford Univ. Press, New York.
183. 182. SELL, D. R., AND V. M. MONNIER. 1990. Structure elucidation of a senescence cross-link from human extracellular matrix. J. Biol. Chem. 266: 21597-21602.
184. 183. SELL, D. R., M. A. LANE, W. A. JOHNSON, E. J. MASORO, O. B. MOCK, K. REISER, J. F. FOGARTY, R. G. CUTLER, D. K. INGRAM, G. S. ROTH, V. M. MONNIER. 1996. Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. Proc. Natl. Acad. Sci. USA 93: 485-490.
185. 184. SERVO, C., AND E. PITKANEN. 1975. Variation in polyol levels in cerebrospinal fluid and serum in diabetic patients. Diabetologia 11: 575-580.
186. 185. SHANK, R. P., G. S. BENNETT, S. O. FREYTAG, AND G. CAMPBELL. 1985. Pyruvate carboxylase: an astrocytic-specific enzyme implicated in the replenishment of amino acid transmitter pools. Brain Res. 329: 364-367.
187. 186. SHIMOKATA, H., D. C. MULLER, J. L. FLEG, J. SORKIN, A. W. ZIEMBA, AND R. ANDRES. 1991. Age as Independent Determinant of Glucose Tolerance. Diabetes 40: 44-51.
188. 187. SHIMOKAWA, I., Y. HIGAMI, G. B. HUBBARD, C. A. MCMAHAN, E. J. MASORO, AND B. P. YU. 1993. Diet and the suitability of the male Fischer 344 rat as a model for aging research. J. Gerontol. 48: B27-B32.
189. 188. SISODIA, S. S., AND D. L. PRICE. 1995. Role of the β-amyloid protein in Alzheimer's disease. FASEB J. 9: 366-370.
190. 189. SMITH, C. D., J. M. CARNEY, P. E. STARKE-REED, C. N. OLIVER, E. R. STADTMAN, R. A. FLOYD, AND W. R. MARKESBERY. 1991. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc. Natl. Acad. Sci. USA 88: 10540-10543.
191. 190. SMITH, M. A., S. TANEDA, P. L. RICHEY, S. MIYATA, S.-D. YAN, D. STERN, L. M. SAYRE, V. M. MONNIER, AND G. PERRY. 1994. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc. Natl. Acad. Sci. USA 91: 5710-5714.
192. 191. SMITH, M. A., L. M. SAYRE, AND G. PERRY. 1996. Diabetes mellitus and Alzheimer's disease: Glycation as a biochemical link. Diabetologia 39: 247.
193. 13C]-NMR spectroscopy: Incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle. J. Neurochem. 61: 1179-1182.
194. 192a. SPARKS, D. L., WOELTZ, V. M., AND MARKESBERY, W. R. 1991. Alterations in brain monoamine oxidase activity in aging, Alzheimer's disease, and Pick's disease. Arch. Neurol. 48: 718-721.
195. 193. STADTMAN, E. R. 1992. Protein oxidation and aging. Science 257: 1220-1224.
196. 194. STONE, W. S., G. L. WENK, D. S. OLTON, AND P. E. GOLD. 1990. Poor blood glucose regulation predicts sleep and memory deficits in normal aged rats. J. Gerontol. 45: B169-B173.
197. 195. STRITTMATTER, W. J., A. M. SAUNDERS, D. SCHMECHEL, M. PERICAK-VANCE, J. ENGHILD, G. S. SALVESEN, AND A. D. ROSES. 1993. Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90: 1977-1981.
198. 196. STRYER, L. 1988. Biochemistry, 3rd ed. W. H. Freeman, New York.
199. 197. TATEMICHI, T. K., N. SACKTOR, AND R. MAYEUX. 1994. Dementia associated with cerebrovascular disease, other degenerative diseases and metabolic disorders. In Alzheimer Disease (R. D. Terry, R. Katzman and K. L. Bick, Eds.), pp. 123 Raven Press, New York.
200. 198. TERRY, R. D., E. MASLIAH, AND L. A. HANSEN. 1994. Structural basis of the cognitive alterations in Alzheimer disease. In Alzheimer Disease (R. D. Terry, R. Katzman and K. L. Bick, Eds.), pp. 179-198. Raven Press, New York.
201. 199. THORPE, J., L. P. WIDMAN, A. WALLIN, J. BEISWANGER, AND H. T. BLUMENTHAL. 1994. Comorbidity of other chronic age-dependent diseases in dementia. Aging Clin. Exp. Res. 6: 159-166.
