Prediction of antisense oligonucleotide binding affinity to a structured RNA target

Biotechnology and Bioengineering

Volumn 65, Issue 1, 1999, Pages 1-9

  Walton, S Patrick ^a,b   Stephanopoulos, Gregory N ^b   Yarmush, Martin L ^a   Roth, Charles M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Affinity; Antisense; Hybridization; RNA folding

Indexed keywords

ALGORITHMS; BINDING ENERGY; BIOASSAY; CHEMICAL BONDS; COST EFFECTIVENESS; ENGINEERING RESEARCH; MATHEMATICAL MODELS; MEDICAL APPLICATIONS; RNA; THERMAL CYCLING;

ANTISENSE EFFICACY; BINDING AFFINITY; HYBRIDIZATION; OLIGONUCLEOTIDE; RNA FOLDING;

DNA SEQUENCES;

ANTISENSE OLIGONUCLEOTIDE; BETA GLOBIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; DNA RNA HYBRIDIZATION; NUCLEOTIDE SEQUENCE; RNA STRUCTURE; THERMODYNAMICS;

ANIMALS; BASE SEQUENCE; GLOBINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RABBITS; RNA, MESSENGER; THERMODYNAMICS; TUMOR NECROSIS FACTOR-ALPHA;

ORYCTOLAGUS CUNICULUS;

EID: 0033527352     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19991005)65:1<1::AID-BIT1>3.0.CO;2-F     Document Type: Article

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