NK and CTL recognition of a single chain H-2D(d) molecule: Distinct sites of H-2D(d) interact with NK and TCR

Journal of Immunology

Volumn 163, Issue 7, 1999, Pages 3699-3708

  Chung, Doo Hyun ^a   Dorfman, Jeffrey ^a   Plaksin, Daniel ^a,d   Natarajan, Kannan ^a   Belyakov, Igor M ^b   Hunziker, Rosemarie ^a,e   Berzofsky, Jay A ^b   Yokoyama, Wayne M ^c   Mage, Michael G ^b   Margulies, David H ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Peptor Ltd   (Israel)

^e NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; CYTOTOXIC T LYMPHOCYTE; KNOCKOUT MOUSE; MOLECULAR INTERACTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, LY; BETA 2-MICROGLOBULIN; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOTOXICITY, IMMUNOLOGIC; H-2 ANTIGENS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES, CYTOTOXIC; TRANSGENES; VACCINIA VIRUS;

EID: 0010198034     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. Liao, N. S., M. Bix, M. Zijlstra, R. Jaenisch, and D. Raulet. 1991. MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science 253:199.
2. - bone marrow in chimeric mice. Proc. Natl. Acad. Sci. USA 88:10332.
3. + cytolytic T cells. Nature 344:742.
4. + T cells. Science 248:1227.
5. Valiante, N. M., and P. Parham. 1996. NK cells and CTL: opposite sides of the same coin. Chem. Immunol. 64:146.
6. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
7. Jorgensen, J. L., P. A. Reay, E. W. Ehrich, and M. M. Davis. 1992. Molecular components of T-cell recognition. Annu. Rev. Immunol. 10:835.
8. + T cells in the thymus. Cell 73:1041.
9. Correa, I., and D. H. Raulet. 1995. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity 2:61.
10. Salcedo, M., P. Höglund, A. Achour, C. J. Thorpe, and H. G. Ljunggren. 1995. Altered MHC class I presented peptide repertoire is not sufficient to induce NK cell mediated F-1-hybrid resistance. Mol. Immunol. 32:789.
11. Orihuela, M., D. H. Margulies, and W. M. Yokoyama. 1996. The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. Proc. Natl. Acad. Sci. USA 93:11792.
12. Malnati, M. S., M. Peruzzi, K. C. Parker, W. E. Biddison, E. Ciccone, A. Moretta, and E. O. Long. 1995. Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science 267:1016.
13. Rajagopalan, S., and E. O. Long. 1997. The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. J. Exp. Med. 185:1523.
14. Lanier, L. L. 1998. NK cell receptors. Annu. Rev. Immunol. 16:359.
15. + IL-2-activated natural killer cells. Nature 358: 66.
16. Mason, L. H., J. R. Ortaldo, H. A. Young, V. Kumar, M. Bennett, and S. K. Anderson. 1995. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). J. Exp. Med 182:293.
17. Stoneman, E. R., M. Bennett, J. An, K. A. Chesnut, E. K. Wakeland, J. B. Scheerer, M. J. Siciliano, V. Kumar, and P. A. Mathew. 1995. Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells. J. Exp. Med. 182:305.
18. Karlhofer, F. M., R. Hunziker, A. Reichlin, D. H. Margulies, and W. M. Yokoyama. 1994. Host MHC class I molecules modulate in vivo expression of a NK cell receptor. J. Immunol. 153:2407.
19. Held, W., J. R. Dorfman, M. F. Wu, and D. H. Raulet. 1996. Major histocompatibility complex class I-dependent skewing of the natural killer cell Ly49 receptor reportoire. Eur. J. Immunol. 26:2286.
20. low NK cells. J. Immunol. 159:3189.
21. Salcedo, M., A. D. Diehl, M. Y. Olsson-Alheim, J. Sundbäck, L. Van Kaer, K. Kärre, and H. G. Ljunggren. 1997. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J. Immunol. 158:3174.
22. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A. Wilson. 1996. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science 274:209.
23. Garboczi, D. N., P. Ghosh, U. Utz, Q. R. Fan, W. E. Biddison, and D. C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 384:134.