202. 200. TSACOPOULOS, M., AND P. J. MAGISTRETTI. 1996. Metabolic coupling between glia and neurons. J. Neurosci. 16: 877-885.
203. 201. VEERHUIS, R., I. JANSSEN, C. E. HACK, AND P. EIKELENBOOM. 1995. Early complement components in Alzheimer's disease brains. Acta Neuropathol. 91: 53-60.
204. 202. VIRGIN, C., T. HA, D. PACKAN, C. TOMBAUGH, S. YANG, H. HORNER, AND R. SAPOLSKY. 1991. Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: Implications for glucocorticoid neurotoxicity. J. Neurochem. 57: 1422.
205. 203. VITEK, M. P., K. BJATTACHARYA, M. J. GLENDENING, E. STOPA, H. VLASSARA, R. BUCALA, K. MANOGUE, AND A. CERAMI. 1994. Advanced glycation end products contribute to amyloidosis in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 91: 4766-4770.
206. 204. VLASSARA, H., M. BROWNLEE, AND A. CERAMI. 1984. Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation endproducts. J. Exp. Med. 160: 197-207.
207. 205. VLASSARA, H., M. BROWNLEE, AND A. CERAMI. 1985. Recognition and uptake of human diabetic peripheral nerve myelin by macrophages. Diabetes 34: 553-557.
208. 206. VLASSARA, H., H. FUH, Z. MAKITA, S. KRUNGKRAI, A. CERAMI, AND R. BUCALA. 1992. Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: A model for diabetic and aging complications. Proc. Natl. Acad. Sci. USA 89: 12043-12047.
209. 207. VLASSARA, H., R. BUCALA, AND L. STRIKER 1994. Biology of disease: Pathogenic effects of advanced glycosylation: Biochemical, biologic, and clinical implications for diabetes and aging. Lab. Invest. 70: 138.
210. 2 fixation in mammalian brain in vivo. J. Neurochem. 11: 717-728.
211. 209. WEINDRUCH, R. H., AND R. L. WALFORD. 1988. The Retardation of Aging and Disease by Dietary Restriction. Springfield, IL.
212. 210. WESTERGAARD, N., U. SONNEWALD, A. SCHOUSBOE. 1994a. Release of α-ketoglutarate, malate and succinate from cultured astrocytes: Possible role in amino acid neurotransmitter homeostasis. Neurosci. Letts. 176: 105-109.
213. 211. WESTERGAARD, N., U. SONNEWALD, G. UNSGARD, L. PENG, L. HERTZ, AND A. SCHOUSBOE. 1994b. Uptake, release, and metabolism of citrate in neurons and astrocytes in primary cultures. J. Neurochem. 62: 1727-1733.
214. 212. WILLIAMS, S. K., N. L. HOWARTH, J. J. DEVENNY, AND M. W. BITENSKY. 1982. Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus. Proc. Natl Acad. Sci. USA 79: 6546-6550.
215. 213. WOLF-KLEIN, G. P., F. A. SILVERSONE, M. S. BROD, A. LEVY, C. J. FOLEY, V. TERMOTTO, AND J. BREUER. 1988. Are Alzheimer patients healthier? J. Am. Geriatr. Soc. 36: 219-224.
216. 214. YAN, S.-D., X. CHEN, A.-M. SCHMIDT, J. BRETT, G. GODMAN, Y-S., ZOU, C. W. SCOTT, C. CAPUTO, T. FRAPPIER, M. A. SMITH, G. PERRY, S.-H. YEN, AND D. STERN. 1994. Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress. Proc. Natl. Acad. Sci. 91: 7787-7795.
217. 215. YAN, S. D., S. F. YAN, X. CHEN, J. FU, M. CHEN, P. KUPPUSAMY, M. A. SMITH, G. PERRY, G. C. GODMAN, P. NAWROTH, J. L. ZWEIER, AND D. STERN. 1995. Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide. Nature Med. 1: 693-699.
218. 216. YAN, S. D., X. CHEN, J. FU, M. CHEN, H. ZHU, A. ROHER, T. SLATTERY, L. ZHAO, M. NAGASHIMA, J. MORSER, A. MIGHELI, P. NAWROTH, D. STERN, AND A. M. SCHMIDT. 1996. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382: 685-691.
219. 217. ZHANG, J., AND S. H. SNYDER. 1992. Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Proc. Natl. Acad. Sci. USA 89: 9382-9385.
220. 218. ZYZAK, D. V., J. M. RICHARDSON, S. R. THORPE, AND J. W. BAYNES. 1995. Formation of reactive intermediates from Amadori compounds under physiological conditions. Arch. Biochem. Biophys. 316: 547-554.