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Volumn 162, Issue 4, 1999, Pages 2217-2226

IL-12 administered during Chlamydia psittaci lung infection in mice confers immediate and long-term protection and reduces macrophage inflammatory protein-2 level and neutrophil infiltration in lung tissue

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033557686     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (56)

References (58)
  • 4
    • 0028805751 scopus 로고
    • Gene knockout mice establish a primary protective role for major histocompatibility complex class 11-restricted responses in Chlamydia trachomatis genital tract infection
    • Morrison, R. P., K. Feilzer, and D. B. Tumas. 1995. Gene knockout mice establish a primary protective role for major histocompatibility complex class 11-restricted responses in Chlamydia trachomatis genital tract infection. Infect. Immun. 63:4661.
    • (1995) Infect. Immun. , vol.63 , pp. 4661
    • Morrison, R.P.1    Feilzer, K.2    Tumas, D.B.3
  • 5
    • 0001489976 scopus 로고
    • Overview of human diseases
    • A.L. Barron, ed. CRC Press, Boca Raton
    • Schachter, J. 1988. Overview of human diseases. In Microbiology of Chlamydia. A.L. Barron, ed. CRC Press, Boca Raton, p. 153.
    • (1988) Microbiology of Chlamydia , pp. 153
    • Schachter, J.1
  • 6
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145
    • Mosmann, T.R.1    Coffman, R.L.2
  • 7
    • 0029976591 scopus 로고    scopus 로고
    • Genetically determined differences in IL-10 and IFN-γ responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection
    • Yang, X., K. T. HayGlass, and R. C. Brunham. 1996. Genetically determined differences in IL-10 and IFN-γ responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection. J. Immunol. 156:4338.
    • (1996) J. Immunol. , vol.156 , pp. 4338
    • Yang, X.1    HayGlass, K.T.2    Brunham, R.C.3
  • 8
    • 0031112653 scopus 로고    scopus 로고
    • Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-γ-dependent and -independent pathways
    • Perry, L. L., K. Feilzer, and H. D. Caldwell. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-γ-dependent and -independent pathways. J. Immunol. 158:3344.
    • (1997) J. Immunol. , vol.158 , pp. 3344
    • Perry, L.L.1    Feilzer, K.2    Caldwell, H.D.3
  • 9
    • 0030951306 scopus 로고    scopus 로고
    • Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis
    • Williams, D. M., B. G. Grubbs, E. Pack, K. Kelly, and R. G. Rank. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect. Immun. 65:2876.
    • (1997) Infect. Immun. , vol.65 , pp. 2876
    • Williams, D.M.1    Grubbs, B.G.2    Pack, E.3    Kelly, K.4    Rank, R.G.5
  • 10
    • 0027884892 scopus 로고
    • Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone
    • Igietseme, J. U., K. H. Ramsey, D. M. Magee, D. M. Williams, T. J. Kincy, and R. G. Rank. 1993. Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone. Reg. Immunol. 5:317.
    • (1993) Reg. Immunol. , vol.5 , pp. 317
    • Igietseme, J.U.1    Ramsey, K.H.2    Magee, D.M.3    Williams, D.M.4    Kincy, T.J.5    Rank, R.G.6
  • 11
    • 0029973242 scopus 로고    scopus 로고
    • Immunoregulation by interleukin-12
    • Trinchieri, G., and F. Gerosa. 1996. Immunoregulation by interleukin-12. J. Leukocyte Biol. 59:505.
    • (1996) J. Leukocyte Biol. , vol.59 , pp. 505
    • Trinchieri, G.1    Gerosa, F.2
  • 12
    • 0029967256 scopus 로고    scopus 로고
    • Inlerleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor α and γ interferon
    • Hunter, C. A., T. Slifer, and F. Araujo. 1996. Inlerleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor α and γ interferon. Infect. Immun. 64:2381.
