MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6475-6479

  Andersson, Malena ^a   Freland, Sofia ^a   Johansson, Maria H ^a   Wallin, Robert ^a   Sandberg, Johan K ^a   Chambers, Benedict J ^a   Christensson, Birger ^b   Lendahl, Urban ^c   Lemieux, Suzanne ^d   Salcedo, Margarita ^a   Ljunggren, Hans Gustaf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD4 ANTIGEN; CD8 ANTIGEN; H2 ANTIGEN; LYMPHOCYTE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HAPLOTYPE; MALE; MOSAICISM; MOUSE; MOUSE MUTANT; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, LY; BETA 2-MICROGLOBULIN; CHIMERA; GENE EXPRESSION REGULATION; H-2 ANTIGENS; HAPLOTYPES; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LYMPHOCYTE COUNT; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; UP-REGULATION;

EID: 0032534589     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Raulet, D. H. 1994. MHC class I-deficient mice. Adv. Immunol. 55:381.
2. + T cells in mice with defects in the MHC class I antigen-presenting pathway. Immunol. Rev. 151:123.
3. Salcedo, M., and H. G. Ljunggren. 1996. Natural killer cells in MHC class I deficient mice. Chem. Immunol. 64:44.
4. + cytolytic T cells. Nature 344:742.
5. + T cells. Science 248:1227.
6. 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. J. Exp. Med. 179:661.
7. Bix, M., N. S. Liao, M. Zijlstra, J. Loring, R. Jaenisch, and D. Raulet. 1991. Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature 349:329.
8. Liao, N. S., M. Bix, M. Zijlstra, R. Jaenisch, and D. Raulet. 1991. MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science 253:199.
9. 2m§-bone marrow in chimeric mice. Proc. Natl. Acad. Sci. USA 88: 10332.
10. + IL-2-activated natural killer cells. Nature 358: 66.
11. Long, E. O., and N. Wagtmann. 1997. Natural killer cell receptors. Curr. Opin. Immunol. 9:344.
12. Lanier, L. L. 1997. Natural killer cells: from no receptors to too many. Immunity 6:171.
13. Yokoyama, W. M. 1997. What goes up must come down: the emerging spectrum of inhibitory receptors. J. Exp. Med. 186:1803.
14. Takei, F., J. Brennan, and D. L. Mager. 1997. The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155:67.
15. Sykes, M., M. W. Harty, F. M. Karlhofer, D. A. Pearson, G. Szot, and W. Yokoyama. 1993. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. J. Exp. Med. 178:223.
16. Karlhofer, F. M., R. Hunziker, A. Reichlin, D. H. Margulies, and W. M. Yokoyama. 1994. Host MHC class I molecules modulate in vivo expression of a NK cell receptor. J. Immunol. 153:2407.
17. Olsson, M. Y., K. Kärre, and C. L. Sentman. 1995. Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand. Proc. Natl. Acad. Sci. USA 92: 1649.
18. Held, W., J. R. Dorfman, M. F. Wu, and D. H. Raulet. 1996. Major histocompatibility complex class I-dependent skewing of the natural killer cell Ly49 receptor repertoire. Eur. J. Immunol. 26:2286.
19. Salcedo, M., A. D. Diehl, A. M. Olsson, J. Sundbäck, K. L. Van, K. Kärre, and H. G. Ljunggren. 1997. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J. Immunol. 158:3174.
20. Held, W., and D. H. Raulet. 1997. Ly49A transgenic mice provide evidence for a major histocompatibility complex-dependent education process in natural killer cell development. J. Exp. Med. 185:2079.
21. Fahlén, L., N. K. Khoo, M. R. Daws, and C. L. Sentman. 1997. Location-specific regulation of transgenic Ly49A receptors by major histocompatibility complex class I molecules. Eur. J. Immunol. 27:2057.
22. Gosselin, P., Y. Lusignan, J. Brennan, F. Takei, and S. Lemieux. 1997. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles. Int. Immunol. 9:533.
23. Salcedo, M., M. Andersson, S. Lemieux, L. Van Kaer, B. J. Chambers, and H. G. Ljunggren. 1998. Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I deficient mice. Eur. J. Immunol. 28:1315.
24. Johansson, M. H., C. Bieberich, G. Jay, K. Kärre, and P. Höglund. 1997. Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene. J. Exp. Med. 186:353.
25. Brennan, J., G. Mahon, D. L. Mager, W. A. Jefferies, and F. Takei. 1996. Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions. J. Exp. Med. 183:1553.
26. Yu, Y. Y., T. George, J. R. Dorfman, J. Roland, V. Kumar, and M. Bennett. 1996. The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. Immunity 4:67.
27. low NK cells. J. Immunol. 159:3189.
28. 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells. EMBO J. 2:1061.
29. Nilsson, E., and U. Lendahl. 1993. Transient expression of a human β-actin promoter/lacZ gene introduced into mouse embryos correlates with a low degree of methylation. Mol. Reprod. Dev. 34:149.
30. Lemieux, S., T. F. Ouellet, Y. Lusignan, L. Morelli, N. Labreche, P. Gosselin, and J. Lecomte. 1991. Identification of murine natural killer cell subsets with monoclonal antibodies derived from 129 anti-C57BL/6 immune spleen cells. Cell. Immunol. 134:191.
31. Höglund, P., J. Sundbäck, A. M. Olsson, M. Johansson, M. Salcedo, C. Öhlén, H. G. Ljunggren, C. L. Sentman, and K. Kärre. 1997. Host MHC class I gene control of NK-cell specificity in the mouse. Immunol. Rev. 155:11.
32. Sentman, C. L., M. Y. Olsson, and K. Kärre. 1995. Missing self recognition by natural killer cells in MHC class I transgenic mice: a 'receptor calibration' model for how effector cells adapt to self. Semin. Immunol. 7:109.
33. -/- mice. J. Immunol. 159:5219.
34. b heavy chains. Eur. J. Immunol. 28:370.
35. Kåse, A., M. H. Johansson, M. Y. Alheim, K. Kärre, and P. Höglund. 1998. External and internal calibration of MHC class I-specific receptor Ly49A on murine NK cells. J. Immunol. In press.