24. Wilson, I. A., and K. C. Garcia. 1997. T-cell receptor structure and TCR complexes. Curr. Opin. Struct. Biol. 7:839.
25. Garcia, K. C., M. Degano, L. R. Pease, M. Huang, P. A. Peterson, L. Teyton, and I. A. Wilson. 1998. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 279:1166.
26. Ding, Y. H., K. J. Smith, D. N. Garboczi, U. Utz, W. E. Biddison, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403.
27. Yokoyama, W. M., and W. E. Seaman. 1993. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11:613.
28. Daniels, B. F., F. M. Karlhofer, W. E. Seaman, and W. M. Yokoyama. 1994. A natural killer cell receptor specific for a major histocompatibility complex class 1 molecule. J. Exp. Med. 180:687.
29. Kane, K. P. 1994. Ly-49 mediates EL4 lymphoma adhesion to isolated class I major histocompalibility complex molecules. J. Exp. Med. 179:1011.
30. Brennan, J., D. Mager, W. Jefferies, and F. Takei. 1994. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J. Exp. Med. 180:2287.
31. d, has a functional carbohydrate recognition domain. Immunity 1:785.
32. Mage, M. G., L. Lee, R. K. Ribaudo, M. Corr, S. Kozlowski, L. McHugh, and D. H. Margulies. 1992. A recombinant, soluble, single-chain class I major histocompatibility complex molecule with biological activity. Proc. Natl. Acad. Sci. USA 89:10658.
33. 2-microglobulin domain. Eur. J. Immunol. 24:2633.
34. 2-microglobulin domain, is biologically active in peptide binding and antigen presentation. Hum. Immunol. 49:28.
35. d. Eur. J. Immunol. 23:1776.
36. 2m double knockout mice. J. Exp. Med. 185:2043.
37. Takahashi, H., J. Cohen, A. Hosmalin, K. Cease, R. Houghten, J. Cornette, C. DeLisi, B. Mosys, R. Germain, and J. Berzofsky. 1988. An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 85:3105.
38. Shirai, M., C. D. Pendleton, and J. A. Berzofsky. 1992. Broad recognition of cytotoxic T cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules. J. Immunol. 148:1657.
39. 2 helix of an MHC class I molecule by a valine to proline mutation in position 165 does not prevent peptide-specific antigen presentation, J. Immunol. 159:4408.
40. Evans, G., D. Margulies, B. Shykind, J. Seidman, and K. Ozato. 1982. Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens. Nature 300:755.
41. d mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer. J. Immunol. 130:463.
42. Bieberich, C., G. Scangos, K. Tanaka, and G. Jay. 1986 Regulated expression of a murine class I gene in transgenic mice. Mol. Cell Biol. 6:1339.
43. Altin, J. G., and E. B. Pagler. 1995. A one-step procedure for biotinylation and chemical cross-linking of lymphocyte surface and intracellular membrane-associated molecules. Anal. Biochem. 224:382.
44. Earl, P. L., A. W. Hugin, and B. Moss. 1990. Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus. J. Virol. 64:2448.
45. Belyakov, I. M., M. A. Derby, J. D. Ahlers, B. L. Kelsall, P. Earl, B. Moss, W. Strober, and J. A. Berzofsky. 1998. Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge. Proc. Natl. Acad. Sci. USA 95:1709.
46. Raulet, D. H., P. D. Gottlieb, and M. J. Bevan. 1980. Fractionation of lymphocyte populations with monoclonal antibodies specific for LYT-2.2 and LYT-3.1. J. Immunol. 125:1136.
47. Chadwick, B. S., S. R. Sambhara, Y. Sasakura, and R. G. Miller. 1992. Effect of class I MHC binding peptides on recognition by natural killer cells. J. Immunol. 149:3150.
48. 2 microglobulin. J. Exp. Med. 160:317.
49. 2-microglobulin. Proc. Natl. Acad. Sci. USA 82:2950.
50. 2 microglobulin negative cells. J. Exp. Med. 176:829.
