Potent selective thienoxazinone inhibitors of herpes proteases

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 13, 1997, Pages 1733-1738

  Jarvest, Richard L ^a   Connor, Susan C ^a   Gorniak, Joselina G ^a   Jennings, L John ^a   Serafinowska, Halina T ^a   West, Andrew ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOXAZINONE DERIVATIVE; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; THIENO[2,3 D]OXAZINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYTOMEGALOVIRUS; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HERPES SIMPLEX VIRUS; HERPES VIRUS; NONHUMAN; PROTEINASE INHIBITION; VIRUS INFECTION; VIRUS INHIBITION;

EID: 0030838803     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00300-4     Document Type: Article

References (19)

1. Liu, F.; Roizman B. J. Virol., 1991, 65, 5149.
2. Welch, A.R.; Woods, A.S.; McNally, L.M.; Cotter, R.J.; Gibson, W. Proc. Natl. Acad. Sci. USA, 1991, 88, 10792.
3. Gao, M.; Matusick-Kumar, L.; Hurlburt, W.; DiTusa S.F.; Newcomb, W.W.; Brown, J.C.; McCann, P.J. III; Deckman I.; Colonno, R.J. J. Virol., 1994, 68, 3702.
4. a. Tong, L.; Qian, C.; Massariol, M.-J.; Ronneau, P.R.; Cordingley, M.G.; Lagacé, L. Nature, 1996, 383, 272.
5. b. Qiu, X.; Culp, J.S.; DiLella, A.G.; Hellmig, B.; Hoog, S.S.; Janson, C.A.; Smith, W.W.; Abdel-Meguid, S.S. Nature, 1996, 383, 275.
6. c. Shieh H.-J.; Kurumbail, R.G.; Stevens, A.M.; Stegeman, R.A.; Sturman, E.J.; Pak, J.Y.; Wittwer, A.J.; Palmier, M.O.; Wiegand, R.C; Holwerda, B.C.; Stallings, W.C. Nature, 1996, 383, 279.
7. d. Chen P.; Tsuge, H,; Almassy, R.J.; Gribskov, C.L.; Katoh, S.; Vanderpool, D.L.; Margosiak, S.A.; Pinko, C.; Matthews, D.A.; Kan, C.-C. Cell, 1996, 86, 835.
8. Jarvest, R.L.; Parratt, M.J.; Debouck, C.M.: Gorniak J.G.; Jennings, L.J.; Serafinowska, H.T.; Strickler, J.E. Bioorg. Med. Chem. Lett., 1996, 6, 2463.
9. Pinto, I.P.; West, A.; Debouck, C.M.; DiLella, A.G.; Gorniak J.G.; O'Donnell, K.C; O'Shannessy, D.J.; Patel, A.; Jarvest, R.L. Bioorg. Med. Chem. Lett., 1996, 6, 2467.
10. Rossy, P; Vogel, F.G.M.; Hoffman, W.; Paust, J.; Nurrenbach, A. Tetrahedron Lett., 1981, 22, 3493. Rossy, P.A.; Vogel, F. Ger. Offen., DE 3,018,134 A1, 1981.
11. Rossy, P; Vogel, F.G.M.; Hoffman, W.; Paust, J.; Nurrenbach, A. Tetrahedron Lett., 1981, 22, 3493. Rossy, P.A.; Vogel, F. Ger. Offen., DE 3,018,134 A1, 1981.
12. Elliott, R.L.; O'Hanlon, P.J.; Rogers, N.H. Tetrahedron, 1987, 43, 3295.
13. Thiophene and its Derivatives, Ed. Gronowitz, S., John Wiley & Sons. a. Norris, R.K. Part 2, 1986, p 545; b. Gronowitz, S.; Hörnfeldt, A.-B. Part 4, 1991, p 1.
14. Thiophene and its Derivatives, Ed. Gronowitz, S., John Wiley & Sons. a. Norris, R.K. Part 2, 1986, p 545; b. Gronowitz, S.; Hörnfeldt, A.-B. Part 4, 1991, p 1.
15. Thiophene and its Derivatives, Ed. Gronowitz, S., John Wiley & Sons. a. Norris, R.K. Part 2, 1986, p 545; b. Gronowitz, S.; Hörnfeldt, A.-B. Part 4, 1991, p 1.
16. CH values above and in reference 8.
17. Hromatka, O.; Binder, D. Monatscheft, 1973, 104, 1343.
18. 5,6 and at a temperature of 27°C.
19. Morales-Rios, M.S.; Del Rio, R.E. and Joseph-Nathan, P. Magn. Reson. Chem., 1988, 26, 552.