Conditional activation defect of a human Gsα mutant

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 11, 1997, Pages 5656-5661

  Iiri, Taroh ^a   Farfel, Zvi ^b   Bourne, Henry R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Conformational change; Gs; Guanosine triphosphate; Pseudohypoparathyroidism; Trimeric G proteins

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; HORMONAL REGULATION; HORMONE RESPONSE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN INDUCTION; PSEUDOHYPOPARATHYROIDISM;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; ARGININE; CELL LINE; CONSERVED SEQUENCE; CYCLIC AMP; GLUTAMIC ACID; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; ISOPROTERENOL; KINETICS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT FUSION PROTEINS; SPODOPTERA; TRANSFECTION;

EID: 0030903692     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.11.5656     Document Type: Article

References (38)

1. Conklin, B. R. & Bourne, H. R. (1993) Cell 73, 631-641.
2. Gilman, A. G. (1987) Annu. Rev. Biochem. 56, 615-649.
3. Noel, J. P., Hamm, H. E. & Sigler, P. B. (1993) Nature (London) 366, 654-663.
4. Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. (1994) Nature (London) 369, 621-628.
5. Mixon, M. B., Lee, E., Coleman, D. E., Berghuis, A. M., Oilman, A. G. & Sprang, S. R. (1995) Science 270, 954-960.
6. Brandt, D. R. & Ross, E. M. (1986) J. Biol. Chem. 261, 1656-1664.
7. Florio, V. A. & Sternweis, P. C. (1989) J. Biol. Chem. 264, 3409-3915.
8. Hepler, J. R., Kozasa, T., Smrcka, A. V., Simon, M. I., Rhee, S. G., Sternweis, P. C. & Oilman, A. G. (1993) J. Biol. Chem. 268, 14367-14375.
9. Singer, W. D., Miller, R. T. & Sternweis, P. C. (1994) J. Biol. Chem. 269, 19796-19802.
10. Berstein, G., Blank, J. L., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H. & Ross, E. M. (1992) J. Biol. Chem. 267, 8081-8088.
11. Farfel, Z., Iiri, T., Shapira, H., Roitman, Z., Mouallem, M. & Bourne, H. R. (1996) J. Biol. Chem. 271, 19653-19655.
12. Levis, M. J. & Bourne, H. R. (1992) J. Cell Biol. 119, 1297-1307.
13. Iiri, T., Herzmark, P., Nakamoto, J. M., Van Dop, C. & Bourne, H. R. (1994) Nature (London) 371, 164-168.
14. von Zastrow, M. & Kobilka, B. K. (1992) J. Biol. Chem. 267, 3530-3538.
15. Wedegaertner, P. B., Bourne, H. R. & von Zastrow, M. (1996) Mol. Biol. Cell 7, 1225-1233.
16. Garcia, P. D., Onrust, R., Bell, S. M., Sakmar, T. P. & Bourne, H. R. (1995) EMBO J. 14, 4460-4469.
17. Iiri, T., Homma, Y., Ohoka, Y., Robishaw, J. D., Katada, T. & Bourne, H. R. (1995) J. Biol. Chem. 270, 5901-5908.
18. Iiri, T., Backlund, P. B., Jones, T. L. Z., Wedegaertner, P. B. & Bourne, H. R. (1996) Proc. Natl. Acad. Sci. USA 93, 14592-14597.
19. Graziano, M. P., Freissmuth, M. & Gilman, A. G. (1989) J. Biol. Chem. 264, 409-418.
20. Iiri, T., Ohoka, Y., Ui, M. & Katada, T. (1992) J. Biol. Chem. 267, 1020-1026.
21. Wong, Y. H., Federman, A., Pace, A. M., Zachary, I., Evans, T., Pouysségur, J. & Bourne, H. R. (1991) Nature (London) 351, 63-65.
22. Bourne, H. R., Kaslow, D., Kaslow, H. R., Salomon, M. R. & Licko, V. (1981) Mol. Pharmacol. 20, 435-441.
23. Miller, R. T., Masters, S. B., Sullivan, K. A., Beiderman, B. & Bourne, H. R. (1988) Nature (London) 334, 712-715.
24. Haga, K., Haga, T. & Ichiyama, A. (1986) J. Biol. Chem. 261, 10133-10140.
25. Coleman, D. E., Berghuis, A. M., Lee, E., Linder, M. E., Gilman, A. G. & Sprang, S. R. (1994) Science 265, 1405-1412.
26. Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. (1994) Nature (London) 372, 276-279.
27. Stratton, H. F., Zhou, J., Reed, S. I. & Stone, D. E. (1996) Mol. Cell. Biol. 16, 6325-6337.
28. Lambright, D. G., Sondek, J., Bohm, A., Skiba, N. P., Hamm, H. E. & Sigler, P. B. (1996) Nature (London) 379, 311-9.
29. Lichtarge, O., Bourne, H. R. & Cohen, F. E. (1996) Proc. Natl. Acad. Sci. USA 93, 7507-7511.
30. Onrust, R., Herzmark, P., Chi, P., Garcia, P. D., Lichtarge, O., Kingsley, C. & Bourne, H. R. (1997) Science 275, 381-384.
31. Cassel, D. & Selinger, Z. (1977) Proc. Natl. Acad. Sci. USA 74, 3307-3311.
32. Cassel, D. & Selinger, Z. (1977) J. Cyclic Nucleotide Res. 3, 11-22.
33. Farfel, Z. & Bourne, H. R. (1982) Miner. Electrolyte Metab. 8, 227-236.
34. Spiegel, A. M., Shenker, A. & Weinstein, L. S. (1992) Endocr. Rev. 13, 536-565.
35. Ringel, M. D., Schwindinger, W. F. & Levine, M. A. (1996) Medicine (Baltimore) 75, 171-184.
36. Farfel, Z., Brickman, A. S., Kaslow, H. R., Brothers, V. M. & Bourne, H. R. (1980) N. Engl. J. Med. 303, 237-242.
37. Levine, M. A., Downs, R. W., Jr., Singer, M., Marx, S. J., Aurbach, G. D. & Spiegel, A. M. (1980) Biochem. Biophys. Res. Commun. 94, 1319-1324.
38. Farfel, Z., Brothers, V. M., Brickman, A. S., Conte, F., Neer, R. & Bourne, H. R. (1981) Proc. Natl. Acad. Sci. USA 78, 3098-3102.