Drug development train gathering steam

Nature Medicine

Volumn 2, Issue 4, 1996, Pages 403-404

  Ito, Takahiko ^a   May, W Stratford ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 4 CYANO ALPHA (3 INDOLYLMETHYLENE) 5 PYRAZOLEACETONITRILE; AG 1112; AG 568; BRYOSTATIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TYRPHOSTIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CELL GROWTH; CLINICAL TRIAL; DRUG SYNTHESIS; HUMAN; LEUKEMIA CELL LINE; NONHUMAN; NOTE; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

DRUG DESIGN; FORECASTING; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; NITRILES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TYRPHOSTINS;

EID: 0029944289     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0496-403     Document Type: Note

References (13)

1. Cortes, J.E. & Kantarjian, H.M. Acute lymphoblastic leukemia - a comprehensive review with emphasis on biology and therapy. Cancer 76, 2393-2417 (1995).
2. Ihle, J.N. Cytokine receptor signaling. Nature 377, 591-594 (1995).
3. Levitski, A. & Gazit, A. Tyrosine kinase inhibition: An approach to drug development. Science 267, 1782-1789 (1995).
4. Meydan, N. et al. Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor. Nature 379, 645-648 (1996).
5. Dvir, A. et al. The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers. J. Cell Biol. 113, 857-865 (1991).
6. Kaur, G. et al. Tyrphostin induced growth inhibition: Correlation with effect on p210 bcr-abl autokinase activity in K562 chronic myelogenous leukemia. Anticancer Drugs 5, 213-222 (1994).
7. Migone, T.S. et al. Constitutively activated Jak- STAT pathway in T cells transformed with HTLV-I. Science 269, 79-81 (1995).
8. Danial, N.N., Pernis, A. & Rothman, P.B. JakSTAT signaling induced by the v-abl oncogene. Science 269, 1875-1877(1995).
9. Karp, J.E. & Broder, S. New directions in molecular medicine. Cancer Res. 54, 653-665 (1994).
10. Gibbs, J.B., Oliff, A. & Kohl, N.E. Farnesyl-transferase inhibitors. Ras research yields a potential cancer therapeutic. Cell 77, 175-178 (1994).
11. James, G.L. et al. Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesy-lation in animal cells. Science 260, 1937-1942 (1993).
12. Jones, R.J. et al. Bryostatin 1, a unique biologic response modifier: Anti-leukemic activity in vitro. Blood 75, 1319-1323 (1990).
13. May, W.S. et al. Antineoplastic bryostatins are multipotential stimulators of human hemato-poietic progenitor cells. Proc. Natl. Acad. Sci. USA 84, 8483-8487 (1987).