Flavins inhibit human cytomegalovirus UL80 protease via disulfide bond formation

Biochemistry

Volumn 35, Issue 18, 1996, Pages 5847-5855

  Baum, Ellen Z ^a   Ding, Wei Dong ^a   Siegel, Marshall M ^a   Hulmes, Jeff ^a,c   Bebernitz, Geraldine A ^a   Sridharan, Latha ^a   Tabei, Keiko ^a   Krishnamurthy, Girija ^a   Carofiglio, Tommaso ^b   Groves, John T ^b   Bloom, Jonathan D ^a   DiGrandi, Martin ^a   Bradley, Mary ^a   Ellestad, George ^a   Seddon, Andrew P ^a   Gluzman, Yakov ^a  

^a WYETH RESEARCH   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c Adirondack Biomedical Research Institute Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 7,8 DIMETHYL 6H PYRIMIDO[1,2 B] 1,2,4,5 TETRAZIN 6 ONE; CYSTEINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; PROTEINASE; PROTEINASE INHIBITOR; RIBOFLAVIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN CYTOMEGALOVIRUS; MASS SPECTROMETRY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEINASE INHIBITION;

BASE SEQUENCE; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; CYTOMEGALOVIRUS; DACARBAZINE; DISULFIDES; DNA PRIMERS; DNA, VIRAL; ENDOPEPTIDASES; FLAVINS; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; POINT MUTATION; PROTEASE INHIBITORS; VIRAL PROTEINS;

EID: 15844431140     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9529972     Document Type: Article

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