51. McCluskey, J., J. Bluestone, J. Coligan, W. Maloy, and D. Margulies. 1986. Serologic and T cell recognition of truncated transplantation antigens encoded by in vitro deleted class I major histocompatibility genes. J. Immunol. 136:1472.
52. + T cells. Cell 71:1205.
53. Öhlén, C., G. Kling, P. Hoglund, M. Hansson, G. Scangos, C. Bieberich, G. Jay, and K. Kärre. 1989. Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice. Science 246:666.
54. Hoglund, P., R. Glas, C. Óhlën, H. G. Ljunggren, and K. Kärre. 1991. Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target. J. Exp. Med. 174:327.
55. Bix, M., N. S. Liao, M. Zijlstra, J. Loring, R. Jaenisch, and D. Raulet. 1991. Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature 349:329.
56. Held, W., D. Cado, and D. H. Raulet. 1996. Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. J. Exp. Med. 184:2037.
57. Ljunggren, H. G., and K. Kärre. 1990. In search of the 'missing self: MHC molecules and NK cell recognition. Immunol. Today 11:237.
58. George, T. C., L. H. Mason, J. R. Ortaldo, V. Kumar, and M. Bennett. 1999. Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells. J. Immunol. 162:2015.
59. d and activates natural killer cell cytotoxicity. J. Exp. Med. 189:493.
60. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
61. + thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity 6:401.
62. Fung-Leung, W. P., C. D. Surh, M. Liljedahl, J. Pang, D. Leturcq, P. A. Peterson, S. R. Webb, and L. Karlsson. 1996. Antigen presentation and T cell development in H2-M-deficient mice. Science 271:1278.
63. Miyazaki, T., P. Wolf, S. Tourne, C. Waltzinger, A. Dierich, N. Barois, H. Ploegh, C. Benoisl, and D. Mathis. 1996. Mice lacking H2-M complexes, enigmatic elements of the MHC class 11 peptide-loading pathway. Cell 84:531.
64. 0/0 mice. Immunity 7:187.
65. Lee, L., L. McHugh, S. Sakuma, D. Loftus, E. Appella, D. H. Margulies, and M. Mage. 1995. Peptide-loaded recombinant single-chain HLA molecules as potential immunogens for T cells. In Vaccines 95. F. Brown, R. Chanock, H. S. Ginsburg, and E. Norby, eds, Cold Spring Harbor, New York, p. 243.
66. Braud, V. M., D. S. Allan, C. A. O'Callaghan, K. Soderstrom, A. D'Andrea, G. S. Ogg, S. Lazetic, N. T. Young, J. I. Bell, J. H. Phillips, L. L. Lanier, and A. J. McMichael. 1998. HLA-E binds to natural killer cell receptors CD94/ NKG2A, B and C. Nature 391:795.
67. Borrego, F., M. Ulbrecht, E. H. Weiss, J. E. Coligan, and A. G. Brooks. 1998. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J. Exp. Med. 187:813.
68. Vance, R. E., and D. H. Raulet. 1998. Toward a quantitative analysis of the repertoire of class I MHC-specific inhibitory receptors on natural killer cells. Curr. Top. Microbiol. Immunol. 230:135.
69. Vance, R. E., J. R. Kraft, J. D. Altman, P. E. Jensen, and D. H. Raulet. 1998. Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J. Exp. Med. 188:1841.
70. Matsumoto, N., R. K. Ribaudo, J. P. Abastado, D. H. Margulies, and W. M. Yokoyama. 1998. The lectin-like NK cell receptor Ly49A recognizes a carbohydrate-independent epitope on its MHC class I ligand. Immunity 8:245.
71. d complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120. J. Mol. Biol. 283:179.
72. d)-mediated protection against Ly-49A+ NK cells after ammo acid substitutions in the antigen binding cleft. Eur. J. Immunol. 28:2872.
73. Holliger, P., T. Prospero, and G. Winter. 1993. "Diabodies": small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. USA 90:6444.
74. Poljak, R. J. 1994. Production and structure of diabodies. Structure 2:1121.
75. Kortt, A. A., M. Lah, G. W. Oddie, C. L. Gruen, J. E. Burns, L. A. Pearce, J. L. Atwell, A. J. McCoy, G. J. Howlett, D. W. Metzger, R. G. Webster, and P. J. Hudson. 1997. Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer. Protein Eng. 10:423.