Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells

Biochemical Pharmacology

Volumn 58, Issue 4, 1999, Pages 655-664

  Vahrmeijer, Alexander L ^a,b   Van Dierendonck, Jan Hein ^a   Schutrups, Jan ^a,b   Van De Velde, Cornelis J H ^a   Mulder, Gerard J ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Apoptosis; Buthionine sulfoximine; Cell cycle kinetics; Glutathione; HT 29 colorectal cancer cell line; Melphalan

Indexed keywords

ACETYLCYSTEINE; ANNEXIN; ANTIOXIDANT; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; DEFEROXAMINE; DNA FRAGMENT; GLUTATHIONE; MELPHALAN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL DEATH; CELL STRAIN HT29; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIOXIDANTS; APOPTOSIS; BUTHIONINE SULFOXIMINE; CELL CYCLE; CELL LINE; COLORECTAL NEOPLASMS; GLUTATHIONE; HT29 CELLS; HUMANS; MELPHALAN; TUMOR CELLS, CULTURED;

EID: 0033567420     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00130-6     Document Type: Article

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