    • (1996) Infect. Immun. , vol.64 , pp. 2381
    • Hunter, C.A.1    Slifer, T.2    Araujo, F.3
  • 13
    • 0029166460 scopus 로고
    • Early parasite containment is decisive for resistance to Leishmania major infection
    • Laskay, T., A. Diefenbach, M. Roellinghoff, and W. Solbach. 1995. Early parasite containment is decisive for resistance to Leishmania major infection. Eur. J. Immunol. 25:2220.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2220
    • Laskay, T.1    Diefenbach, A.2    Roellinghoff, M.3    Solbach, W.4
  • 14
    • 0013954217 scopus 로고
    • Psittacosis-lymphogranuloma infection of sheep: Antigenic structures and interrelations of PL agents associated with polyarthritis, enzootic abortion, intrauterine and latent intestinal infections
    • Storz, J. 1966. Psittacosis-lymphogranuloma infection of sheep: antigenic structures and interrelations of PL agents associated with polyarthritis, enzootic abortion, intrauterine and latent intestinal infections. J. Comp. Pathol. 76:351.
    • (1966) J. Comp. Pathol. , vol.76 , pp. 351
    • Storz, J.1
  • 15
    • 0002696415 scopus 로고
    • Diversity of Chlamydia-induced diseases
    • Z. Woldehiwet and M. Ristic. eds. Pergamon Press, Oxford
    • Storz, J., and B. Kaltenboeck. 1993. Diversity of Chlamydia-induced diseases. In Rickettsial and Chlamydial Diseases of Domestic Animals. Z. Woldehiwet and M. Ristic. eds. Pergamon Press, Oxford, p. 363.
    • (1993) Rickettsial and Chlamydial Diseases of Domestic Animals , pp. 363
    • Storz, J.1    Kaltenboeck, B.2
  • 16
    • 0031111517 scopus 로고    scopus 로고
    • Gestational psittacosis in a Montana sheep rancher
    • Jorgensen, D. M. 1997. Gestational psittacosis in a Montana sheep rancher. Emerg. Infect. Dis. 3:191.
    • (1997) Emerg. Infect. Dis. , vol.3 , pp. 191
    • Jorgensen, D.M.1
  • 17
    • 0027510211 scopus 로고
    • Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species
    • Kaltenboeck, B., K. G. Kousoulas, and J. Storz. 1993. Structures of and allelic diversity and relationships among the major outer membrane protein (ompA) genes of the four chlamydial species. J. Bacteriol. 175:487.
    • (1993) J. Bacteriol. , vol.175 , pp. 487
    • Kaltenboeck, B.1    Kousoulas, K.G.2    Storz, J.3
  • 18
    • 0026704611 scopus 로고
    • Efficient culture of Chlamydia pneumoniae with cell lines derived from the human respiratory tract
    • Wong, K. H., S. K. Skelton, and Y. K. Chan. 1992. Efficient culture of Chlamydia pneumoniae with cell lines derived from the human respiratory tract. J. Clin. Microbiol. 30:1625.
    • (1992) J. Clin. Microbiol. , vol.30 , pp. 1625
    • Wong, K.H.1    Skelton, S.K.2    Chan, Y.K.3
  • 19
    • 18144450781 scopus 로고
    • Comparative investigations with Buffalo Green Monkey (BGM) cells and mice on the isolation of Chlamydia psittaci from fecal and organ specimens of birds
    • Arens, M., and M. Weingarten. 1981. Comparative investigations with Buffalo Green Monkey (BGM) cells and mice on the isolation of Chlamydia psittaci from fecal and organ specimens of birds. J. Vet. Med. 28:301.
    • (1981) J. Vet. Med. , vol.28 , pp. 301
    • Arens, M.1    Weingarten, M.2
  • 20
    • 0019514724 scopus 로고
    • Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis
    • Caldwell, H. D., J. Kromhout, and J. Schachter. 1981. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect. Immun. 31:1161.
