A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line

Genes Chromosomes and Cancer

Volumn 18, Issue 4, 1997, Pages 254-268

  Suto, Yoshimasa ^a,b   Sato, Yuko ^a,c   Smith, Stephen D ^a   Rowley, Janet D ^a   Bohlander, Stefan K ^a,d  

^a UNIVERSITY OF CHICAGO   (United States)

^b HIROSAKI UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SUBSTITUTION; ARTICLE; B CELL LEUKEMIA; CELL LINE; CHILD; CHROMOSOME TRANSLOCATION 6; CONTROLLED STUDY; GENE FUSION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

STAPHYLOCOCCUS PHAGE 187;

EID: 0030945334     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-2264(199704)18:4<254::aid-gcc3>3.0.co;2-%23     Document Type: Article

References (35)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410.
2. Barker PE, Carroll AJ, Cooper MD (1987) t(1;19)(q23;p13) in pre-B acute lymphocytic leukemia cell line 697. Cancer Genet Cytogcnct 25:379-380.
3. Bohlander SK, Espinosa R, Fernald AA, Rowley JD, Le Beau MM, Díaz MO (1994) Sequence-independent amplification and labeling of yeast artificial chromosomes for fluorescence in situ hybridization. Cytogcnet Cell Genet 65:108-110.
4. Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A, Grosveld G (1995) Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 10:1511-1519.
5. Carle GF, Olson MV (1985) An electrophoretic karyotype for yeast. Proc Natl Acad Sci USA 82:3756-3760.
6. Cavé H, Gerard B, Martin E, Guidal C, Devaux I, Weissenbach J, Elion J, Vilmer E, Grandchamp B (1995) Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor-suppressor gene distinct from p27KIP1. Blood 86:3869-3875.
7. Chumakov I, Rigault P, Le Gall I, Bellane-Chantelot C, Billault A, Guillou S, Soularue P, Guasconi G, Poullier e, Gros I, Belova M, Sambucy J-L, susini L, Gervy P, Gilbert F, Beaufils S, Bui H, Massart C, De Tand M-F, Dukasz F, Lecoulant S, Ougen P, Perrot V, Saumler M, Soravito C, Bahouayila R, Cohen-Akenine A, Barillot E, Bertrand S, Codani J-J, Caterina D, I G, Lacroix B, Luctooe G, Sahbatou M, Schmit C, Sangouard M, Tubacher E, Dib C, Faure S, Fizames C, Gyapay G, Millasseou, P, NGuyen S, Muselet D, Vignal A, Morissette J, J M, Lieman J, Desai T, Banks A, Bray-Ward P, Ward D, Hudson T, Gerety S, Foote S, Stein L, Page DC, Lander ES, Weissenbach J, Le Paslier D, Cohen D (1995) A YAC contig map of the human genome. Nature 377:175-297.
8. Feinberg AP, Vogelstein B (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Annal Biochem 132:6-13.
9. Golub TR, Barker GF, Lovett M, Gilliland DG (1994a) Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myclomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307-316.
10. Golub TR, Barker BF, Bohlander SK, Stegmaier K, Bray-Ward P, Ward DC, Sato Y, Suto Y, Rowley JD, Gilliland DG (1994b) Evidence implicating the TEL gene at 12p13 in multiple mechanisms of leukemogenesis. Blood 84:229a.
11. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 92:4917-4921.
12. Hayashi Y, Raimondi SC, Look AT, Behm FG, Kitchingman GR, Pui CH, Rivera GK, Williams DL (1990) Abnormalities of the long arm of chromosome 6 in childhood acute lymphoblastic leukemia. Blood 76:1626-1630.
13. Hiebert SW, Sun W, Davis J, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussel MF, Gilliland DG, Lenny N, Meyers S (1996) The t(12:21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol 16:1349-1355.
14. Kim D-H, Moldwin in RL, Vibrion C, Bohlander SK, Suto Y, Giordano L, Gupta R, Fears S, Nucifora G, Rowley JD, Smith SD (1996) TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines. Blood in press.
15. Kobayashi H, Montgomery KT, Bohlander SK, Adra CN, Lim BL, Kucherlapati RS, Donis-Keller H, Holt MS, Le Beau MM, Rowley JD (1994) Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromsoome 12 in malignant hematologic diseases. Blood 88:785-794.