    • (1981) Infect. Immun. , vol.31 , pp. 1161
    • Caldwell, H.D.1    Kromhout, J.2    Schachter, J.3
  • 21
    • 0026802888 scopus 로고
    • Establishment of a particle-counting method for purified elementary bodies of chlamydiae and evaluation of sensitivities of the IDEIA Chlamydia kit and DNA probe by using the purified elementary bodies
    • Miyashita, N., and A. Matsumoto. 1992. Establishment of a particle-counting method for purified elementary bodies of chlamydiae and evaluation of sensitivities of the IDEIA Chlamydia kit and DNA probe by using the purified elementary bodies. J. Clin. Microbiol. 10:2911.
    • (1992) J. Clin. Microbiol. , vol.10 , pp. 2911
    • Miyashita, N.1    Matsumoto, A.2
  • 22
    • 0001356501 scopus 로고
    • The influence of certain salts, amino acids, sugars, and proteins on the stability of Rickettsiae
    • Bovarnick, M. R., J. C. Miller, and J. C. Snyder. 1950. The influence of certain salts, amino acids, sugars, and proteins on the stability of Rickettsiae. Stability of Rickettsiae 59:509.
    • (1950) Stability of Rickettsiae , vol.59 , pp. 509
    • Bovarnick, M.R.1    Miller, J.C.2    Snyder, J.C.3
  • 23
    • 0342397461 scopus 로고
    • In vivo assays for mouse lymphocyte function: Delayed-type hypersensilivity
    • J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Greene Publishing Associates, New York
    • Luo, Y., and M. E. Dorf. 1992. In vivo assays for mouse lymphocyte function: delayed-type hypersensilivity. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Greene Publishing Associates, New York, p. 4.5.1.
    • (1992) Current Protocols in Immunology , pp. 451
    • Luo, Y.1    Dorf, M.E.2
  • 25
    • 0029856309 scopus 로고    scopus 로고
    • Chemokine receptors: Gateways to inflammation and infection
    • Premack, B. A., and T. J. Schall. 1996. Chemokine receptors: gateways to inflammation and infection. Nat. Med. 2:1174.
    • (1996) Nat. Med. , vol.2 , pp. 1174
    • Premack, B.A.1    Schall, T.J.2
  • 26
    • 0030140458 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1: A potential regulator of monocyte recruitment in inflammatory disease
    • Rollins, B. J. 1996. Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease. Mol. Med. Today 2:198.
    • (1996) Mol. Med. Today , vol.2 , pp. 198
    • Rollins, B.J.1
  • 29
    • 0029934075 scopus 로고    scopus 로고
    • Human natural killer cells produce abundant macrophage inflammatory protein-1α in response to monocyte-derived cytokines
    • Bluman, E. M., K. J. Bartynski, B. R. Avalos, and M. A. Caliguri. 1996. Human natural killer cells produce abundant macrophage inflammatory protein-1α in response to monocyte-derived cytokines. J. Clin. Invest. 97:2722.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2722
    • Bluman, E.M.1    Bartynski, K.J.2    Avalos, B.R.3    Caliguri, M.A.4
  • 31
    • 0030613627 scopus 로고    scopus 로고
    • MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelilis as well as Th1/Th2 lymphocyte differentiation
    • Karpus, W. J., and K. J. Kennedy. 1997. MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelilis as well as Th1/Th2 lymphocyte differentiation. J. Leukocyte Biol. 62:681.
    • (1997) J. Leukocyte Biol. , vol.62 , pp. 681
    • Karpus, W.J.1    Kennedy, K.J.2
  • 32
    • 0028803841 scopus 로고
    • High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens
    • Rutledge, B. J., H. Rayburn, R. Rosenberg, R. J. North, R. P. Gladue, C. L. Corless, and B. J. Rollins. 1995. High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J. Immunol. 155:4838.
    • (1995) J. Immunol. , vol.155 , pp. 4838
    • Rutledge, B.J.1    Rayburn, H.2    Rosenberg, R.3    North, R.J.4    Gladue, R.P.5    Corless, C.L.6    Rollins, B.J.7
  • 33
    • 0032473406 scopus 로고    scopus 로고
    • Monocyte chemolactic protein 1 protein regulates oral tolerance induction by inhibition of T helper cell-related cytokines
    • Karpus, W. J., K. J. Kennedy, S. L. Kunkel, and N. W. Lukacs. 1998. Monocyte chemolactic protein 1 protein regulates oral tolerance induction by inhibition of T helper cell-related cytokines. J. Exp. Med. 187:733.
    • (1998) J. Exp. Med. , vol.187 , pp. 733
    • Karpus, W.J.1    Kennedy, K.J.2    Kunkel, S.L.3    Lukacs, N.W.4
  • 34
    • 0028943066 scopus 로고
    • Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α
    • Flesch, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181:1615.
    • (1995) J. Exp. Med. , vol.181 , pp. 1615
    • Flesch, I.E.A.1    Hess, J.H.2    Huang, S.3    Aguet, M.4    Rothe, J.5    Bluethmann, H.6    Kaufmann, S.H.E.7
  • 35
    • 0029099391 scopus 로고
    • Effects of IL-12 on immune responses to microbial infections: A key mediator in regulating disease outcome
    • Biron, C. A., and R. T. Gazzinelli. 1995. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7:485.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 485
    • Biron, C.A.1    Gazzinelli, R.T.2
  • 36
    • 0031058331 scopus 로고    scopus 로고
    • Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ)
    • Trinchieri, G. 1997. Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ). Curr. Opin. Immunol. 9:17.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 17
    • Trinchieri, G.1
  • 37
    • 0026700173 scopus 로고
    • Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor α required as a costimulatory factor for interferon γ-induced activation
    • Oswald, I. P., T. A. Wynn, A. Sher, and S. L. James. 1992. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor α required as a costimulatory factor for interferon γ-induced activation. Proc. Natl. Acad. Sci. USA 89:8676.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8676
    • Oswald, I.P.1    Wynn, T.A.2    Sher, A.3    James, S.L.4
  • 39
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogeneous T helper cell subsets
    • O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275.
    • (1998) Immunity , vol.8 , pp. 275
    • O'Garra, A.1
  • 40
    • 0031045567 scopus 로고    scopus 로고
    • Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance
    • Unanue, E. R. 1997. Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance. Curr. Opin. Immunol. 9:35.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 35
    • Unanue, E.R.1
  • 41
    • 0027177008 scopus 로고
    • IL-12: Initiation cytokine for cell-mediated immunity
    • Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496.
    • (1993) Science , vol.260 , pp. 496
    • Scott, P.1
  • 42
    • 0028950126 scopus 로고
    • Interleukin 12 is effective treatment for an established systemic intracellular infection: Experimental visceral Leishmaniasis
    • Murray, H. W., and J. Hariprashad. 1995. Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral Leishmaniasis. J. Exp. Med. 181:387.
    • (1995) J. Exp. Med. , vol.181 , pp. 387
    • Murray, H.W.1    Hariprashad, J.2
  • 43
    • 0029078676 scopus 로고
    • IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection
    • Flynn, J. L., M. M. Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155:2515.
    • (1995) J. Immunol. , vol.155 , pp. 2515
    • Flynn, J.L.1    Goldstein, M.M.2    Triebold, K.J.3    Sypek, J.4    Wolf, S.5    Bloom, B.R.6
  • 44
    • 0030051658 scopus 로고    scopus 로고
    • Regulation of murine macrophage IL-12 production activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
    • Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1196.
    • (1996) J. Immunol. , vol.156 , pp. 1196
    • Skeen, M.J.1    Miller, M.A.2    Shinnick, T.M.3    Ziegler, H.K.4
  • 46
    • 0000060327 scopus 로고    scopus 로고
    • In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
    • e Sousa, C. R., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R. N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med 186:1819.