16. Le Beau MM (1991) Cytogenetic analysis of hematological malignant diseases. In M. J. Barch (ed): The ACT Cytogenetics Laboratory Manual. New York: Raven Press, Ltd., pp 395-445.
17. Nisson PE, Rashtchian A, Watkins PC (1991) Rapid and efficient cloning of Alu-PCR products using uracil DNA glycosylase. PCR Methods Appl 1:120-123.
18. Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM (1995) The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res 55:34-38.
19. Paulson KE, Deka N, Schmid CW, Misra R, Schindler CW, Rush MG, Kadyk L, Leinwand L (1985) A transposon-like element in human DNA. Nature 316:359-361.
20. Pietenpol JA, Bohlander SK, Sato Y, Papadopoulos N, Liu B, Friedman C, Trask BJ, Roberts JM, Kinzler KW, Rowley JD, Yogelstein B (1995) Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res 55:1206-1210.
21. Pizzuti A, Pieretti M, Fenwick RG, Gibbs RA, Caskey CT (1992) A transposon-like element in the deletion-prone region of the dystrophin gene. Genomics 13:594-600.
22. Pomykala HM, Bohlander SK, Broeker PL, Olopade OI, Diaz MO (1994) Breakpoint junctions of chromosome 9p deletions in two human glioma cell lines. Mol Cell Biol 14:7604-7610.
23. Raynaud S, Cave H, Baens M, Bastard C, Cacheux V, Grosgeorge J, Guidal-Giroux C, Guo C, Vilmer E, Marynen P, Grandchamp B (1996) The t(12;21) translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Blood 87:2891-2899.
24. Romana SP, Le Coniat M, Berger R (1994) t(12;21): A new recurrent translocation in acute lymphoblastic leukemia. Genes Chromosom Cancer 9:186-191.
25. Romana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA (1995a) The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662-3670.
26. Romana SP, Poirel H, Le Coniat M, Flexor M-A, Mauchauffe M, Jonveaux P, Macintyre EA, Berger R, Bernard OA (1995b) High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood 86:4265-1269.
27. Romana SP, Le Coniat M, Poirel H, Marynen P, Bernard OA, Berger R (1496) Deletion of the short arm of chromosome 12 is a secondary event in acute lymphoblastic leukemia with t(12;21). Leukemia 10:167-170.
28. Rowley JD (1990) Recurring chromosome abnormalities in leukemia and lymphoma. Sem Hematol 27:122-136.
29. Rowley JD, Díaz MO, Espinosa R, Patel YD, van Melle E, Ziemin S, Taillon-Miller P, Lichter P, Evans GA, Kersey JH, Ward DC, Domer PH, Le Beau MM (1990) Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: Identification of 11q23 translocation breakpoints with a yeast artificial chromosome. Proc Natl Acad Sci USA 97:9358-9362.
30. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467.
31. Sato Y, Suto Y, Pietenpol J, Golub TR, Gilliland DG, Davis EM, Le Beau MM, Roberts JM, Vogelstein B, Rowley JD, Bohlander SK (1995) TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies. Blood 86:1525-1533.
32. Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC-F, Pui C-H, Grosveld G, Downing JR (1995) Tel/AML1 fusion resulting from a cryptic t(12:21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia 9:1985-1989.
33. Stegmaier K, Pendse S, Barker GF, Bray-Ward P, Ward DC, Montgomery KT, Krauter KS, Reynolds C, Sklar J, Donnelly M, Bohlander SK, Rowley JD, Sallan SE, Gilliland DG, Golub TR (1995) Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood. Blood 86:38-44.
34. Takeuchi S, Bartram CR, Wada M, Reiter A, Hatta Y, Seriu T, Lee E, Miller CW, Miyoshi I, Koeffler HP (1995) Allelotype analysis of childhood acute lymphoblastic leukemia. Cancer Res 55:5377-5782.
35. Zhang LQ, Downie PA, Goodell WR, McCabe NR, LeBeau MM, Morgan R, Sklar J, Raimondi SC, Miley D, Goldberg A, Lu M-M, Montag A, Smith SD (1993) Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia. Leukemia 7:1865-1874.