    • (1997) J. Exp. Med , vol.186 , pp. 1819
    • E Sousa, C.R.1    Hieny, S.2    Scharton-Kersten, T.3    Jankovic, D.4    Charest, H.5    Germain, R.N.6    Sher, A.7
  • 47
    • 0029077326 scopus 로고
    • IL-12 is required for natural killer cell activation and subsequent T helper cell 1 development in experimental leishmaniasis
    • Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper cell 1 development in experimental leishmaniasis. J. Immunol. 154:5320.
    • (1995) J. Immunol. , vol.154 , pp. 5320
    • Scharton-Kersten, T.1    Afonso, L.C.C.2    Wysocka, M.3    Trinchieri, G.4    Scott, P.5
  • 48
    • 0031019163 scopus 로고    scopus 로고
    • Activation and function of natural killer cell responses during viral infections
    • Biron, C. A. 1997. Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9:24.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 24
    • Biron, C.A.1
  • 49
    • 0029096181 scopus 로고
    • Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
    • Orange, J. S., B. Wang, C. Terhorst, and C. A. Biron. 1995. Requirement for natural killer cell-produced Interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:1045.
    • (1995) J. Exp. Med. , vol.182 , pp. 1045
    • Orange, J.S.1    Wang, B.2    Terhorst, C.3    Biron, C.A.4
  • 51
    • 0030790652 scopus 로고    scopus 로고
    • Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
    • Cooper, A. M., J. Magram, J. Ferrante, and I. M. Orme. 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J. Exp. Med. 186:39.
    • (1997) J. Exp. Med. , vol.186 , pp. 39
    • Cooper, A.M.1    Magram, J.2    Ferrante, J.3    Orme, I.M.4
  • 52
    • 0030754339 scopus 로고    scopus 로고
    • Ablation of interleukin-12 exacerbates arthritis in SCID mice
    • Anguita, J., S. Samanta, S. W. Barthold, and E. Fikrig. 1997. Ablation of interleukin-12 exacerbates arthritis in SCID mice. Infect. Immun. 65:4334.
    • (1997) Infect. Immun. , vol.65 , pp. 4334
    • Anguita, J.1    Samanta, S.2    Barthold, S.W.3    Fikrig, E.4
  • 54
    • 0030699387 scopus 로고    scopus 로고
    • Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor
    • Kurihara, T., G. Warr, J. Loy, and R. Bravo. 1997. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J. Exp. Med. 186:1757
    • (1997) J. Exp. Med. , vol.186 , pp. 1757
    • Kurihara, T.1    Warr, G.2    Loy, J.3    Bravo, R.4
  • 55
    • 0030588642 scopus 로고    scopus 로고
    • Role of monocyte chemoattraclant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation
    • Chensue, S. W., K. S. Warmington, J. H. Ruth, P. S. Sanghi, P. Lincoln, and S. L. Kunkel. 1996. Role of monocyte chemoattraclant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation. J. Immunol. 157:4602.
    • (1996) J. Immunol. , vol.157 , pp. 4602
    • Chensue, S.W.1    Warmington, K.S.2    Ruth, J.H.3    Sanghi, P.S.4    Lincoln, P.5    Kunkel, S.L.6
  • 57
    • 0028877056 scopus 로고
    • Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
    • Openshaw, P., E. E. Murphy, N. A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182: 1357.
    • (1995) J. Exp. Med. , vol.182 , pp. 1357
    • Openshaw, P.1    Murphy, E.E.2    Hosken, N.A.3    Maino, V.4    Davis, K.5    Murphy, K.6    O'Garra, A.7
  • 58
    • 0031573221 scopus 로고    scopus 로고
    • Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response
    • Hondowicz, B. D., T. M. Scharton-Kersten, D. E. Jones, and P. Scott. 1997. Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response. J. Immunol. 159:5024.
    • (1997) J. Immunol. , vol.159 , pp. 5024
    • Hondowicz, B.D.1    Scharton-Kersten, T.M.2    Jones, D.E.3    Scott, P.4


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